Blockade of interleukin-6 (IL-6) signaling in dedifferentiated liposarcoma (DDLPS) decreases mouse double minute 2 (MDM2) oncogenicity via alternative splicing. [PDF]
PLoS ONEEffective therapies for retroperitoneal (RP) dedifferentiated liposarcoma (DDLPS) remain unavailable. Loco-regional recurrence occurs in >80% of cases; 5-year disease-specific survival is only 20%. DDLPS is especially prevalent in the retroperitoneum and
Abeba Zewdu +15 more
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The Role of gp130 Cytokines in Tuberculosis [PDF]
Cells, 2020 Protective immune responses to Mycobacterium tuberculosis (Mtb) infection substantially depend on a delicate balance within cytokine networks. Thus, immunosuppressive therapy by cytokine blockers, as successfully used in the management of various chronic
Kristina Ritter +2 more
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Receptor engineering constitutes feedback control and robustness of IL-23R signaling and highlights importance of intracellular cytokine receptor signaling motifs [PDF]
Cell Communication and SignalingBackground In the current medical landscape, synthetic cytokine receptors have emerged as a pivotal component in the development of novel therapeutic interventions.
Leorina Kashtanjeva +9 more
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Context dependent role of miR-486 promoting neuroregeneration of primary sensory neurons downstream of interleukin-6 signal transducer [PDF]
Molecular Therapy: Nucleic AcidsThe pro-inflammatory cytokine interleukin-6 (IL-6) via its IL-6 signal transducer (IL6ST/gp130) plays an important role in neuronal survival, neuro-regeneration, and pathological pain.
Theodora Kalpachidou +11 more
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GP130 Antagonism Enhances Porcine RV Function. [PDF]
Circ ResBACKGROUND: Right ventricular (RV) dysfunction is a risk factor for death in multiple cardiovascular diseases, but RV-enhancing therapies are lacking. Inhibition of GP130 (glycoprotein-130) signaling with the small molecule SC144 improves RV function in rodent RV dysfunction via anti-inflammatory and metabolic ...
Mendelson JB +12 more
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Fine mapping of heterozygous IL6ST nonsense variants underlying autosomal dominant hyper-IgE syndrome [PDF]
JCI InsightLoss-of-function (LOF) variants in IL6ST, encoding GP130, can cause hyper-IgE syndrome (HIES). Monoallelic LOF variants in IL6ST lead to HIES when located in the intracellular domain downstream of box 1/2 and upstream of the STAT3 phosphorylation sites ...
Kosuke Ashihara +20 more
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IL-6 Signaling in Immunopathology: From Basic Biology to Selective Therapeutic Intervention [PDF]
ImmunoTargets and TherapyTim Schumertl, Juliane Lokau, Christoph Garbers Institute of Clinical Biochemistry, Hannover Medical School, Hannover, 30625, GermanyCorrespondence: Christoph Garbers, Institute of Clinical Biochemistry, Hannover Medical School, Carl-Neuberg-Strasse 1 ...
Schumertl T, Lokau J, Garbers C
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Differential role of gp130-dependent STAT and Ras signalling for haematopoiesis following bone-marrow transplantation. [PDF]
PLoS ONE, 2012 INTRODUCTION: Bone marrow transplantation (BMT) is a complex process regulated by different cytokines and growth factors. The pleiotropic cytokine IL-6 (Interleukin-6) and related cytokines of the same family acting on the common signal transducer gp130 ...
Daniela C Kroy +8 more
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Scientific Reports, 2023 Leukemia inhibitory factor (LIF) receptor, an interleukin 6 cytokine family signal transducer (Il6st, also known as Gp130) that is expressed in the uterine epithelium and stroma, has been recognized to play an essential role in embryo implantation ...
Takafumi Namiki +9 more
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Communications Biology, 2023 All except one cytokine of the Interleukin (IL-)6 family share glycoprotein (gp) 130 as the common β receptor chain. Whereas Interleukin (IL-)11 signal via the non-signaling IL-11 receptor (IL-11R) and gp130 homodimers, leukemia inhibitory factor (LIF ...
Puyan Rafii +11 more
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