Results 1 to 10 of about 10,037 (210)

Emerging gut microbial glycoside hydrolase inhibitors. [PDF]

RSC Chem Biol
Glycoside hydrolase inhibitors are emerging as valuable tools to study gut microbial enzymes that modulate host physiology and disease by degrading dietary, drug-related, and host-derived glycans.
Kowalewski ME, Redinbo MR.
europepmc   +4 more sources

Characterization of Two Wheat-Derived Glycoside Hydrolase Family-10 Xylanases Resistant to Xylanase Inhibitors [PDF]

Journal of Food Quality, 2022
Xylanase inhibitors inhibit the activities of microbial xylanases and seriously compromise the efficacy of microbial xylanases added to modify cereals.
Fangfang Liang, Yi Mo, Suleman Shah, Ying Xie, Arshad Mehmood, Hesheng Jiang, Yafen Guo   +6 more
doaj   +3 more sources

Discovery of Kasugamycin as a Potent Inhibitor of Glycoside Hydrolase Family 18 Chitinases [PDF]

Frontiers in Molecular Biosciences, 2021
Kasugamycin, a well-known aminoglycoside antibiotic, has been used widely in agriculture and medicine to combat microbial pathogens by binding the ribosome to inhibit translation. Here, kasugamycin was discovered to be a competitive inhibitor of glycoside hydrolase family 18 (GH18) chitinases from three different organisms (bacterium, insect and human).
Huitang Qi, Xi Zhuo Jiang, Yi Ding, Tian Liu, Qing Yang   +4 more
openalex   +4 more sources

Allylic Carbocyclic Inhibitors Covalently Bind Glycoside Hydrolases

JACS Au, 2023
Allylic cyclitols were investigated as covalent inhibitors of glycoside hydrolases by chemical, enzymatic, proteomic, and computational methods. This approach was inspired by the C7 cyclitol natural product streptol glucoside, which features a potential carbohydrate leaving group in the 4-position (carbohydrate numbering).
Tatyana D. Grayfer, Khalil Yamani, Erik Jung, Gleb A. Chesnokov, Isabella Ferrara, Chien‐Chi Hsiao, Antri Georgiou, Jeremy Michel, Aurélien Bailly, Simon Sieber, Leo Eberl, Karl Gademann   +11 more
openalex   +3 more sources

Zwitterionic pyrrolidene-phosphonates: inhibitors of the glycoside hydrolase-like phosphorylase Streptomyces coelicolor GlgEI-V279S [PDF]

Organic & Biomolecular Chemistry, 2017
We synthesized and evaluated new zwitterionic inhibitors against glycoside hydrolase-like phosphorylaseStreptomyces coelicolor(Sco) GlgEI-V279S which plays a role in α-glucan biosynthesis.
Sri Kumar Veleti, Cécile Petit, Donald R. Ronning, Steven J. Sucheck   +3 more
openalex   +4 more sources

Emergence of a subfamily of xylanase inhibitors within glycoside hydrolase family 18 [PDF]

The FEBS Journal, 2005
The xylanase inhibitor protein I (XIP‐I), recently identified in wheat, inhibits xylanases belonging to glycoside hydrolase families 10 (GH10) and 11 (GH11). Sequence and structural similarities indicate that XIP‐I is related to chitinases of family GH18, despite its lack of enzymatic activity.
Anne Durand, R.C. Hughes, Alain Roussel, Ruth H. Flatman, Bernard Henrissat, Nathalie Juge   +5 more
  +6 more sources

Fully Deacetylated Chitooligosaccharides Act as Efficient Glycoside Hydrolase Family 18 Chitinase Inhibitors [PDF]

Journal of Biological Chemistry, 2014
Small molecule inhibitors against chitinases have potential applications as pesticides, fungicides, and antiasthmatics. Here, we report that a series of fully deacetylated chitooligosaccharides (GlcN)2-7 can act as inhibitors against the insect chitinase OfChtI, the human chitinase HsCht, and the bacterial chitinases SmChiA and SmChiB with IC50 values ...
Lei Chen, Yong Zhou, Mingbo Qu, Yong Zhao, Qing Yang   +4 more
  +6 more sources

Glycoside hydrolase stabilization of transition state charge: new directions for inhibitor design

Chemical Science, 2020
Positive charge stabilized on remote C5-allylic center with catalysis occurringviaa loose SN2 transition state.
Weiwu Ren, Marco Farren‐Dai, Natalia Sannikova, Katarzyna Świderek, Yang Wang, Oluwafemi Akintola, Robert Britton, Vicent Moliner, Andrew J. Bennet   +8 more
openalex   +5 more sources

Small Molecule Inhibitors of a Glycoside Hydrolase Attenuate Inducible AmpC-mediated β-Lactam Resistance [PDF]

Journal of Biological Chemistry, 2007
The increasing spread of plasmid-borne ampC-ampR operons is of considerable medical importance, since the AmpC beta-lactamases they encode confer high level resistance to many third generation cephalosporins. Induction of AmpC beta-lactamase from endogenous or plasmid-borne ampC-ampR operons is mediated by a catabolic inducer molecule, 1,6-anhydro-N ...
Keith A. Stubbs, M.D. Balcewich, Brian L. Mark, David J. Vocadlo   +3 more
openalex   +4 more sources

His374 of wheat endoxylanase inhibitor TAXI‐I stabilizes complex formation with glycoside hydrolase family 11 endoxylanases [PDF]

The FEBS Journal, 2005
Wheat endoxylanase inhibitor TAXI‐I inhibits microbial glycoside hydrolase family 11 endoxylanases. Crystallographic data of an Aspergillus niger endoxylanase‐TAXI‐I complex showed His374 of TAXI‐I to be a key residue in endoxylanase inhibition [Sansen S, De Ranter CJ, Gebruers K, Brijs K, Courtin CM, Delcour JA & Rabijns A (2004) J Biol Chem 279 ...
Katleen Fierens, Ann Gils, Stefaan Sansen, Kristof Brijs, Christophe M. Courtin, Paul Declerck, C. J. De Ranter, Kurt Gebruers, Anja Rabijns, Johan Robben, Steven Van Campenhout, Guido Volckaert, Jan A. Delcour   +12 more
openalex   +4 more sources