Results 21 to 30 of about 10,037 (210)

High resolution crystal structure of the Endo-N-acetyl-beta-D-glucosaminidase responsible for the deglycosylation of hypocrea jecorina cellulases [PDF]

, 2012
Endo-N-acetyl-beta-D-glucosaminidases (ENGases) hydrolyze the glycosidic linkage between the two N-acetylglucosamine units that make up the chitobiose core of N-glycans. The endo-N-acetyl-beta-D-glucosaminidases classified into glycoside hydrolase family
Anita Van Landschoot, Bart Devreese, Ingeborg Stals, Mats Sandgren, Michael Ward, Renwick Dobson, Saeid Karkehabadi, Steve Kim   +7 more
core   +17 more sources

Characterization of Glycoside Hydrolase Families 13 and 31 Reveals Expansion and Diversification of α-Amylase Genes in the Phlebotomine Lutzomyia longipalpis and Modulation of Sandfly Glycosidase Activities by Leishmania Infection

Frontiers in Physiology, 2021
Sugar-rich food sources are essential for sandflies to meet their energy demands, achieving more prolonged survival. The digestion of carbohydrates from food is mainly realized by glycoside hydrolases (GH). To identify genes coding for α-glycosidases and
Samara Graciane da Costa-Latgé, Paul Bates, Rod Dillon, Rod Dillon, Fernando Ariel Genta, Fernando Ariel Genta   +5 more
doaj   +1 more source

Structural and Functional Characterization of Drosophila melanogaster α-Amylase

Molecules, 2023
Insects rely on carbohydrates such as starch and glycogen as an energy supply for growth of larvae and for longevity. In this sense α-amylases have essential roles under extreme conditions, e.g., during nutritional or temperature stress, thereby ...
Moez Rhimi, Jean-Luc Da Lage, Richard Haser, Georges Feller, Nushin Aghajari   +4 more
doaj   +1 more source

Targeting N-Terminal Human Maltase-Glucoamylase to Unravel Possible Inhibitors Using Molecular Docking, Molecular Dynamics Simulations, and Adaptive Steered Molecular Dynamics Simulations

Frontiers in Chemistry, 2021
There are multiple drugs for the treatment of type 2 diabetes, including traditional sulfonylureas biguanides, glinides, thiazolidinediones, α-glucosidase inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, dipeptidyl peptidase IV (DPP-4 ...
Shitao Zhang, Yi Wang, Lu Han, Xueqi Fu, Song Wang, Wannan Li, Weiwei Han   +6 more
doaj   +1 more source

Exploration of the Transglycosylation Activity of Barley Limit Dextrinase for Production of Novel Glycoconjugates

Molecules, 2023
A few α-glucan debranching enzymes (DBEs) of the large glycoside hydrolase family 13 (GH13), also known as the α-amylase family, have been shown to catalyze transglycosylation as well as hydrolysis. However, little is known about their acceptor and donor
Malene Bech Vester-Christensen, Jesper Holck, Martin Rejzek, Léa Perrin, Morten Tovborg, Birte Svensson, Robert A. Field, Marie Sofie Møller   +7 more
doaj   +1 more source

Design of Novel Benzimidazole Derivatives as Potential α-amylase Inhibitors by 3D-QSAR Modeling and Molecular Docking Studies

Journal of the Turkish Chemical Society, Section A: Chemistry, 2020
The α-amylase is an enzyme of a highly conserved glycoside hydrolase family, α-amylase inhibitors can be used as clinical agents for the treatment of Diabetes Mellitus (DM). A 3D-QSAR study was performed on 45 2-aryl benzimidazole derivatives, which have
Khalil EL KHATABİ, İlham AANOUZ, Reda EL-MERNİSSİ, Ayoub KHALDAN, Mohammed Aziz AJANA, Mohammed BOUACHRINE, Tahar LAKHLIFI   +6 more
doaj   +1 more source

Characterization of glycoside hydrolase family 11 xylanase from Streptomyces sp. strain J103; its synergetic effect with acetyl xylan esterase and enhancement of enzymatic hydrolysis of lignocellulosic biomass

Microbial Cell Factories, 2021
Background Xylanase-containing enzyme cocktails are used on an industrial scale to convert xylan into value-added products, as they hydrolyse the β-1,4-glycosidic linkages between xylopyranosyl residues.
Svini Dileepa Marasinghe, Eunyoung Jo, Sachithra Amarin Hettiarachchi, Youngdeuk Lee, Tae-Yang Eom, Yehui Gang, Yoon-Hyeok Kang, Chulhong Oh   +7 more
doaj   +1 more source

A unique self-truncation of bacterial GH5 endoglucanases leads to enhanced activity and thermostability

BMC Biology, 2022
Background β-1,4-endoglucanase (EG) is one of the three types of cellulases used in cellulose saccharification during lignocellulosic biofuel/biomaterial production. GsCelA is an EG secreted by the thermophilic bacterium Geobacillus sp.
Mei-Huey Wu, Mu-Rong Kao, Chen-Wei Li, Su-May Yu, Tuan-Hua David Ho   +4 more
doaj   +1 more source

Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases. [PDF]

, 2015
MutY adenine glycosylases prevent DNA mutations by excising adenine from promutagenic 8-oxo-7,8-dihydroguanine (OG):A mismatches. Here, we describe structural features of the MutY active site bound to an azaribose transition state analog which indicate a
Cao, Sheng, Chu, Aurea, David, Sheila S, Horvath, Martin P, O'Shea, Valerie L, Richards, Jody L, Woods, Ryan D   +6 more
core   +2 more sources

Crystal structure-guided design of berberine-based novel chitinase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Glycoside hydrolase family 18 (GH18) chitinases play an important role in various organisms ranging from bacteria to mammals. Chitinase inhibitors have potential applications as pesticides, fungicides, and anti-asthmatics.
Lei Chen, Ling Zhu, Jinli Chen, Wei Chen, Xuhong Qian, Qing Yang   +5 more
doaj   +1 more source