Results 131 to 140 of about 52,375 (251)

The serum uric acid to creatinine ratio as a diagnostic biomarker for normoalbuminuric diabetic kidney disease

Frontiers in Medicine
BackgroundTo evaluate the potential of the serum uric acid to serum creatinine ratio (SUA/SCr) as a diagnostic biomarker for normoalbuminuric diabetic kidney disease (NADKD).MethodsWe retrospectively analyzed demographic and biochemical data from 3,101 ...
Haoran Mu, Qilun Zhang, Wenyao Huang, Qiang Pan, Yan Zhang, Yanyan Lu, Zhangxiang Zhu, Xu Jiang, Guojuan Wang, Mao Zheng, Li Chen   +10 more
doaj   +1 more source

Alleviation of photoaging‐associated MMP upregulation, prostanoid biosynthesis, and cell cycle arrest with titanium dioxide, zinc oxide, and inorganic‐only (ZnO + TiO2) sunscreens

Photochemistry and Photobiology, EarlyView.
Inorganic sunscreens containing the UV filters titanium dioxide (TiO2) and/or zinc oxide (ZnO) alleviated various biomarkers of photoaging in human dermal fibroblasts, at a gene and protein level. The study provides novel insights that observe the impact of inorganic photoprotection through the molecular biology of skin.
Neil Dominic T. Pangilinan, Mohammad Shalbaf, Aline Souza, Bhaven Chavan, Mark A. Birch‐Machin   +4 more
wiley   +1 more source

Triglyceride-glucose index: a surrogate marker of homeostasis model assessment of insulin resistance to predict diabetic nephropathy

Journal of the Pakistan Medical Association
Objectives: To determine the association of triglyceride-glucose index with homeostasis model assessment of insulin resistance in type 2 diabetes mellitus patients, and to determine the association of triglyceride-glucose index with urinary albumin-to ...
Sania Khan, Shazia Qayyum, Muhammad Nadim Akbar Khan   +2 more
doaj   +1 more source

Glycosylation of the murine cardiac channel TRPM4 is altered by the pathogenic p.I376T variant

Experimental Physiology, EarlyView.
Abstract TRPM4 is a calcium‐activated, voltage‐modulated, non‐selective cation channel expressed in various tissues, including the heart. In 2016, we reported on a large French family with progressive heart block type I carrying the variant TRPM4 p.I376T.
Sabrina Guichard, Emanuele di Lorenzo, Dominic Schneiter, Maria Essers, Prakash Arullampalam, Jean‐Sébastien Rougier, Hugues Abriel   +6 more
wiley   +1 more source

Lupin (Lupinus angustifolius) as a Protein‐Rich Emerging Crop Adapted to Uruguay: Nutritional and Functional Potential

Sustainable Food Proteins, Volume 4, Issue 2, June 2026.
Characterization of Lupinus angustifolius cultivated in Uruguay. The figure summarizes the experimental workflow applied to six Lupinus angustifolius samples cultivated in Uruguay. After sample preparation, different analytical approaches were performed: Proximate composition determination of moisture, ash, crude protein, and crude fat by standard AOAC
Matías Rodríguez‐Elhordoy, Jessica Báez, Victoria Olt, Adriana Maite Fernández‐Fernández, Natalia Martínez, Bruno Irigaray, Javier Silva, Mariela Pistón, Daniel Vázquez, Alejandra Medrano   +9 more
wiley   +1 more source

The development of type 2 diabetes amongst sibling pairs in the South‐South region of Nigeria: The effect of genetics, environment and lifestyle

Diabetic Medicine, Volume 43, Issue 6, June 2026.
Abstract Introduction Type 2 diabetes is a complex condition with a multifactorial pathogenesis. The pathogenesis is considered to be polygenic due to complex interactions between genetic/epigenetic and environmental factors. The aim of this study is to determine the genetic, environmental and lifestyle factors associated with the development of type 2
Sunny Chinenye, Ibi Erekosima, Adrian H. Heald, Gesiye Bozimo, Simon G. Anderson, Samuel Seidu, Kariba Akhidue, Adaeze Ugwu, Chioma Unachukwu, Ibitrokoemi Korubo, Kingsley Chukwuemeka Patrick‐Iwuanyanwu, Victoria Gomba, Uwoma Batubo, Victoria Akanatei, Victor Ken‐Uba, Iyeopu Siminialayi, Sokiprim Akoko, Justin Ideozu, Hamilton Opurum   +18 more
wiley   +1 more source

Fibrotic NASH Index (FNI) Is Associated with Long‐Term Mortality in Individuals with Type 2 Diabetes and MASLD

Liver International, Volume 46, Issue 6, June 2026.
ABSTRACT Background and Aim Metabolic dysfunction‐associated steatotic liver disease (MASLD) frequently coexists with type 2 diabetes (T2D) and increases cardiovascular disease (CVD) risk, with hepatic fibrosis being the main determinant of mortality.
Ilaria Barchetta, Flavia Agata Cimini, Sara Dule, Giulia Passarella, Alessandro Oldani, Maria Neve Hirsch, Marta Cirelli, Marta Alfano, Maria Gisella Cavallo   +8 more
wiley   +1 more source

CD30 Expression in Neoplastic Mast Cells and the Presence of CD30+, CD3+, and PAX‐5+ Tumour‐Infiltrating Lymphocytes as Prognostic Markers in Canine Cutaneous Mast Cell Tumours

Veterinary and Comparative Oncology, Volume 24, Issue 2, Page 341-352, June 2026.
ABSTRACT Canine cutaneous mast cell tumour (MCT) is the most common skin neoplasm in dogs, with histopathology serving as both the diagnostic and primary prognostic tool. However, identifying reliable biomarkers is essential for improving clinical decision‐making.
Fernanda Ramalho Ramos, Janayna Maria Parente Serafim, Bethânia Almeida Gouveia, Pedro Luiz Porfirio Xavier, Juliano Rodrigues Sangalli, Heidge Fukumasu, Ricardo de Francisco Strefezzi   +6 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, Volume 16, Issue 5, Page 944-965, May 2026.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Promotion of DFU Wound Healing via BRG1–COL16A1 Axis in Fibroblasts

Advanced Science, Volume 13, Issue 26, 8 May 2026.
In normal wound healing, transcription factor BRG1 is upregulated and binds the COL16A1 promoter to enhance its expression, promoting fibroblast proliferation, migration, contraction, extracellular matrix deposition, and granulation tissue formation, thus accelerating wound closure.
Penghui Wang, Jiaming Sun, Ying Wang, Bichen Ren, Yuxin Liu, Yunhan Liu, Liang Chen, Lu Yu, Tao Dai, Li Yu, Zhihui Dong   +10 more
wiley   +1 more source