Results 101 to 110 of about 3,475 (207)

Comparative bio-accessibility, bioavailability and bioequivalence of quercetin, apigenin, glucoraphanin and carotenoids from freeze-dried vegetables incorporated into a baked snack versus minimally processed vegetables:Evidence from in vitro models and a human bioavailability study [PDF]

, 2018
The aim was to incorporate vegetables containing the phytochemicals quercetin, apigenin, glucoraphanin and carotenoids into a processed potato-based snack and assess their bioaccessibility and bioavailability.
Hollands, Wendy J., Hart, Dave J., Spurr, Mike, Perez-Moral, Natalia, van der Velpen, Vera, Saha, Shikha, Bows, John, Winterbone, Mark S., Philo, Mark, Curtis, Peter J., Kroon, Paul A.   +10 more
core   +1 more source

Computational Insights Into Plant‐Derived Compounds Modulating the Microbiota–Gut–Brain Axis in Neuroinflammatory Diseases

Advanced Gut &Microbiome Research, Volume 2026, Issue 1, 2026.
Neuroinflammatory disorders, such as Alzheimer’s disease (AD) and multiple sclerosis (MS), are increasingly recognized as systemic inflammatory syndromes rather than isolated brain pathologies. A central regulator of this systemic response is the microbiota–gut–brain axis (MGBA), where dysbiosis‐induced disruption accelerates neuroinflammation and ...
Amin Purhematy, Fariba Sharififar, Emmanuel Mshelia Halilu, Jiong Yu   +3 more
wiley   +1 more source

Cooked broccoli alters cecal microbiota and impacts microbial metabolism of glucoraphanin in lean and obese mice

, 2023
This study evaluated how 7-day cooked broccoli consumption impact cecal microbiota composition and microbial metabolism of ...
University of Illinois (17854838)
core  

Plant-derived bioactives, the gut–brain axis, and neurodegenerative diseases: mechanistic roles of diet–microbiota interactions

Frontiers in Neuroscience
Diet is increasingly recognized as a potential upstream modulator of the gut-brain axis (GBA) through its effects on the microbiome, microbial metabolites, and host immune and endocrine responses.
Ashley Reynolds, Ethan Glenn, Brigitte Lavoie, Suzanne L. Ishaq, Yanyan Li   +4 more
doaj   +1 more source

Nrf2 Activation in Inflammatory Diseases: A Review of Natural and Synthetic Modulators

Oxidative Medicine and Cellular Longevity, Volume 2026, Issue 1, 2026.
The nuclear factor erythroid 2–related factor 2 (Nrf2) pathway is a central regulator of the cellular antioxidant response, playing a key role in modulating inflammation and defending against oxidative stress‐induced damage. A range of natural and synthetic compounds, including dimethyl fumarate, bardoxolone, oltipraz, RTA‐408, ursodiol, curcumin ...
Vitória B. Costa, Iolanda A. F. de Matos, Isabela R. G. Nogueira, Mariely A. de Godoi, Fábio R. M. Leite, Morgana R. Guimarães-Stabili, Dario Ramirez   +6 more
wiley   +1 more source

The Antimicrobial Effects of Myrosinase Hydrolysis Products Derived from Glucosinolates Isolated from Lepidium draba

Plants
Lepidium draba (hoary cress) is a perennial plant belonging to the Brassicaceae family that produces two dominant glucosinolates (GLSs): glucoraphanin (GRN) and sinalbin (SBN).
Zoltán Polozsányi, Helena Galádová, Michal Kaliňák, Martin Jopčík, Barbora Kaliňáková, Albert Breier, Martin Šimkovič   +6 more
doaj   +1 more source

Dietary intake of glucoraphanin during pregnancy and lactation prevents the behavioral abnormalities in the offspring after maternal immune activation

Neuropsychopharmacology Reports, 2020
Aim Epidemiological data suggest that maternal immune activation (MIA) plays a role in the etiology of neuropsychiatric disorders including autism spectrum disorder (ASD) and schizophrenia. However, there is no prophylactic nutrition that can prevent the
Yuko Fujita, Atsuhiro Fujita, Tamaki Ishima, Ayumi Hirai, Shigenori Suzuki, Hiroyuki Suganuma, Kenji Hashimoto   +6 more
doaj   +1 more source

Clinical and molecular evidence of the consumption of broccoli, glucoraphanin and sulforaphane in humans.

Nutricion hospitalaria, 2015
Introduction: Sulforaphane (SFN) is an isothiocyanate derived from glucoraphanin (GRA), which is found in great amounts especially in broccoli. Its consumption has been reported to be associated with a lower risk of myocardial infarction and cancer development.
Conzatti, Adriana, Fróes, Fernanda Carolina Telles da Silva, Perry, Ingrid Dalira Schweigert, Souza, Carolina Guerini de   +3 more
openaire   +3 more sources

Glucoraphanin is hydrolyzed by lactobacilli in vitro and rat cecal microbiota in vitro and in situ.

The FASEB Journal, 2009
Glucoraphanin (GP) is a major glucosinolate in broccoli. To become active as an anticarcinogen, GP needs hydrolysis to the isothiocyanate sulforaphane (SF), either by the endogenous plant enzyme myrosinase or possibly by microbiota in the GI tract. Five Lactobacillus
Ren‐Hau Lai, Michael J Miller, Elizabeth H Jeffery   +2 more
openaire   +1 more source

Long-Term Intake of Glucoraphanin-Enriched Kale Suppresses Skin Aging via Activating Nrf2 and the TβRII/Smad Pathway in SAMP1 Mice

, 2019
Sulforaphane, a potent antioxidant compound, is unstable at ambient temperature, whereas its precursor glucoraphanin is stable and metabolized to sulforaphane. Thus, we hypothesized that glucoraphanin-rich diet could effectively induce antioxidant enzyme
Saki Ichikawa, Soichiro Nakamura (1901200), Saki Ichikawa (1746319), Yuki Uchibori (7296035), Shigeru Katayama (1901203), Yuki Uchibori, Shigeru Katayama, Supatta Chawalitpong (4692445), Supatta Chawalitpong, Soichiro Nakamura   +9 more
core   +1 more source