Results 81 to 90 of about 153,025 (224)
Molecular Neurodegeneration, 2017 Background Hyperexcitability of neuronal networks can lead to excessive release of the excitatory neurotransmitter glutamate, which in turn can cause neuronal damage by overactivating NMDA-type glutamate receptors and related signaling pathways.
Takashi Miyamoto +7 more
doaj +1 more source
Phytotherapy Research, EarlyView.Schematic illustration showing that Hinokitiol promotes neural repair after spinal cord injury by activating the Keap1/Nrf2/HO‐1 signaling pathway and reprogramming microglial inflammatory‐redox responses. ABSTRACT Secondary neuroinflammation and oxidative stress, driven partly by maladaptive microglial activation, limit recovery after spinal cord ...
Wenhao Zhang +10 more
wiley +1 more source
, 2009 Hippocampal vulnerability to excitotoxicity has been widely studied along with its implication to learning and memory. Neonatal glutamate excitotoxicity induces loss of CA1 pyramidal neurons in adult rats concomitantly with some plastic changes in the ...
Gonzalez-Burgos, I. +5 more
core +1 more source
Chemokine CX3CL1 protects rat hippocampal neurons against glutamate-mediated excitotoxicity.
, 2005 Excitotoxicity is a cell death caused by excessive exposure to glutamate (Glu), contributing to neuronal degeneration in many acute and chronic CNS diseases.
Di Angelantonio S +7 more
core +2 more sources
Data in Brief, 2018 This data article describes the influence of Cimicifuga racemosa extract Ze 450 on neuronal cells in models of glutamate-induced excitotoxicity and cell death induced by oxidative stress.
Malena Rabenau +3 more
doaj +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley +1 more source
Phytotherapy Research, EarlyView.Rh1 attenuates oxidative stress and mitochondrial dysfunction through SIRT1‐related signaling. ABSTRACT Alzheimer's disease (AD) remains a progressive neurodegenerative disorder with limited therapeutic options. Ginsenoside Rh1 has been reported to possess neuroprotective properties, yet its specific role and underlying mechanisms in AD are not fully ...
Shi‐Lu Li +10 more
wiley +1 more source
Glutamate, Excitotoxicity and Releated Diseases
, 2023 Glutamate is an excitatory neurotransmitter that is abundant in many central and peripheral tissues and is essential for cell survival and body homeostasis. Although its existence has been known for many years, research still reveals that excitotoxicity plays a role in the development of new pathological conditions.
BUDAK SAVAŞ, Ayşenur +3 more
openaire +2 more sources
, 2017 34 p.Neurodegenerative diseases affecting the central nervous system are characterized by neuronal impairment or death. One mechanism leading to neuronal death in many neurodegenerative diseases is glutamate excitotoxicity.
Keramidas, Christina
core +1 more source
Chronic glutamate toxicity in neurodegenerative diseases-what is the evidence?
Frontiers in Neuroscience, 2015 Together with aspartate, glutamate is the major excitatory neurotransmitter in the brain. Glutamate binds and activates both ligand-gated ion channels (ionotropic glutamate receptors) and a class of G-protein coupled receptors (metabotropic glutamate ...
Pamela eMaher, Jan eLewerenz
doaj +1 more source