Elucidation of Sulforaphane-Mediated Effects on the Cellular Human Metabolome Using Metabolic Profiling. [PDF]
Mol Nutr Food ResSulforaphane (SFN) is an isothiocyanate derived from broccoli and is related to various health‐promoting effects. By using metabolic profiling on the hepatoblastoma cell line HepG2 several effects on pathways such as TCA cycle, urea cycle and redox metabolism through SFN were identified.
Bieß N +3 more
europepmc +2 more sources
Dietary Broccoli Alters Rat Cecal Microbiota to Improve Glucoraphanin Hydrolysis to Bioactive Isothiocyanates [PDF]
Nutrients, 2017 Broccoli consumption brings many health benefits, including reducing the risk of cancer and inflammatory diseases. The objectives of this study were to identify global alterations in the cecal microbiota composition using 16S rRNA sequencing analysis and glucoraphanin (GRP) hydrolysis to isothiocyanates ex vivo by the cecal microbiota, following ...
Xiaoji Liu +5 more
openalex +5 more sources
Analysis of Different Parts of Broccoli (<i>Brassica oleracea</i> var. <i>italica</i>) Leaves and Retention of Functional Compounds Under Different Cooking Methods. [PDF]
Food Sci NutrThis research examines the potential of broccoli leaves, which are often overlooked as a vegetable by‐product, as a functional food ingredient. The study involved phytochemical profiling and an analysis of antioxidant activity across various leaf parts and cooking methods.
Kim MG, Park JH, Joo N.
europepmc +2 more sources
Toxicological assessment of truebroc® glucoraphanin-rich broccoli seed extract [PDF]
Toxicology Research and Application, 2022 TrueBroc® Glucoraphanin-Rich Broccoli Seed Extract (TrueBroc®), is a hot water extract of Brassica oleracea var. Italica Plenck (Brassicaceae) seeds. The broccoli seeds are non-genetically modified and are tested and selected for their specific glucosinolate content.
Claire Kruger +2 more
openalex +3 more sources
Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice [PDF]
Diabetes, 2017 N. Nagata +13 more
semanticscholar +2 more sources
Effects of nanocarbon solution treatment on the nutrients and glucosinolate metabolism in broccoli
Food Chemistry: X, 2022 The effects of a nanocarbon solution on the nutrients, glucosinolate metabolism and glucoraphanin pathway in broccoli were investigated. Significant positive linear relationships were observed between the nanocarbon solution and total protein yield ...
Zhansheng Li +5 more
doaj +1 more source
Production of the Cancer-Preventive Glucoraphanin in Tobacco [PDF]
Molecular Plant, 2010 Epidemiological studies have demonstrated reduced risk of developing cancer upon consumption of diets rich in cruciferous vegetables. This chemoprevention has been largely attributed to the presence of the natural products glucosinolates, particularly the methionine-derived glucoraphanin from broccoli.
Mikkelsen, Michael Dalgaard +2 more
openaire +3 more sources
Applied Sciences, 2023 Broccoli (Brassica oleracea L. var. italica) is a globally popular vegetable because of its nutrient richness, especially its glucosinolates (GSLs). The content of GSLs in different organs of broccoli varies greatly.
Xiuling Tian +7 more
doaj +1 more source
Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder [PDF]
, 2020 Autism Spectrum Disorder (ASD) is one of the most common neurodevelopmental disorders with no drugs treating the core symptoms and no validated biomarkers for clinical use.
Connors, Susan L. +7 more
core +3 more sources
Glucosinolate hydrolysis and bioavailability of resulting isothiocyanates: Focus on glucoraphanin
Journal of Functional Foods, 2013 There is a growing interest in the health benefits of broccoli. Sulforaphane, the major bioactive component in broccoli, is an unstable isothiocyanate stored in the plant as glucoraphanin. Myrosinase enzymes release sulforaphane when the plant is crushed. Extraction during supplement formulation or heat processing can destroy myrosinase.
Donato Angelino, Elizabeth H. Jeffery
openalex +4 more sources