Results 61 to 70 of about 16,712 (156)

Glycosylation pattern of brush border-associated glycoproteins in enterocyte-like cells: involvement of complex-type N-glycans in apical trafficking [PDF]

, 2009
We have previously reported that galectin-4, a tandem repeat-type galectin, regulates the raft-dependent delivery of glycoproteins to the apical brush border membrane of enterocyte-like HT-29 cells.
Altschuler Y., Gabius H.J., Gendler S., Gouyer V., Hennebicq-Reig S., Huang J., Ligtenberg M.J., Ninomiya H., Yamashita K.   +8 more
core   +3 more sources

Synthetic applications of chiral unsaturated epoxy alcohols prepared by sharpless asymmetric epoxidation [PDF]

, 2010
An overview of the synthesis and applications of chiral 2,3-epoxy alcohols containing unsaturated chains is presented. One of the fundamental synthetic routes to these compounds is Sharpless asymmetric epoxidation, which is reliable, highly ...
Moreno, María, Riera i Escalé, Antoni
core   +2 more sources

A novel CAV derived cell-penetrating peptide efficiently delivers exogenous molecules through caveolae-mediated endocytosis

Veterinary Research, 2018
Cell-penetrating peptide (CPP) is a promising cargo for delivering bioactive molecules. In this study, the N terminus of VP1 from chicken anemia virus, designated as CVP1, was found to carry enriched arginine residues with α-helix.
Gaowei Hu, Wenlv Zheng, Ao Li, Yaru Mu, Mingyu Shi, Tuofan Li, Haitao Zou, Hongxia Shao, Aijian Qin, Jianqiang Ye   +9 more
doaj   +1 more source

A Specific Activity-Based Probe to Monitor Family GH59 Galactosylceramidase, the Enzyme Deficient in Krabbe Disease [PDF]

, 2017
Galactosylceramidase (GALC) is the lysosomal β-galactosidase responsible for the hydrolysis of galactosylceramide. Inherited deficiency in GALC causes Krabbe disease, a devastating neurological disorder characterized by accumulation of galactosylceramide
Aerts, Johannes M F G, Biela-Banas, Anna, Boot, Rolf G., Cachón‐González, M. Begoña, Cox, Timothy M., Florea, Bogdan I., Herrera Moro, Daniela, Kallemeijn, Wouter W., Kim, Nee Na, Marques, André R. A., Martin, Olivier R., Nelson, Jessica K., Ottenhoff, Roelof, Overkleeft, Herman S., Scheij, Saskia, van Roomen, Cindy P.A.A., Verhoek, Marri, Willems, Lianne I.   +17 more
core   +1 more source

General Method for the Synthesis of (−)-Conduritol C and Analogs from Chiral Cyclohexadienediol Scaffolds

Molecules, 2018
An efficient and facile general method for the synthesis of conduritol C analogs, taking advantage of an enantioselective biocatalysis process of monosubstituted benzenes, is described. The absolute stereochemical patterns of the target molecules (−
Gaurao D. Tibhe, Mario A. Macías, Valeria Schapiro, Leopoldo Suescun, Enrique Pandolfi   +4 more
doaj   +1 more source

Activity-based probes for functional interrogation of retaining β-glucuronidases [PDF]

, 2017
Humans express at least two distinct β-glucuronidase enzymes that are involved in disease: exo-acting β-glucuronidase (GUSB), whose deficiency gives rise to mucopolysaccharidosis type VII, and endo-acting heparanase (HPSE), whose overexpression is ...
Aerts, Johannes M.F.G., Artola, Marta, Codée, Jeroen D.C., Dai, Wei, Davies, Gideon J., Florea, Bogdan I., Jiang, Jianbing, Jin, Yi, Kallemeijn, Wouter W., Kuo, Chi Lin, Overkleeft, Herman S., Van Der Marel, Gijsbert A., Van Eijk, Marco, Van Elk, Cas, Wu, Liang   +14 more
core   +2 more sources

Straightforward chemo-enzymatic synthesis of new aminocyclitols, analogues of valiolamine and their evaluation as glycosidase inhibitors. [PDF]

, 2006
An efficient fructose-1,6-bisphosphate aldolase mediated synthesis of new aminocyclitol analogues of valiolamine is described. The one-pot process where four stereocentres are created involves the formation of two carbon–carbon bonds. One is catalysed by
Ahbala, Mustapha, Bolte, Jean, El Blidi, Lahssen, Lemaire, Marielle   +3 more
core   +3 more sources

Monosaccharide and Disaccharide Mimics: New Molecular Tools for Biology and Medicine

CHIMIA, 2001
Intercellular communication is governed by interactions between surface oligosaccharides and glycoproteins. The biosynthesis of these molecules involves glycosidations catalyzed by glycosyltransferases and hydrolysis of O-glycosyl linkages ...
Pierre Vogel
doaj  

Anticholinergic, antidiabetic and antioxidant activities of cinnamon (cinnamomum verum) bark extracts: polyphenol contents analysis by LC-MS/MS

International Journal of Food Properties, 2019
Ethanolic (EEC) and aqueous (WEC) extracts of cinnamon (Cinnamomum verum) were evaluated for their antioxidant profiles by eight distinguished bioanalytical antioxidant methods.
Ilhami Gulcin, Ruya Kaya, Ahmet C. Goren, Hulya Akincioglu, Meryem Topal, Zeynebe Bingol, Kader Cetin Çakmak, Sevim B. Ozturk Sarikaya, Lokman Durmaz, Saleh Alwasel   +9 more
doaj   +1 more source

Synthesis and Cytotoxic Evaluation of 1H-1,2,3-Triazol-1-ylmethyl-2,3-dihydronaphtho[1,2-b]furan-4,5-diones

Anais da Academia Brasileira de Ciências, 2018
The 1,2-naphthoquinone compound was previously considered active against solid tumors. Moreover, glycosidase inhibitors such as 1,2,3-1H triazoles has been pointed out as efficient compounds in anticancer activity studies.
INGRID C. CHIPOLINE, EVELYNE ALVES, PAOLA BRANCO, LETICIA V. COSTA-LOTUFO, VITOR F. FERREIRA, FERNANDO C. DA SILVA   +5 more
doaj   +1 more source