Results 1 to 10 of about 36,633 (265)

Lipidomics of Glycosphingolipids [PDF]

Metabolites, 2012
Glycosphingolipids (GSLs) contain one or more sugars that are attached to a sphingolipid moiety, usually to a ceramide, but in rare cases also to a sphingoid base.
Hany Farwanah, Thomas Kolter
doaj   +5 more sources

Glycosphingolipids and neuroinflammation in Parkinson’s disease

Molecular Neurodegeneration, 2020
Parkinson's disease is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons of the nigrostriatal pathway and the formation of neuronal inclusions known as Lewy bodies.
Karim Belarbi, Elodie Cuvelier, Marie-Amandine Bonte, Mazarine Desplanque, Bernard Gressier, David Devos, Marie-Christine Chartier-Harlin   +6 more
doaj   +2 more sources

Characterization of Cell Glycocalyx with Mass Spectrometry Methods [PDF]

Cells, 2019
The cell membrane plays an important role in protecting the cell from its extracellular environment. As such, extensive work has been devoted to studying its structure and function.
Qiongyu Li, Yixuan Xie, Maurice Wong, Carlito B. Lebrilla   +3 more
doaj   +4 more sources

Dysregulated metabolism of ceramides and glycosphingolipids in Parkinson’s disease [PDF]

Journal of Lipid Research
Alterations in sphingolipid metabolism have been implicated in the pathogenesis of Parkinson's disease (PD), yet findings regarding peripheral sphingolipid changes remain inconsistent.
Yu-Fong Peng, Szu-Ju Chen, Jeng-Lin Li, Chin-Hsien Lin, Ching-Hua Kuo   +4 more
doaj   +2 more sources

Aeromonas salmonicida binds α2-6 linked sialic acid, which is absent among the glycosphingolipid repertoires from skin, gill, stomach, pyloric caecum, and intestine

Virulence, 2022
Carbohydrates can both protect against infection and act as targets promoting infection. Mucins are major components of the slimy mucus layer covering the fish epithelia.
John Benktander, Henrik Sundh, Sinan Sharba, Susann Teneberg, Sara K. Lindén   +4 more
doaj   +1 more source

Glycolysis regulates KRAS plasma membrane localization and function through defined glycosphingolipids

Nature Communications, 2023
Oncogenic KRAS expression generates a metabolic dependency on aerobic glycolysis, known as the Warburg effect. We report an effect of increased glycolytic flux that feeds into glycosphingolipid biosynthesis and is directly linked to KRAS oncogenic ...
Junchen Liu, Ransome van der Hoeven, Walaa E. Kattan, Jeffrey T. Chang, D. Montufar‐Solis, Wei V. Chen, M. Wong, Yong Zhou, C. Lebrilla, J. Hancock   +9 more
semanticscholar   +1 more source

Glucosylceramide and galactosylceramide, small glycosphingolipids with significant impact on health and disease

Glycobiology, 2021
Numerous clinical observations and exploitation of cellular and animal models indicate that glucosylceramide (GlcCer) and galactosylceramide (GalCer) are involved in many physiological and pathological phenomena.
Safoura Reza, M. Ugorski, J. Suchański
semanticscholar   +1 more source

The repertoire of glycosphingolipids recognized by Vibrio cholerae. [PDF]

PLoS ONE, 2013
The binding of cholera toxin to the ganglioside GM1 as the initial step in the process leading to diarrhea is nowadays textbook knowledge. In contrast, the knowledge about the mechanisms for attachment of Vibrio cholerae bacterial cells to the intestinal
John Benktander, Jonas Ångström, Hasse Karlsson, Omid Teymournejad, Sara Lindén, Michael Lebens, Susann Teneberg   +6 more
doaj   +1 more source

Glycosphingolipids Recognized by Acinetobacter baumannii

Microorganisms, 2020
Acinetobacter baumannii is an opportunistic bacterial pathogen associated with hospital-acquired infections, including pneumonia, meningitis, bacteremia, urinary tract infection, and wound infections.
Miralda Madar Johansson, Mehjar Azzouz, Beatrice Häggendal, Karin Säljö, Henri Malmi, Anton Zavialov, Susann Teneberg   +6 more
doaj   +1 more source

Review and Proposal of Alternative Technologies for Comprehensive and Reliable Newborn Screening Using Paper Borne Urine Samples for Lysosomal Storage Disorders: Glycosphingolipid Disorders

Journal of Inborn Errors of Metabolism and Screening, 2021
Few current methods are efficient to detect a high number of lysosomal storage disorders (LSDs) in newborn screening. Therefore, we propose a stepwise procedure that starts with the use of paper borne urine samples (Berry-Woolf specimen) for the ...
José Ramón Alonso-Fernández, Javier Fidalgo López   +1 more
doaj   +1 more source