Results 21 to 30 of about 4,725 (241)

Broccoli or Sulforaphane: Is It the Source or Dose That Matters? [PDF]

Molecules, 2019
There is robust epidemiological evidence for the beneficial effects of broccoli consumption on health, many of them clearly mediated by the isothiocyanate sulforaphane.
Yoko Yagishita, Jed W. Fahey, Albena T. Dinkova-Kostova, Thomas W. Kensler   +3 more
doaj   +4 more sources

Cooked Broccoli Alters Cecal Microbiota and Impacts Microbial Metabolism of Glucoraphanin in Lean and Obese Mice. [PDF]

Mol Nutr Food Res
Scope Brassica vegetables contain unique compounds known as glucosinolates (GSLs), which, when hydrolyzed by plant or microbial myrosinase, form bioactive isothiocyanates (ITCs) that offer health benefits to the host.
Zhao A, Li J, Peterson M, Black M, Gaulke CA, Jeffery EH, Miller MJ.   +6 more
europepmc   +2 more sources

Correction: Micheli et al. Beneficial Effect of H₂S-Releasing Molecules in an In Vitro Model of Sarcopenia: Relevance of Glucoraphanin. <i>Int. J. Mol. Sci.</i> 2022, <i>23</i>, 5955. [PDF]

Int J Mol Sci
In the original publication [...].
Micheli L, Mitidieri E, Turnaturi C, Vanacore D, Ciampi C, Lucarini E, Cirino G, Ghelardini C, Sorrentino R, Di Cesare Mannelli L, d'Emmanuele di Villa Bianca R.   +10 more
europepmc   +2 more sources

Bioavailability of Glucoraphanin and Sulforaphane From High-Glucoraphanin Broccoli [PDF]

Molecular Nutrition & Food Research, 2018
Scope: Broccoli accumulates 4-methylsulphinylbutyl glucosinolate (glucoraphanin) which is hydrolyzed to the isothiocyanate sulforaphane. Through the introgression of novel alleles of the Myb28 transcription factor from Brassica villosa, broccoli ...
Al Janobi, Aune, Clarke, Clarke, Cotton, Covault, Fuentes, Gasper, Gigolashvili, Juge, Kassahun, Liu, Liu, Luang-In, Mithen, Saha, Sonderby, Thomson, Traka, Tse, Vermeulen, Wu, Zhang   +22 more
core   +6 more sources

Sulforaphane in cancer precision medicine: from biosynthetic origins to multiscale mechanisms and clinical translation [PDF]

Frontiers in Immunology
Sulforaphane (SFN), an isothiocyanate derived from glucoraphanin in cruciferous vegetables, has evolved from a dietary antioxidant to a sophisticated multi-target agent in oncology.
Zhipeng Zhao, Zhipeng Zhao, Zhipeng Zhao, Qianyue Chen, Xinyu Qiao, Xinyu Qiao, Xinyu Qiao, Jianjiang Wang, Zaid Tala Abdulqader Ali, Jun Li, Ling Yin, Ling Yin   +11 more
doaj   +2 more sources

Exogenous Melatonin Promotes Glucoraphanin Biosynthesis by Mediating Glutathione in Hairy Roots of Broccoli (Brassica oleracea L. var. italica Planch)

Plants, 2023
To investigate the mechanism of melatonin (MT)-mediated glutathione (GSH) in promoting glucoraphanin (GRA) and sulforaphane (SF) synthesis, the gene expression pattern and protein content of hairy broccoli roots under MT treatment were analyzed by a ...
Jinyu Bao, Jie Yang, Xu Lu, Lei Ma, Xiaotong Shi, Shimin Lan, Yi Zhao, Jie Cao, Shaoying Ma, Sheng Li   +9 more
doaj   +2 more sources

Optimization of Heterologous Glucoraphanin Production In Planta. [PDF]

ACS Synthetic Biology, 2022
Glucoraphanin is a plant specialized metabolite found in cruciferous vegetables that has long been a target for production in a heterologous host because it can subsequently be hydrolyzed to form the chemopreventive compound sulforaphane before and ...
Collin R Barnum, Benjamin J Endelman, Izaiah J. Ornelas, Roxanna M Pignolet, P. Shih   +4 more
semanticscholar   +4 more sources

Influence of sequential exogenous pretreatment and contact ultrasound-assisted air drying on the metabolic pathway of glucoraphanin in broccoli florets

Ultrasonics Sonochemistry, 2022
In this investigation, the combinations of exogenous pretreatment (melatonin or vitamin C) and contact ultrasound-assisted air drying were utilized to dry broccoli florets. To understand the influences of the studied dehydration methods on the conversion
Beini Liu, Yang Tao, Sivakumar Manickam, Dandan Li, Yongbin Han, Ying Yu, Dongfeng Liu   +6 more
doaj   +2 more sources

Bioactivated Glucoraphanin Improves Cell Survival, Upregulating Phospho-AKT, and Modulates Genes Involved in DNA Repair in an In Vitro Alzheimer's Disease Model: A Network-Transcriptomic Analysis. [PDF]

Nutrients
Background/Objectives: Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases, for which a definitive cure is still missing. Recently, natural compounds have been investigated for their possible neuroprotective role, including the ...
Minuti A, Mazzon E, Iori R, Chiricosta L, Artimagnella O.   +4 more
europepmc   +2 more sources

Hydrogel Beads Loaded with Glucosinolate-Rich Brassicaceae Extract as a Controlled-Release Alternative to Biofumigation [PDF]

Molecules
Biofumigation was originally proposed as an alternative to toxic fumigants for the treatment of agricultural soils, owing to the biocidal effect of isothiocyanates (ITCs) released by some plant species like Brassicaceae.
Michele Baglioni, Ilaria Clemente, Raffaello Nardin, Flavia Bisozzi, Sara Costantini, Giacomo Fattori, Gabriella Tamasi, Claudio Rossi   +7 more
doaj   +2 more sources