Results 81 to 90 of about 38,797 (256)
Elongated Shape of GLUT4 Clusters.
, 2013 (a) FPALM reconstruction of GLUT4-EOS positions detected during 600 frames. Clustered positions were associated with GLUT4 molecules trapped inside the clusters. Bar, 1 µm. (b) An example of GLUT4 trajectory within the cluster; sequential positions where
Vladimir A. Lizunov (387113) +4 more
core +1 more source
Journal of the Science of Food and Agriculture, EarlyView.Abstract Energy bars are widely consumed functional foods among athletes and physically active consumers who require convenient sources of sustained energy. Their carbohydrate composition, particularly the type and ratio of digestible sugars such as glucose, fructose and sucrose, strongly influences glycaemic index (GI), postprandial blood glucose ...
Raju Sasikumar +8 more
wiley +1 more source
(+)-Rutamarin enhances both GLUT4 translocation and expression.
, 2012 (a) Chemical structure of (+)-Rutamarin. (b) Insulin (170 nM) activates GLUT4 translocation within 5 minutes in CHO-K1/GLUT4 cells that are pre-treated with Rut (20 µM) for 8 hours followed by insulin (170 nM) stimulation for 5 minutes, with (c) EC50 ...
Hong Shen (166278) +11 more
core +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley +1 more source
Flow cytometry protocol for GLUT4-myc detection on cell surfaces
Insulin and muscle contraction trigger GLUT4 translocation to the plasma membrane, which increases glucose uptake by muscle cells. Insulin resistance and type 2 diabetes are the result of impaired GLUT4 translocation.
Pavarotti, Martin Alejandro +2 more
core +1 more source
SNARE proteins underpin insulin-regulated GLUT4 traffic.
, 2011 Delivery of the glucose transporter, GLUT4 from an intracellular location to the cell surface in response to insulin represents a specialised form of membrane traffic, known to be impaired in the disease states of insulin-resistance and Type-2 diabetes ...
Nia J. Bryant +3 more
core +1 more source
Lipids, EarlyView.The experimental design and the exometabolomic findings obtained by 1H‐NMR analysis of conditioned media from subcutaneous (SAT) and epididymal adipose tissue (EAT) explants of control and obese mice supplemented with chia oil (1.5% (w/w)). Following 8 weeks of control or high‐fat diet and 5 weeks of chia oil supplementation, SAT and EAT explants were ...
Gilson Costa dos Santos Jr +5 more
wiley +1 more source
(+)-Rutamarin as a dual inducer of both GLUT4 translocation and expression efficiently ameliorates glucose homeostasis in insulin-resistant mice. [PDF]
PLoS ONE, 2012 Glucose transporter 4 (GLUT4) is a principal glucose transporter in response to insulin, and impaired translocation or decreased expression of GLUT4 is believed to be one of the major pathological features of type 2 diabetes mellitus (T2DM).
Yu Zhang +11 more
doaj +1 more source
TIRFing out Studies on Glut4 Trafficking [PDF]
Developmental Cell, 2007 Docking and fusion of Glut4 vesicles with the plasma membrane are essential but poorly understood steps during insulin-stimulated glucose transport. Recent studies utilizing TIRF microscopy shed light on these processes and map the sites of possible intervention by insulin from just underneath the plasma membrane.
Chen, Xiao-Wei, Saltiel, Alan R.
openaire +2 more sources
The Journal of Pathology, EarlyView.Abstract Acquired lipodystrophy in the dermal white adipose tissue (DWAT) is an early phenotype of skin fibrosis, followed by the accumulation of extracellular matrix (ECM). Lipodystrophy syndromes are estimated to affect 1 in 20,000 people and are associated with metabolic comorbidities.
Suneeti R Madhavan +10 more
wiley +1 more source