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Glucoraphanin and sulforaphane mitigate TNFα-induced Caco-2 monolayers permeabilization and inflammation

Redox Biology
Intestinal permeabilization is central to the pathophysiology of chronic gut inflammation. This study investigated the efficacy of glucoraphanin (GR), prevalent in cruciferous vegetables, particularly broccoli, and its derivative sulforaphane (SF), in ...
Wei Zhu, E. Cremonini, Angela Mastaloudis, Patricia I. Oteiza   +3 more
semanticscholar   +6 more sources

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The effect of processing and cooking on glucoraphanin and sulforaphane in brassica vegetables.

Food Chemistry, 2021
Brassica vegetables are widely consumed mostly after processing and cooking. These processing and cooking methods not only can affect the taste, texture, flavor and nutrients of these vegetables, but also influence the levels of some important bioactive compounds, such as glucosinolates (GLSs).
Jing Sun, Yunfan Wang, Xinyi Pang, Shuhua Tian, Qiaobin Hu, Xiangfei Li, Jie Liu, Jing Wang, Yingjian Lu   +8 more
semanticscholar   +3 more sources

Calcium affects glucoraphanin metabolism in broccoli sprouts under ZnSO4 stress

Food Chemistry, 2021
CaCl2, Ca2+ chelator (EGTA) and Ca2+ channel blocker (verapamil) were used to investigate mechanism of glucoraphanin metabolism in broccoli sprouts under ZnSO4 stress. CaCl2 treatment promoted sprout growth, reduced MDA (malonaldehyde) content and electrolyte leakage in sprouts under ZnSO4 stress.
Yinglian Zhu, Fengwu Wang
exaly   +3 more sources

Bifidobacterium longum CCFM1206 Promotes the Biotransformation of Glucoraphanin to Sulforaphane That Contributes to Amelioration of Dextran-Sulfate-Sodium-Induced Colitis in Mice.

Journal of Agricultural and Food Chemistry, 2023
Glucoraphanin, rich in broccoli seed extract (BSE), is generally inert but can be biotransformed into active sulforaphane by gut bacteria. This study aimed to screen probiotics with glucoraphanin-metabolizing ability and explore the effect of a ...
Jiaying Wu, Shumao Cui, Xin Tang, Qiuxiang Zhang, Yan Jin, Jianxin Zhao, Bingyong Mao, Hao Zhang   +7 more
semanticscholar   +1 more source

CRISPR/Cas9-mediated BoaAOP2s editing alters aliphatic glucosinolate side-chain metabolic flux and increases the glucoraphanin content in Chinese kale.

Food Research International, 2023
Glucoraphanin (GRA) is an aliphatic glucosinolate (GSL), and its hydrolysis product has powerful anticancer activity. ALKENYL HYDROXALKYL PRODUCING 2 (AOP2) gene, encodes a 2-oxoglutarate-dependent dioxygenase, which can catalyze GRA to form gluconapin ...
Hao Zheng, Wenli Huang, Xiangxiang Li, Huanhuan Huang, Q. Yuan, Ruobin Liu, Hongmei Di, Sha Liang, Mengyu Wang, Mengyao Li, Zhi Huang, Yingzi Tang, Ya-Di Zheng, Huiying Miao, Jie Ma, Huanxiu Li, Qiaomei Wang, B. Sun, Fen Zhang   +18 more
semanticscholar   +1 more source

A total synthesis of ( R , S ) S -glucoraphanin

Tetrahedron, 2013
Abstract A total synthesis of (R,S)S-glucoraphanin (GRP) has been completed by a novel, simple and convenient method in high overall yield (17% over seven steps). The study describes a method for the synthesis of natural and unnatural (methylsulfinyl)alkyl glucosinolates (GLs) and also opens useful pathways to synthesize GRP as well as other sulfinyl
Quan V Võ, Simone Rochfort
exaly   +2 more sources

Purification of a Sinapine-Glucoraphanin Salt from Broccoli Seeds

American Journal of Plant Sciences, 2010
A sinapine (sinapoylcholine)-glucoraphanin salt has been isolated from broccoli seeds and characterized by NMR and mass spectrometry. This salt extraction method can be used to purify glucoraphanin free from contamination by glucoiberin.
Mark A Berhow, Steven F Vaughn
exaly   +3 more sources

The Metabolic Fate of Purified Glucoraphanin in F344 Rats

Journal of Agricultural and Food Chemistry, 2007
Dietary broccoli is commonly eaten cooked, exposing individuals to intact glucoraphanin rather than to its hydrolysis product, the anticarcinogenic isothiocyanate sulforaphane, since cooking destroys the hydrolyzing enzyme myrosinase. There is little information on the absorption and metabolism of glucoraphanin, due partly to the lack of purified ...
Radha M, Bheemreddy, Elizabeth H, Jeffery   +1 more
openaire   +2 more sources

Evaluation of the safety and bioactivity of purified and semi-purified glucoraphanin

Food and Chemical Toxicology, 2008
The anti-carcinogenic effects of broccoli have been attributed to sulforaphane, the hydrolysis product of glucoraphanin (GRP). Here we determined if purified GRP, in the absence of the plant-derived hydrolyzing enzyme myrosinase, could affect pulmonary and hepatic ethoxyresorufin O-deethylase (EROD) and/or NAD(P)H-quinone oxidoreductase 1 (NQO1 ...
R-H, Lai, A-S, Keck, M A, Wallig, L G, West, E H, Jeffery   +4 more
openaire   +2 more sources

The determination of glucoraphanin in broccoli seeds and florets by solid phase extraction and micellar electrokinetic capillary chromatography

Food Chemistry, 2006
A robust method for the determination of glucoraphanin in broccoli (brassica oleracea ssp. italica ‘Marathon’) seeds and florets has been developed using solid phase extraction (SPE) and micellar electrokinetic capillary chromatography (MECC) as the ...
Aaron Elkins, Rod Jones, V Craige Trenerry   +2 more
exaly   +2 more sources