Results 61 to 70 of about 10,013 (222)
International Journal of Molecular Sciences, 2021 G protein-gated inwardly rectifying K+ (GIRK) channels are the main targets controlling excitability and synaptic plasticity on hippocampal neurons.
Rocío Alfaro-Ruiz +6 more
semanticscholar +1 more source
Cholesterol Regulation of Atrial GIRk Channels [PDF]
Biophysical Journal, 2014 In recent years, cholesterol emerged as a major regulator of ion channel function. The most common effect of cholesterol on ion channels is a decrease in channel activity. Here we focus on G-protein gated inwardly rectifying potassium (GIRK or Kir3) channels that play an important role in regulating membrane excitability in cardiac, neuronal and ...
Bukiya, Anna N. +7 more
openaire +1 more source
Structural insights into GIRK2 channel modulation by cholesterol and PIP2
Cell Reports, 2021 Summary: G-protein-gated inwardly rectifying potassium (GIRK) channels are important for determining neuronal excitability. In addition to G proteins, GIRK channels are potentiated by membrane cholesterol, which is elevated in the brains of people with ...
Yamuna Kalyani Mathiharan +5 more
doaj +1 more source
p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate [PDF]
, 2008 The pan neurotrophin receptor p75(NTR) signals programmed cell death both during nervous system development and after neural trauma and disease in the adult. However, the molecular pathways by which death is mediated remain poorly understood.
Bartlett, P. F. +7 more
core +1 more source
Modeling GIRK channel conductance [PDF]
Journal of General Physiology, 2019 JGP study uses MD simulations to investigate the gating and conductance of the inwardly rectifying potassium channel GIRK2.
openaire +2 more sources
Neurochemical characterisation of lamina II inhibitory interneurons that express GFP in the PrP-GFP mouse [PDF]
, 2013 Background Inhibitory interneurons in the superficial dorsal horn play important roles in modulating sensory transmission, and these roles are thought to be performed by distinct functional populations. We have identified 4 non-overlapping classes among
Garzillo, F. +4 more
core +2 more sources
Journal of Lipid Research, 2019 Cholesterol, a critical component of the cellular plasma membrane, is essential for normal neuronal function. Cholesterol content is highest in the brain, where most cholesterol is synthesized de novo; HMG-CoA reductase controls the synthesis rate ...
Anna N. Bukiya +2 more
doaj +1 more source
TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel [PDF]
, 2014 Transient receptor potential (TRP) channels, a superfamily of ion channels, can be divided into 7 subfamilies, including TRPV, TRPC, TRPP, and 4 others. Functional TRP channels are tetrameric complexes consisting of 4 pore-forming subunits.
Birnbaumer, Lutz +5 more
core +1 more source
International Journal of Molecular Sciences, 2022 G-protein-gated inwardly rectifying potassium (GIRK) channels are critical determinants of neuronal excitability. They have been proposed as potential targets to restore excitatory/inhibitory balance in acute amyloidosis models, where hyperexcitability ...
Sara Temprano‐Carazo +4 more
semanticscholar +1 more source
Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances [PDF]
, 2006 The hypothalamic melanocortin system is crucial for the control of appetite and body weight. Two of the five melanocortin receptors, MC3R and MC4R are involved in hypothalamic control of energy homeostasis, with the MC4R having the major influence. It is
Acuna-Goycolea +41 more
core +4 more sources