Results 11 to 20 of about 10,037 (210)
Structural insights into the inhibition mechanism of glucosidase inhibitors toward kojibiose hydrolase belonging to glycoside hydrolase family 65 [PDF]
Bioscience, Biotechnology, and BiochemistryAbstract Glycoside hydrolase family 65 (GH65) includes glycoside hydrolases active on various α-glucosides. We previously demonstrated that the GH65 enzyme from Flavobacterium johnsoniae (FjGH65A) is a kojibiose hydrolase and determined its 3-dimensional structure. In this study, the effects of glucosidase inhibitors on FjGH65A and their
Shuntaro Nakamura, Takatsugu Miyazaki
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Journal of Applied Glycoscience, 2011 Azasugars are known as potent inhibitors of glycoside hydrolases. In this study, we examined the inhibition of Cellvibrio gilvus cellobiose phosphorylase (CBP) by four azasugars (isofagomine, 1-deoxynojirimycin, castanospermine and calystegine B2) and a non-azasugar (glucono-1,5-lactone).
Shinya Fushinobu +5 more
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Mechanism-Based Allylic Carbasugar Chlorides That Form Covalent Intermediates with α- and β-Galactosidases [PDF]
MoleculesGlycoside hydrolases have been implicated in a wide range of human conditions including lysosomal storage diseases. Consequently, many researchers have directed their efforts towards identifying new classes of glycoside hydrolase inhibitors, both ...
Oluwafemi Akintola +2 more
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Organic & Biomolecular Chemistry, 2017 Correction for ‘Zwitterionic pyrrolidene-phosphonates: inhibitors of the glycoside hydrolase-like phosphorylase Streptomyces coelicolor GlgEI-V279S’ by Sri Kumar Veleti et al., Org. Biomol. Chem., 2017, 15, 3884–3891.
Sri Kumar Veleti +4 more
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, 2017 Plant cell walls are composed mostly of polysaccharides and it consist of three layers (the primary cell wall, the secondary cell wall and the middle lamella) that are made up of different percentage of cellulose, pectins and hemicelluloses. These latter are composed of a linear backbone made up of (1,4)-?-D-glycans with an equatorial configuration ...
Elisabetta Galanti
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Synthesis of conformationally constrained inhibitors for glycoside hydrolases
, 2019 Glycoside hydrolase (GH) enzymes are clinically relevant biological targets for drug development. Disfunction of the two lysosomal GHs β-glucocerebrosidase and α-galactosidase can lead to Gaucher and Fabry’s disease, respectively. With knowledge of their mechanisms of action it is possible to create compounds that would effectively modulate their ...
O. B. Sannikov
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Biomedicine & Pharmacotherapy, 2019 Bauhinia forficata Link., a cerrado native plant, is used as a complementary treatment for Type 2 Diabetes Mellitus (T2DM). Several studies involving this plant have shown that it has prominent potential to combat hyperglycemia and oxidative stress. Our objective was suggest the phytochemical constitution of fractions of ethanol extract of B. forficata
Rodrigo Rodrigues Franco +7 more
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Designing selective inhibitors to target NagZ a family 3 glycoside hydrolase [PDF]
Acta Crystallographica Section A Foundations of Crystallography, 2008 M.D. Balcewich +4 more
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The effect of carbohydrate binding modules and linkers on inhibitor binding to family 18 glycoside hydrolases [PDF]
The Journal of Chemical Thermodynamics, 2018 Abstract Enzyme catalyzed hydrolysis of glycosidic bonds is undertaken by glycoside hydrolases (GHs) in nature. In addition to a catalytic domain (CD), GHs often have carbohydrate-binding modules (CBMs) attached to the CD through a linker. Allosamidin binding to full-length GH18 Serratia marcescens ChiB and the catalytic domain only yield equal ...
Kristine Bistrup Eide, Morten Sørlie
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Structural analysis of a newly identified class of plant protective microbial glycoside hydrolase inhibitors [PDF]
Acta Crystallographica Section A Foundations of Crystallography, 2004 Stefaan Sansen +6 more
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