Results 71 to 80 of about 38,797 (256)

Neferine Promotes GLUT4 Expression and Fusion With the Plasma Membrane to Induce Glucose Uptake in L6 Cells

Frontiers in Pharmacology, 2019
Glucose transporter 4 (GLUT4) is involved in regulating glucose uptake in striated muscle, liver, and adipose tissue. Neferine is a dibenzyl isoquinoline alkaloid derived from dietary lotus seeds and has multiple pharmacological effects.
Ping Zhao, Ping Zhao, Ping Zhao, Di Tian, Guanjun Song, Qian Ming, Jia Liu, Jinhua Shen, Jinhua Shen, Qing-Hua Liu, Qing-Hua Liu, Xinzhou Yang, Xinzhou Yang   +12 more
doaj   +1 more source

Huntingtin-associated protein 1 plays an essential role in the pathogenesis of type 2 diabetes by regulating the translocation of GLUT4 in mouse adipocytes

BMJ Open Diabetes Research & Care, 2020
Objective Glucose disposal by insulin-responsive tissues maintains the body glucose homeostasis and insulin resistance leads to a risk of developing type 2 diabetes (T2DM).
Yan-Ju Gong, Ying Feng, Yuan-Yuan Cao, Jia Zhao, Ya-Yun Zheng, Jia-Rui Wu, Gui-Zhi Yang   +6 more
doaj   +1 more source

Exercise and adipose tissue GLUT4 [PDF]

, 2017
© 2017 Dr. Marcelo Alejandro Flores OpazoGLUT4 is the major insulin-sensitive glucose transporter expressed predominantly in skeletal & cardiac muscles, and adipose tissue (AT) and mediates insulin-stimulated glucose transport into these tissues.
Flores Opazo, Marcelo Alejandro
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Sleep deprivation aggravates hepatocytes steatosis and insulin resistance by regulating exosomal microRNAs

Interdisciplinary Medicine, EarlyView.
Sleep deprivation accelerates the progression of MASLD and IR by up‐regulating the expression of miR‐3572‐5p and down‐regulating the expression of miR‐183‐5p in circulating exosomes, thereby inhibiting fatty acid β‐oxidation and disrupting insulin signaling pathways. Abstract Sleep deprivation (SD) threatens human health and increases the prevalence of 
Xinxin Xu, Lulu Li, Ying Cao, Ying Wang, Chao Yang, Alexander Nikolaevich Orekhov, Yuanfeng Lu, Houbin Chu, Chuanrong Zhao, Guixue Wang, Guohua Song   +10 more
wiley   +1 more source

Wedelolactone from Eclipta prostrata (L) L. suppresses inflammation and improves insulin resistance

Asian Pacific Journal of Tropical Biomedicine
Objective: To evaluate the effects of wedelolactone, a major flavonoid from Vietnamese Eclipta prostrata (L) L., on inflammation and insulin resistance. Methods: Wedelolactone was extracted from the leaves of Vietnamese Eclipta prostrata (L.) L.
Trinh Tat Cuong, Duong Duc Thien, Hoang Hai Yen, Nguyen Anh Duc, Trinh Quang Nam, Do Viet Khanh   +5 more
doaj   +1 more source

Abnormal subcellular distribution of GLUT4 protein in obese and insulin-treated diabetic female dogs

Brazilian Journal of Medical and Biological Research, 2004
The GLUT4 transporter plays a key role in insulin-induced glucose uptake, which is impaired in insulin resistance. The objective of the present study was to investigate the tissue content and the subcellular distribution of GLUT4 protein in 4- to 12-year-
A.M. Vargas, R.P.A. Barros, R.A. Zampieri, M.M. Okamoto, P. de Carvalho Papa, U.F. Machado   +5 more
doaj   +1 more source

The CHC22 clathrin-GLUT4 transport pathway contributes to skeletal muscle regeneration. [PDF]

PLoS ONE, 2013
Mobilization of the GLUT4 glucose transporter from intracellular storage vesicles provides a mechanism for insulin-responsive glucose import into skeletal muscle.
Sachiko Hoshino, Kazuho Sakamoto, Stéphane Vassilopoulos, Stéphane M Camus, Christine A Griffin, Christopher Esk, Jorge A Torres, Norio Ohkoshi, Akiko Ishii, Akira Tamaoka, Birgit H Funke, Raju Kucherlapati, Marta Margeta, Thomas A Rando, Frances M Brodsky   +14 more
doaj   +1 more source

The effects of royal jelly on human health: A narrative review of clinical studies

JSFA reports, EarlyView.
Abstract Royal jelly (RJ) is a natural bioactive substance with documented effects on human health. This narrative review synthesizes evidence from clinical and clinically relevant experimental studies evaluating the therapeutic potential of RJ.
Georgios Goras, Andreas Thrasyvoulou, Evanthia Tsilimpokou   +2 more
wiley   +1 more source

Observing GLUT4 Translocation in Live L6 Cells Using Quantum Dots

Sensors, 2011
The glucose transporter 4 (GLUT4) plays a key role in maintaining whole body glucose homeostasis. Tracking GLUT4 in space and time can provide new insights for understanding the mechanisms of insulin-regulated GLUT4 translocation.
Feng Qu, Zubin Chen, Zhengxing Wu, Lingfeng Meng, Anlian Qu, Xiaoxuan Wang   +5 more
doaj   +1 more source

Investigating GLUT4 trafficking in muscle [PDF]

, 2010
GLUT4 trafficking in muscle cells has been studied to determine how distinct signalling pathways induce GLUT4 translocation. Two different cell models were adopted for these investigations; cardiomyocytes isolated from a transgenic mouse line expressing ...
Fazakerley, Daniel, Fazakerley, Daniel John   +1 more
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