Results 31 to 40 of about 10,037 (210)

O-GlcNAcase:promiscuous hexosaminidase or key regulator of O-GlcNAc signalling? [PDF]

, 2014
O-GlcNAc signaling is regulated by an opposing pair of enzymes: O-GlcNAc transferase installs and O-GlcNAcase (OGA) removes the modification from proteins.
Banerjee, Butkinaree, Cantarel, Cecioni, Cetinba, Comtesse, Copeland, Dennis, Dong, Dorfmueller, Dorfmueller, Drougat, Forsythe, Francisco, Gao, Gong, Graham, Guinez, Hanover, Hart, Hayakawa, He, He, Heckel, Hilgers, Housley, Howerton, Hu, Itkonen, Keembiyehetty, Knapp, Laczy, Lefebvre, Lepage, Libina, Liu, Macauley, Macauley, Macauley, Macauley, Macauley, Mahuran, Martin, Minami, Müller, Nagel, Olszewski, Ostrowski, Pathak, Penton, Radermacher, Rahman, Rao, Rao, Robinson, Ruan, Ruan, Schimpl, Schimpl, Schultz, Sekine, Shen, Slawson, Speakman, Stryke, Swallow, Tews, Toleman, Toleman, Torres, Wang, Wang, Webster, Wells, Whisenhunt, Whitworth, Yang, Yu, Yuzwa, Yuzwa, Zachara, Zachara, Zhu   +82 more
core   +3 more sources

My Times with Professor Igor Kregar and some Hydrolytic Enzymes

Acta Chimica Slovenica, 2019
The late Professor Igor Kregar and this author had several overlapping biochemical research interests. One focus was the glycoside hydrolase, lysozyme, and the other was proteolytic enzymes and their inhibitors, in particular those present in tissues ...
Karl J. Kramer
doaj   +1 more source

The development and use of small molecule inhibitors of glycosphingolipid metabolism for lysosomal storage diseases

Journal of Lipid Research, 2014
Glycosphingolipid (GSL) storage diseases have been the focus of efforts to develop small molecule therapeutics from design, experimental proof of concept studies, and clinical trials.
James A. Shayman, Scott D. Larsen
doaj   +1 more source

A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of β-N-acetylglucosaminidases [PDF]

, 2007
The synthesis of an analogue of 6-epi-valienamine bearing an acetamido group and its characterisation as an inhibitor of β-N-acetylglucosaminidases are described.
Adrian Scaffidi, Backvall, Bailey, Beer, Chen, Chretien, David J. Vocadlo, Davies, Davies, Dennis, Dong, Dorfmueller, Edward J. Taylor, Emsley, Esnouf, Fairweather, Gideon J. Davies, Horsch, Junge, Kappes, Keith A. Stubbs, Knapp, Kraulis, Legler, Lin, Liu, Liu, Macauley, Mark, Money, Murshudov, Namiki, Nicotra, Ogawa, Rana, Rao, Rebecca J. Dennis, Robert V. Stick, Salleh, Scaffidi, Shanmugasundaram, Shitara, Sigurskjold, Stubbs, Stubbs, Svensson, Tanaka, Terinek, Tews, Vocadlo   +49 more
core   +1 more source

Microbial xylanases and their inhibition by specific proteins in cereals

Kvasný průmysl, 2019
Arabinoxylans (AXs) belong to the components of plant cells which are mainly degraded by microbial xylanases during colonization of grain by phytopathogens.
Daniela Chmelová, Dominika Škulcová, Miroslav Ondrejovic   +2 more
doaj   +1 more source

Iminosugar inhibitors of carbohydrate-active enzymes that underpin cereal grain germination and endosperm metabolism [PDF]

, 2016
Starch is a major energy store in plants. It provides most of the calories in the human diet and, as a bulk commodity, it is used across broad industry sectors.
Alison M. Smith, Andriotis, Andriotis, Aoki, Asano, Asano, Bak-Jensen, Banik, Birte Svensson, Blackwell, Boisson, Burn, Burton, Burton, Chandrasekar, Chavez Montes, Comparot-Moss, Daussant, Dinges, Fincher, Finnie, Frandsen, Gibbons, Hatzfeld, Hickes, Holdsworth, Ichinose, Kihara, Kim, Kolodziejek, Lagaert, Lee, Lee, MacGregor, Martin Rejzek, Mega, Michael D. Rugen, Moreno-Risueno, Møller, Nash, O'Brien, Rejzek, Ritchie, Robert A. Field, Ruzanski, Sissons, Slade, Smith, Smith, Sonnewald, Soussillane, Stanley, Tanaka, Vasilios M. E. Andriotis, Vriet, Wheeler, Winchester, Zeeman   +57 more
core   +2 more sources

Glycoside hydrolase activities of thermophilic bacterial consortia adapted to switchgrass [PDF]

, 2011
Industrial-scale biofuel production requires robust enzymatic cocktails to produce fermentable sugars from lignocellulosic biomass. Thermophilic bacterial consortia are a potential source of cellulases and hemicellulases adapted to harsher reaction ...
Gladden, John M., Allgaier, Martin, Miller, Christopher S., Hazen, Terry C., VanderGheynst, Jean S., Hugenholtz, Philip, Simmons, Blake A., Singer, Steven W.   +7 more
core   +3 more sources

Structural snapshots for mechanism-based inactivation of a glycoside hydrolase by cyclopropyl carbasugars [PDF]

, 2016
This work was supported by an NSERC Discovery Grant (AJB: #121348-2012), a Wellcome Trust Career Development Fellowship (TMG: grant 095828), a Wellcome Trust Institutional Strategic Support award (TMG and RJP), a MSFHR Career Investigator Award (RB), a ...
Bergeron-Brlek, Bergeron-Brlek, Bergeron-Brlek, Blakemore, Chakladar, Doyle, Friedrich, Grondal, Grondal, Lowry, Merceron, Michal, Schramm, Schramm, Schramm, Schwarz, Sinnott, Sinnott, Sinnott, Vocadlo, Vocadlo, Withers, Wolfenden, Wolfenden   +23 more
core   +1 more source

Genome-wide analysis of excretory/secretory proteins in Echinococcus multilocularis: insights into functional characteristics of the tapeworm secretome [PDF]

, 2015
Venn diagrams of expression levels of ES protein coding genes in different developments. The venn diagrams are displayed for: the genes that have expressions (A), the genes with very high expression levels (B), the genes with high expression levels (C ...
Shuai Wang, Wei Wei, Xuepeng Cai
core   +8 more sources

1,6-Cyclophellitol Cyclosulfates : A New Class of Irreversible Glycosidase Inhibitor [PDF]

, 2017
The essential biological roles played by glycosidases, coupled to the diverse therapeutic benefits of pharmacologically targeting these enzymes, provide considerable motivation for the development of new inhibitor classes.
Aerts, Johannes M.F.G., Artola, Marta, Breen, Imogen Z., Codée, Jeroen D.C., Davies, Gideon J., Ferraz, Maria J., Kuo, Chi Lin, Offen, Wendy A., Overkleeft, Herman S., Raich, Lluís, Rovira, Carme, Van Der Marel, Gijsbert A., Wu, Liang   +12 more
core   +9 more sources