Results 1 to 10 of about 25,840 (267)

Glycosphingolipids and neuroinflammation in Parkinson’s disease

Molecular Neurodegeneration, 2020
Parkinson's disease is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons of the nigrostriatal pathway and the formation of neuronal inclusions known as Lewy bodies.
Karim Belarbi, Elodie Cuvelier, Marie-Amandine Bonte, Mazarine Desplanque, Bernard Gressier, David Devos, Marie-Christine Chartier-Harlin   +6 more
doaj   +2 more sources

Synthesis of Azide-Labeled β-Lactosylceramide Analogs Containing Different Lipid Chains as Useful Glycosphingolipid Probes [PDF]

Molecules
β-Lactosylceramide (β-LacCer) is not only a key intermediate in the biosynthesis of complex glycosphingolipids (GSLs) but also an important regulator of many biological processes.
Basant Mohamed, Rajendra Rohokale, Xin Yan, Amany M. Ghanim, Nermine A. Osman, Hanan A. Abdel-Fattah, Zhongwu Guo   +6 more
doaj   +2 more sources

Dysregulated metabolism of ceramides and glycosphingolipids in Parkinson’s disease [PDF]

Journal of Lipid Research
Alterations in sphingolipid metabolism have been implicated in the pathogenesis of Parkinson's disease (PD), yet findings regarding peripheral sphingolipid changes remain inconsistent.
Yu-Fong Peng, Szu-Ju Chen, Jeng-Lin Li, Chin-Hsien Lin, Ching-Hua Kuo   +4 more
doaj   +2 more sources

Aeromonas salmonicida binds α2-6 linked sialic acid, which is absent among the glycosphingolipid repertoires from skin, gill, stomach, pyloric caecum, and intestine

Virulence, 2022
Carbohydrates can both protect against infection and act as targets promoting infection. Mucins are major components of the slimy mucus layer covering the fish epithelia.
John Benktander, Henrik Sundh, Sinan Sharba, Susann Teneberg, Sara K. Lindén   +4 more
doaj   +1 more source

Glycolysis regulates KRAS plasma membrane localization and function through defined glycosphingolipids

Nature Communications, 2023
Oncogenic KRAS expression generates a metabolic dependency on aerobic glycolysis, known as the Warburg effect. We report an effect of increased glycolytic flux that feeds into glycosphingolipid biosynthesis and is directly linked to KRAS oncogenic ...
Junchen Liu, Ransome van der Hoeven, Walaa E. Kattan, Jeffrey T. Chang, D. Montufar‐Solis, Wei V. Chen, Maurice Wong, Yong Zhou, C. Lebrilla, J. Hancock   +9 more
semanticscholar   +1 more source

Cancer-Associated Glycosphingolipids as Tumor Markers and Targets for Cancer Immunotherapy

International Journal of Molecular Sciences, 2021
Aberrant expression of glycosphingolipids is a hallmark of cancer cells and is associated with their malignant properties. Disialylated gangliosides GD2 and GD3 are considered as markers of neuroectoderm origin in tumors, whereas fucosyl-GM1 is expressed
S. Groux-Degroote, P. Delannoy
semanticscholar   +1 more source

Glucosylceramide and galactosylceramide, small glycosphingolipids with significant impact on health and disease

Glycobiology, 2021
Numerous clinical observations and exploitation of cellular and animal models indicate that glucosylceramide (GlcCer) and galactosylceramide (GalCer) are involved in many physiological and pathological phenomena.
Safoura Reza, M. Ugorski, J. Suchański
semanticscholar   +1 more source

The repertoire of glycosphingolipids recognized by Vibrio cholerae. [PDF]

PLoS ONE, 2013
The binding of cholera toxin to the ganglioside GM1 as the initial step in the process leading to diarrhea is nowadays textbook knowledge. In contrast, the knowledge about the mechanisms for attachment of Vibrio cholerae bacterial cells to the intestinal
John Benktander, Jonas Ångström, Hasse Karlsson, Omid Teymournejad, Sara Lindén, Michael Lebens, Susann Teneberg   +6 more
doaj   +1 more source

Protein Recognition of Glycosphingolipids in Membranes: Mechanistic and Quantitative Insights. [PDF]

Anal Chem
Nguyen L, Han L, Kitova EN, Li J, Cheung NV, Ng KKS, Klassen JS.   +6 more
europepmc   +3 more sources

Glycosphingolipids Recognized by Acinetobacter baumannii

Microorganisms, 2020
Acinetobacter baumannii is an opportunistic bacterial pathogen associated with hospital-acquired infections, including pneumonia, meningitis, bacteremia, urinary tract infection, and wound infections.
Miralda Madar Johansson, Mehjar Azzouz, Beatrice Häggendal, Karin Säljö, Henri Malmi, Anton Zavialov, Susann Teneberg   +6 more
doaj   +1 more source