D(-)lentiginosine-induced apoptosis involves the intrinsic pathway and is p53-independent [PDF]
, 2012 We have recently found that D(-)lentiginosine, a synthetic iminosugar exerting glucosidase inhibitory activity, but not its natural enantiomer lentiginosine, is endowed with an unexpected, pro-apoptotic activity. Here, we investigated mechanisms involved
Brandi, A +6 more
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Azasugar Glycosidase Inhibitors: Useful Tools for Glycobiologists
CHIMIA, 1996 Glycosidase inhibitors are moving increasingly as potential agents for the treatment of diseases by altering glycosylation or catabolism of glycoconjugates.
Sylviane Picasso
doaj +2 more sources
Molecules, 1998 Enantiomerically pure, five membered cyclic nitrones, easily obtained in large amounts from protected hydroxyacids and aminoacids such as D- and L-tartaric, L-malic, and L-aspartic acids, give cycloaddition reactions with a good diastereocontrol.
Alberto Brandi +4 more
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Glycosylation inhibitors efficiently inhibit P-selectin-mediated cell adhesion to endothelial cells. [PDF]
PLoS ONE, 2014 Adhesion molecules play a critical role in the adhesive interactions of multiple cell types in sickle cell disease (SCD). We previously showed that anti-P-selectin aptamer efficiently inhibits cell adhesion to endothelial cells (ECs) and permits SCD mice
Pushpankur Ghoshal +3 more
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Saudi Pharmaceutical Journal, 2023 Onion contains many dietary and bioactive components including phenolics and flavonoids. Spiraeoside (quercetin-4-O-β-D-glucoside) is one of the most putative flavonoids in onion.
Lokman Durmaz +4 more
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Identification of a novel 82 kDa proMMP-9 species associated with the surface of leukaemic cells [PDF]
, 2007 MMP-9 (matrix metalloproteinase 9) plays a critical role in tumour progression. Although the biochemical properties of the secreted form of proMMP-9 are well characterized, little is known about the function and activity of cell surface-associated proMMP-
Egea, Virginia +6 more
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Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp2-Iminosugar Glycolipids
Molecules, 2019 The unique stereoelectronic properties of sp2-iminosugars enable their participation in glycosylation reactions, thereby behaving as true carbohydrate chemical mimics.
Elena M. Sánchez-Fernández +6 more
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Advances in the synthesis of Homochiral (-)-1-azafagomine and (+)-5-epi-1-azafagomine. 1-N-phenyl carboxamide derivatives of both enantiomers of 1-azafagomine: leads for the synthesis of active α-Glycosidase inhibitors [PDF]
, 2011 - A new expeditious preparation of homochiral (-)-1-azafagomine, and (+)-5-epi-1-azafagomine has been devised. Stoodley´s diastereoselective cycloaddition of dienes bearing a 2,3,4,6-tetraacetyl glucosyl chiral auxiliary to 4-phenyl-1,2,4-triazole-3,5 ...
Alves, M. José +5 more
core +1 more source
Synthesis and biological evaluation of nojirimycin- and pyrrolidine-based trehalase inhibitors
Beilstein Journal of Organic Chemistry, 2012 A small set of nojirimycin- and pyrrolidine-based iminosugar derivatives has been synthesized and evaluated as potential inhibitors of porcine and insect trehalases.
Davide Bini +6 more
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Molecules, 2018 A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern (d-gluco or l-ido), the architecture of the glycone skeleton, and the nature of the nonglycone substituent has been synthesized and ...
Teresa Mena-Barragán +9 more
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