Results 11 to 20 of about 14,390 (160)

The Alzheimer’s disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130

Molecular Neurodegeneration, 2023
Background The protease BACE1 is a major drug target for Alzheimer’s disease, but chronic BACE1 inhibition is associated with non-progressive cognitive worsening that may be caused by modulation of unknown physiological BACE1 substrates.
Stephan A. Müller, Merav D. Shmueli, Xiao Feng, Johanna Tüshaus, Neele Schumacher, Ryan Clark, Brad E. Smith, An Chi, Stefan Rose-John, Matthew E. Kennedy, Stefan F. Lichtenthaler   +10 more
doaj   +1 more source

The role of glycoprotein 130 family of cytokines in fetal rat lung development. [PDF]

PLoS ONE, 2013
The glycoprotein 130 (gp130) dependent family of cytokines comprises interleukin-6 (IL-6), IL-11, leukemia inhibitory factor (LIF), cardiotrophin-like cytokine (CLC), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1) and oncostatin M (OSM ...
Cristina Nogueira-Silva, Paulina Piairo, Emanuel Carvalho-Dias, Carla Veiga, Rute S Moura, Jorge Correia-Pinto   +5 more
doaj   +1 more source

Effect of (−)-Epigallocatechin Gallate on Activation of JAK/STAT Signaling Pathway by Staphylococcal Enterotoxin A

Toxins, 2021
Staphylococcal enterotoxin A (SEA), which is a superantigen toxin protein, binds to cytokine receptor gp130. Gp130 activates intracellular signaling pathways, including the Janus kinase/signal transducers and activators of transcription (JAK/STAT ...
Yuko Shimamura, Rina Noaki, Ami Kurokawa, Mio Utsumi, Chikako Hirai, Toshiyuki Kan, Shuichi Masuda   +6 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

gp130 Activates Mitochondrial Dynamics for Hepatocyte Survival in a Model of Steatohepatitis

Biomedicines, 2023
Obesity is the main cause of metabolic complications. Fatty liver infiltration is a companion of obesity. NAFLD is associated with impaired energy metabolism with an excess of nutrients.
Daria Shunkina, Anastasia Dakhnevich, Egor Shunkin, Olga Khaziakhmatova, Valeria Shupletsova, Maria Vulf, Alexandra Komar, Elena Kirienkova, Larisa Litvinova   +8 more
doaj   +1 more source

Transactivation of gp130 in Myeloma Cells [PDF]

The Journal of Immunology, 2003
Abstract Receptor transactivation, i.e., interaction between unrelated receptor systems, is a growing theme in cytokine and growth factor signaling. In this study we reveal for the first time the ability of IFN-α to transactivate gp130 in myeloma cells. An epidermal growth factor receptor/gp130 chimeric receptor previously shown by us to
Jena D, French, Denise K, Walters, Diane F, Jelinek   +2 more
openaire   +2 more sources

Are physiological oscillations physiological?

The Journal of Physiology, EarlyView., 2023
Abstract figure legend Mechanisms and functions of physiological oscillations. Abstract Despite widespread and striking examples of physiological oscillations, their functional role is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen questions about its oscillatory function.
Lingyun (Ivy) Xiong, Alan Garfinkel
wiley   +1 more source

Gp130-dependent signaling in the podocyte [PDF]

American Journal of Physiology-Renal Physiology, 2014
Renal inflammation, in particular glomerular, is often characterized by increased IL-6 levels. The in vivo relevance of IL-6 signaling in glomerular podocytes, which play central roles in most glomerular diseases, is unknown. Here, we show that in normal mice, podocytes express gp130, the common signal-transducing receptor subunit of the IL-6 family of
Yoshikuni, Nagayama, Gerald S, Braun, Christina M, Jakobs, Yuichi, Maruta, Claudia R, van Roeyen, Barbara M, Klinkhammer, Peter, Boor, Luigi, Villa, Ute, Raffetseder, Christian, Trautwein, Dieter, Görtz, Gerhard, Müller-Newen, Tammo, Ostendorf, Jürgen, Floege   +13 more
openaire   +2 more sources

In vitro and in vivo pharmacokinetic characterization of LMT-28 as a novel small molecular interleukin-6 inhibitor [PDF]

Asian-Australasian Journal of Animal Sciences, 2020
Objective Interleukin-6 (IL-6) is a T cell-derived B cell stimulating factor which plays an important role in inflammatory diseases. In this study, the pharmacokinetic properties of LMT-28 including physicochemical property, in vitro liver microsomal ...
Sung-Hoon Ahn, Tae-Hwe Heo, Hyun-Sik Jun, Yongseok Choi   +3 more
doaj   +1 more source

Repositioning Bazedoxifene as a novel IL-6/GP130 signaling antagonist for human rhabdomyosarcoma therapy. [PDF]

PLoS ONE, 2017
Interleukins-6 (IL-6)/GP130 signaling pathway represents a promising target for cancer therapy due to its critical role in survival and progression of multiple types of cancer.
Hui Xiao, Hemant Kumar Bid, Xiang Chen, Xiaojuan Wu, Jia Wei, Yang Bian, Chengguang Zhao, Huameng Li, Chenglong Li, Jiayuh Lin   +9 more
doaj   +1 more source