Results 11 to 20 of about 36,633 (265)
Glycosphingolipids in human parasites
FEBS Open Bio, 2023 Glycosphingolipids (GSLs) are comprised of glycans (oligosaccharides) linked to a lipid containing a sphingosine moiety. They are major membrane components in cells of most animals, and importantly, they also occur in parasitic protozoans and worms that ...
Richard D. Cummings
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Glycosphingolipids: synthesis and functions [PDF]
FEBS Journal, 2013 Glycosphingolipids (GSLs) comprise a heterogeneous group of membrane lipids formed by a ceramide backbone covalently linked to a glycan moiety. Hundreds of different glycans can be linked to tens of different ceramide molecules, giving rise to an astonishing variety of structurally different compounds, each of which has the potential for a specific ...
G. D’Angelo +3 more
semanticscholar +3 more sources
International Journal of Molecular Sciences, 2020 Glycosphingolipids (GSLs) are a specialized class of membrane lipids composed of a ceramide backbone and a carbohydrate-rich head group. GSLs populate lipid rafts of the cell membrane of eukaryotic cells, and serve important cellular functions including ...
Alex E. Ryckman +2 more
semanticscholar +1 more source
Lyso-glycosphingolipids: presence and consequences
Essays in Biochemistry, 2020 Lyso-glycosphingolipids are generated in excess in glycosphingolipid storage disorders. In the course of these pathologies glycosylated sphingolipid species accumulate within lysosomes due to flaws in the respective lipid degrading machinery. Deacylation
M. van Eijk +3 more
semanticscholar +1 more source
Targeting glycosphingolipids for cancer immunotherapy
FEBS Letters, 2020 Aberrant expression of glycosphingolipids (GSLs) is a unique feature of cancer and stromal cells in tumor microenvironments. Although the impact of GSLs on tumor progression remains largely unclear, anticancer immunotherapies directed against GSLs are ...
John Yu +4 more
semanticscholar +1 more source
Porcine intestinal glycosphingolipids recognized by F6-fimbriated enterotoxigenic Escherichia coli [PDF]
, 2014 One important virulence factor of enterotoxigenic Escherichia coli is their ability to adhere via fimbrial adhesins to specific receptors located on the intestinal mucosa. Here, the potential glycosphingolipid receptors of enterotoxigenic F6-fimbriated E.
Benktander, John +4 more
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Characterization of glycosphingolipids by direct inlet chemical ionization mass spectrometry
Journal of Lipid Research, 1980 Permethylated derivatives of cerebrosides and ceramide di-, tri-, tetra-, and penta-hexosides were analyzed by the direct inlet ammonia chemical ionization (CI) mass spectrometry. In the CI mass spectra, the fragment ions produced by the loss of methanol
T Ariga +4 more
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Glycosphingolipid Functions [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 The combination of carbohydrate and lipid generates unusual molecules in which the two distinctive halves of the glycoconjugate influence the function of each other. Membrane glycolipids can act as primary receptors for carbohydrate binding proteins to mediate transmembrane signaling despite restriction to the outer bilayer leaflet.
openaire +3 more sources
Micellar properties of glycosphingolipids in aqueous media.
Journal of Lipid Research, 1984 The aggregation properties of neutral glycosphingolipids and gangliosides were investigated by ultracentrifugal sedimentation and gel permeation chromatography. Initially, glycosphingolipids in buffer formed high molecular aggregates.
B Ulrich-Bott, H Wiegandt
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Immune Response Modulation by Tumor-Secreted Glycosphingolipids [PDF]
, 2014 Although originally considered merely structural components of cellular membranes, glycosphingolipids (GSL) arenow recognized as having critical effects on cellular physiology, including proliferation, differentiation, viraltransformation and ontogenesis.
Cely, Ingrid +3 more
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