Results 131 to 140 of about 14,390 (160)
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gp130 blockade to NOD off Crohn’s disease
Trends in Immunology, 2021In a recent publication, Nayar et al. uncover specific inflammatory cell populations associated with Crohn's disease (CD) pathogenesis, and a gp130-STAT3 signaling axis linked to disease in anti-TNF antibody treatment-refractory patients. Therefore, gp130 blockade might represent a potential CD therapy approach, perhaps in conjunction with existing ...
Tapas, Mukherjee, Dana J, Philpott
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Conditional gp130 deficient mouse mutants
Seminars in Cell & Developmental Biology, 2008The common cytokine receptor chain, gp130, controls the activity of a group of cytokines, namely, IL-6, IL-11, IL-27, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine (CLC) and neuropoietin (NPN).
Fasnacht, Nicolas, Müller, Werner
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Interleukin‐11: A gp130 Cytokine
Annals of the New York Academy of Sciences, 1998ABSTRACT: Interleukin (IL)‐11 is a member of the gp130 family of cytokines. Comparison of IL‐11 with another gp130 family member, IL‐6, indicates that these two cytokines share many overlapping signal transduction mechanisms. However, unlike IL‐6, treatment of patients with a recombinant human form of IL‐11 (rhIL‐11) does not increase body temperature,
William L, Trepicchio, Andrew J, Dorner
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gp130-DEPENDENT SIGNALLING PATHWAY IS NOT ENHANCED IN gp130 TRANSGENIC HEART AFTER LIF STIMULATION
Cytokine, 2000Activation of gp130 transduces a hypertrophic signal in the heart, but it is not clear whether signalling through gp130 is enhanced when gp130 is overexpressed in vivo. We generated gp130 transgenic mice (TG) and examined the activation of signalling pathways downstream of gp130 in the hearts.
E, Tone +7 more
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Receptor recognition by gp130 cytokines
Biochemical Society Transactions, 2000Cytokines of the gp130 family exert their diverse biological effects by formation of stable high affinity transmembrane receptor complexes that are characterized by the presence of the shared transmembrane signalling receptor gp130. Different gp130 ligands form signalling complexes that vary in both composition and stoichiometry.
J. K. Heath +3 more
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GP130 in Human Myeloma/Plasmacytoma
1995Interleukin 6 (IL-6) is a potent growth factor for human myeloma/plasmacytoma cells (Kawano et al. 1988, Klein et al. 1989) The evidences that 1) myeloma cells produce IL-6 and express IL-6 receptor (IL-6R), 2) IL-6 augments the in vitro growth of myeloma cells, 3) anti-IL-6 antibody (Ab) or anti-IL-6R Ab inhibits their growth (Klein et al.
Y, Tani +5 more
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gp130 CYTOKINE FAMILY AND BONE CELLS
Cytokine, 2000Bone tissue is continually being remodelled according to physiological circumstances. Two main cell populations (osteoblasts and osteoclasts) are involved in this process, and cellular activities (including cell differentiation) are modulated by hormones, cytokines and growth factors.
D, Heymann, A V, Rousselle
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European Journal of Immunology, 1997
AbstractSix cytokines of the interleukin (IL)‐6 family involved in various inflammatory or tumoral diseases share the same gp130 signal transducer chain. We made a panel of anti‐gp130 monoclonal antibodies (mAb) to study the structure and function of the gp130 molecule. These mAb recognized different epitopes of the gp130 that we called A to J. Most of
P, Autissier +3 more
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AbstractSix cytokines of the interleukin (IL)‐6 family involved in various inflammatory or tumoral diseases share the same gp130 signal transducer chain. We made a panel of anti‐gp130 monoclonal antibodies (mAb) to study the structure and function of the gp130 molecule. These mAb recognized different epitopes of the gp130 that we called A to J. Most of
P, Autissier +3 more
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2000
Cytokines are secreted multifunctional proteins, exerting local autocrine and paracrine, as well as sys- temic endocrine actions. Although originally thought to be derived from hematopoietic and immune cells, these molecules are secreted by a variety of different cell types and affect multiple target cells.
Christoph J. Auernhammer, Shlomo Melmed
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Cytokines are secreted multifunctional proteins, exerting local autocrine and paracrine, as well as sys- temic endocrine actions. Although originally thought to be derived from hematopoietic and immune cells, these molecules are secreted by a variety of different cell types and affect multiple target cells.
Christoph J. Auernhammer, Shlomo Melmed
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The Cytokine Receptor gp130: Faithfully Promiscuous
Science Signaling, 2003Diverse cytokines can signal through receptor complexes containing the gp130 subunit. These cytokines, which include interleukin (IL)-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), and CLC (cardiotrophin-like cytokine), are implicated in inflammatory and immune responses ...
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