Results 111 to 120 of about 153,025 (224)
, 2018 1 Broadside. 48"W x 36"HNeurodegenerative diseases are characterized by neuronal impairment or death Glutamate excitotoxicity is a neuronal death pathway involved in many neurodegenerative diseases1 Glutamate excitotoxicity occurs when extracellular
Keramidas, Christina
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Nature Communications, 2016 Huntington disease (HD) has been linked via biochemical uptake assays to impaired glutamate clearance and resultant excitotoxicity. Here, utilizing a fluorescent reporter, the authors measure real-time glutamate dynamics in mouse model HD brain slices ...
Matthew P. Parsons +5 more
doaj +1 more source
Glia, Volume 74, Issue 12, December 2026.Adult zebrafish radial glia quiescence is controlled by at least four mechanisms: Notch3, BMP‐Id1, Nr2f1b and Midkine‐a. We propose these act as partially redundant inputs, biased along the antero‐posterior axis that set quiescence depth. ABSTRACT The zebrafish telencephalon is an excellent model for adult neurogenesis under physiological and ...
Mathilde Hoareau +2 more
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, 2015 Abnormal structure and function of astrocytes have been observed within the lamina cribrosa region of the optic nerve head (ONH) in glaucomatous neurodegeneration.
Robert N. Weinreb +15 more
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Microglial Labeling in Mouse Spinal Cord Injury: A Review of Timing, Efficacy, and Specificity
Glia, Volume 74, Issue 12, December 2026.The transcriptional profile of microglia is significantly altered after spinal cord injury (SCI). When choosing a marker to label microglia after SCI, it is important to consider its specificity for microglia and its stability of expression. ABSTRACT Traumatic spinal cord injury (SCI) is a complex and disabling condition with no curative therapy ...
Ruth Colbert +2 more
wiley +1 more source
Glutamate excitotoxicity in transient global cerebral ischemia
Acta Neurobiologiae Experimentalis, 1996 The glutamate excitoxicity hypothesis of ischemic cell damage holds that cell damage caused by transient cerebral ischemia is triggered by glutamate, released during ischemia from the intracellular compartment into the synaptic cleft: high extracellular glutamate levels activate ionotropic glutamate receptors, thus inducing an overflow of calcium ions ...
openaire +2 more sources
Astrocytic EAAT‐2 Upregulation Supports Neuro‐Axonal Homeostasis in Chronic Inflammatory CNS Lesions
Glia, Volume 74, Issue 12, December 2026.Inflammatory CNS lesions increase extracellular glutamate. Astrocytic EAAT regulation controls glutamate clearance, stabilizes axonal Ca2+ homeostasis, and determines neurite survival during chronic neuroinflammation. ABSTRACT Neuronal loss in multiple sclerosis (MS) is a key factor in the progression of disability.
Luise Reukauf +9 more
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Sinapic acid (SA) is a polyphenol compound derived from hydroxycinnamic acid found in various foods such as cereals and vegetables and has antioxidant, anti-inflammatory and neuroprotective properties.
Ortasoz, Ahmet Mahmut +3 more
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Journal of Labelled Compounds and Radiopharmaceuticals, Volume 69, Issue 13-14, November-December 2026.An efficient two‐step radiosynthesis of [18F]RP‐115 was developed using copper‐mediated radiofluorination (CMRF) followed by deprotection. In a total 70‐min synthesis time, this approach provided [18F]RP‐115 in high radiochemical yield (52.8% ± 2.1%, decay corrected from stating [18F]fluoride ion) with high molar activity (355 ± 61 GBq/μmol) and ...
Sang Hee Lee +9 more
wiley +1 more source
Ionotropic glutamate receptors and excitotoxicity
, 2012 Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system and its excitatory role is mediated trough activation of glutamatergic ionotropic receptors which are responsible for synaptic transmission and play an important ...
Skřenková, Kristýna
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