Results 121 to 130 of about 52,375 (251)
The FEBS Journal, EarlyView.The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs +7 more
wiley +1 more source
Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations. [PDF]
, 2019 Loss-of-function mutations in progranulin (GRN) are a major autosomal dominant cause of frontotemporal dementia. Most pathogenic GRN mutations result in progranulin haploinsufficiency, which is thought to cause frontotemporal dementia in GRN mutation ...
Arrant, Andrew E +12 more
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The FEBS Journal, EarlyView.Here, we report the role of extracellular vesicles (EVs) released from melanoma cells constitutively expressing MHC class II in the regulation of immune cell functions and melanoma metastasis. In particular, we observed an increased localization of HLA‐DRα, CAM receptors, PD‐L1, and STAT3 signaling proteins in the EVs.
Francesca Costantini +4 more
wiley +1 more source
Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health
The FEBS Journal, EarlyView.Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin +2 more
wiley +1 more source
Clinical Ophthalmology, 2014 Yayoi Otsu, Masato Matsuoka, Kayako Matsuyama, Tetsuya Nishimura Department of Ophthalmology, Kansai Medical University, Takii Hospital, Osaka, Japan Background: The purpose of this study was to determine the clinical features of patients with type 2 ...
Otsu Y +3 more
doaj
TNF-α and Microalbuminuria in Patients with Type 2 Diabetes Mellitus
Journal of Diabetes Research, 2014 Aim. Recent evidence suggests that chronic subclinical inflammation plays a key role in the pathogenesis and progression of diabetic nephropathy.
I.-Th. Lampropoulou +5 more
doaj +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Iridoids constitute a prominent class of plant‐specialised metabolites, with carbocyclic iridoids (e.g., geniposide) and secoiridoids (e.g., loganin) diverging early in their biosynthetic pathways. This divergence is marked by substrate‐specific carboxyl methyltransferases—GjGAMT and CrLAMT—that catalyse the decisive methylation step in ...
Li Li +7 more
wiley +1 more source
Related factor analysis of anemia in patients with type 2 diabetic kidney disease
Linchuang shenzangbing zazhi, 2021 Objective To explore the related factors of anemia in patients with type 2 diabetic kidney disease（DKD）.Methods In this retrospective study, 334 patients with a clinical diagnosis of type 2 DKD were recruited and divided into anemia and non-anemia groups.
Zhang Jing +3 more
doaj
Effect of Slc35b4 knockdown on total and O-glycosylated cellular proteins in HepG2 cell line. (c2012) [PDF]
, 2012 Diabetes is considered a Non-Communicable Disease (NCD). Type II diabetes is caused by the lack of insulin production from liver beta cells in the aftermath of insulin resistance.
Antonios, Gregory
core
Plant Biotechnology Journal, EarlyView.ABSTRACT Mentha spicata L. (spearmint) is a high‐value aromatic and medicinal species, whose productivity is strongly affected by water deficit. Nevertheless, the molecular mechanisms underlying drought acclimation in this mint remain largely unexplored. Thus, here, we investigated the microRNA‐mediated regulatory processes triggered in M.
Alessia D'Agostino +7 more
wiley +1 more source