Redox Bridling of GIRK Channel Activity
Function, 2023 pr otein-gated inw ardl y r ectifying potassium (GIRK, Kir3.x) hannels belong to the large family of inw ardl y r ectifying potasium (Kir) channels expressed throughout the body.
A. Boccaccio, Rocio K. Finol-Urdaneta
semanticscholar +5 more sources
The Relevance of GIRK Channels in Heart Function
Membranes, 2022 Among the large number of potassium-channel families implicated in the control of neuronal excitability, G-protein-gated inwardly rectifying potassium channels (GIRK/Kir3) have been found to be a main factor in heart control. These channels are activated
A. Campos-Ríos +2 more
semanticscholar +5 more sources
Domain-selective and sex-dependent regulation of learning and memory in mice by GIRK channel activity in CA1 pyramidal neurons of the dorsal hippocampus. [PDF]
Learn MemG protein-gated inwardly rectifying K+ (GIRK) channels mediate the postsynaptic inhibitory effect of many neurotransmitters in the hippocampus and are implicated in neurological disorders characterized by cognitive deficits.
Luo H +5 more
europepmc +2 more sources
Calcium Release from Stores Inhibits GIRK
Cell Reports, 2016 Synaptic transmission is mediated by ionotropic and metabotropic receptors that together regulate the rate and pattern of action potential firing. Metabotropic receptors can activate ion channels and modulate other receptors and channels.
Paul F. Kramer, John T. Williams
doaj +3 more sources
Loss of expression and function of Gβγ by GNB1 encephalopathy-associated L95P mutation of the Gβ1 subunit [PDF]
Frontiers in PharmacologyBackgroundG-proteins areindispensable regulators of cellular signaling, with G-protein-gated inwardly rectifying potassium channels (GIRK) as key effectors. GNB1 encephalopathy (GNB1E) is a congenital neurological syndrome resulting from mutations in the
Haritha P. Reddy +6 more
doaj +2 more sources
Alzheimer’s Research & Therapy, 2022 Alzheimer’s disease (AD) is characterized by a reorganization of brain activity determining network hyperexcitability and loss of synaptic plasticity.
Alejandro Martín-Belmonte +10 more
doaj +2 more sources
Reactivating the phototransduction cascade with a mutation agnostic gene therapy preserves vision in rod-cone dystrophies [PDF]
iScienceSummary: Rod-cone dystrophy (RCD) comprises genetic conditions where rod photoreceptor degeneration leads to cone loss, causing progressive vision loss.
Cardillia-Joe Simon +18 more
doaj +2 more sources
Encephalopathy-causing mutations in Gβ1 (GNB1) alter regulation of neuronal GIRK channels
iScience, 2021 Summary: Mutations in the GNB1 gene, encoding the Gβ1 subunit of heterotrimeric G proteins, cause GNB1 Encephalopathy. Patients experience seizures, pointing to abnormal activity of ion channels or neurotransmitter receptors.
Haritha P. Reddy +11 more
doaj +2 more sources
Activin A Reduces GIRK Current to Excite Dentate Gyrus Granule Cells
Frontiers in Cellular Neuroscience, 2022 Activin A, a member of the TGF-β family, is recognized as a multifunctional protein in the adult brain with a particular impact on neuronal circuits associated with cognitive and affective functions.
Fang Zheng +3 more
doaj +2 more sources
Distinct regulation of dopamine D2S and D2L autoreceptor signaling by calcium [PDF]
eLife, 2015 D2 autoreceptors regulate dopamine release throughout the brain. Two isoforms of the D2 receptor, D2S and D2L, are expressed in midbrain dopamine neurons. Differential roles of these isoforms as autoreceptors are poorly understood.
Stephanie C Gantz +6 more
doaj +5 more sources