Results 131 to 140 of about 153,025 (224)

Neurodegenerative Diseases: Epidemiology, Risk Factors, Classification, Pathophysiology, Clinical Features, Diagnosis, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neurodegenerative diseases share convergent risk architectures and pathological mechanisms, yet diverge in selective vulnerability, clinical presentation, and therapeutic responsiveness. This review integrates cross‐disease epidemiology, pathophysiology, diagnosis, and treatment, highlighting the transition from symptomatic care toward biomarker‐guided
Zimeng He, Jingjing Zeng, Guoqing Wang, Yuxin Li, Feng Zhang   +4 more
wiley   +1 more source

Fucoxanthin protects retinal ganglion cells and promotes parkin-mediated mitophagy against glutamate excitotoxicity. [PDF]

Neuroreport, 2023
Lian W, Hu X, Zhang J, Wu Y, Zhao N, Ma H, He H, Lu Q.   +7 more
europepmc   +1 more source

Multiple Sclerosis and Viruses: « Liaisons Dangereuses »

Reviews in Medical Virology, Volume 36, Issue 6, November 2026.
ABSTRACT Multiple sclerosis (MS) is a complex, multifactorial neurodegenerative disease with an aetiology that is still partially elusive. Several risk factors are associated with MS development including genetic predisposition and various environmental stressors; however, recently, viral infections have gained significant attention as a crucial ...
Samanta Plavina, Daniela Malakovska, Jolanta Kalnina, Ilva Trapina, Elina Leonova, Mohammed Habib, Susanne Schifmann, Jegors Paramonovs, Nikolajs Sjakste, Yegor Vassetzky, Emmanuel Drouet, Natalia Paramonova   +11 more
wiley   +1 more source

GM1 ganglioside exerts protective effects against glutamate-excitotoxicity via its oligosaccharide in wild-type and amyotrophic lateral sclerosis motor neurons. [PDF]

FEBS Open Bio, 2023
Lunghi G, Di Biase E, Carsana EV, Henriques A, Callizot N, Mauri L, Ciampa MG, Mari L, Loberto N, Aureli M, Sonnino S, Spedding M, Chiricozzi E, Fazzari M.   +13 more
europepmc   +1 more source

Opioid Modulation of Major Neurotransmitter Systems: Acute, Chronic, and Withdrawal Effects

European Journal of Neuroscience, Volume 64, Issue 9, November 2026.
Opioids are widely used but also frequently misused drugs that affect multiple neurotransmitter systems, including dopaminergic, glutamatergic, GABAergic, serotonergic, and cholinergic pathways. Opioid‐induced neuroadaptations depend on the duration of drug exposure, with distinct changes also emerging following drug discontinuation.
Daniela Novakova, Eliska Pritulova, Jiri Novotny   +2 more
wiley   +1 more source

TRP Channels in Excitotoxicity.

Glutamate excitotoxicity is a central mechanism contributing to cellular dysfunction and death in various neurological disorders and diseases, such as stroke, traumatic brain injury, epilepsy, schizophrenia, addiction, mood disorders, Huntington\u27s ...
Feng, Jianlin, Yue, Lixia, Zong, Pengyu, Legere, Nicholas   +3 more
core   +1 more source

Evidence for glutamate-mediated excitotoxic mechanisms during photoreceptor degeneration in the rd1 mouse retina [PDF]

, 2005
PURPOSE: Kinetic studies of photoreceptor cell death in the retinal degeneration (rd1) mouse model suggest that photoreceptor degeneration could result from cumulative damage.
Neveux, N, Forster, V, Picaud, S, Leveillard, T, Sahel, JA, Delyfer, MN   +5 more
core  

The neuroprotective effect of melatonin in glutamate excitotoxicity of R28 cells and mouse retinal ganglion cells. [PDF]

Front Endocrinol (Lausanne), 2022
Wang C, An Y, Xia Z, Zhou X, Li H, Song S, Ding L, Xia X.   +7 more
europepmc   +1 more source

Localisation of glutamate receptors in developing cortical neurons in culture and relationship to susceptibility to excitotoxicity

, 2006
Overactivation of glutamate receptors leading to excitotoxicity has been implicated in the neurodegenerative alterations of a range of central nervous system (CNS) disorders.
Chung, RS (15492110), James Vickers (14751775), Anna King (14741206), Tracey Dickson (14735257)   +3 more
core  

Dendrimer-enabled targeted delivery attenuates glutamate excitotoxicity and improves motor function in a rabbit model of cerebral palsy. [PDF]

J Control Release, 2023
Zhang F, Zhang Z, Alt J, Kambhampati SP, Sharma A, Singh S, Nance E, Thomas AG, Rojas C, Rais R, Slusher BS, Kannan RM, Kannan S.   +12 more
europepmc   +1 more source