Results 61 to 70 of about 14,390 (160)

Interleukin-6 and insulin-like growth factor-1 synergistically promote the progression of NSCLC

Autoimmunity, 2018
The signaling pathways of interleukin-6 (IL-6) and insulin-like growth factor 1 (IGF-1) play an important role in the progression of lung cancer, and this study aimed to explore whether they can synergistically promote the progression of non-small cell ...
Hexiao Tang, Yuquan Bai, Gaofeng Pan, Xianguo Wang, Yanhong Wei, Zetian Yang, Jinping Zhao   +6 more
doaj   +1 more source

IL-6 Is Not Absolutely Essential for the Development of a TH17 Immune Response after an Aerosol Infection with Mycobacterium tuberculosis H37rv

Cells, 2020
Anti-inflammatory treatment of chronic inflammatory diseases often increases susceptibility to infectious diseases such as tuberculosis (TB). Since numerous chronic inflammatory and autoimmune diseases are mediated by interleukin (IL)-6-induced T helper (
Kristina Ritter, Jan Christian Sodenkamp, Alexandra Hölscher, Jochen Behrends, Christoph Hölscher   +4 more
doaj   +1 more source

GP130 activation induces myeloma and collaborates with MYC [PDF]

Journal of Clinical Investigation, 2014
Multiple myeloma (MM) is a plasma cell neoplasm that results from clonal expansion of an Ig-secreting terminally differentiated B cell. Advanced MM is characterized by tissue damage that involves bone, kidney, and other organs and is typically associated with recurrent genetic abnormalities.
Dechow, Tobias, Steidle, Sabine, Götze, Katharina S., Rudelius, Martina, Behnke, Kerstin, Pechloff, Konstanze, Kratzat, Susanne, Bullinger, Lars, Fend, Falko, Soberon, Valeria, Mitova, Nadya, Li, Zhoulei, Thaler, Markus, Bauer, Jan, Pietschmann, Elke, Albers, Corinna, Grundler, Rebekka, Schmidt-Supprian, Marc, Ruland, Jürgen, Peschel, Christian, Duyster, Justus, Rose-John, Stefan, Bassermann, Florian, Keller, Ulrich Bernd   +23 more
openaire   +3 more sources

Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?

Arthritis &Rheumatology, Volume 78, Issue 3, Page 548-557, March 2026.
Objective Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify noninvasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in ...
Valentina Querin, Leonardo Palazzo, Agnes B. Fogo, Mark Haas, David R. W. Jayne, Liz Lightstone, Brad H. Rovin, Surya V. Seshan, Augusto Vaglio, Ioannis Parodis, Ingeborg M. Bajema, for the Lupus Nephritis Classification Steering Committee   +11 more
wiley   +1 more source

Inhibition of IL‐6/STAT3 Signaling by N‐Trans‐Hibiscusamide and Its Derivative in a Mouse Model of Collagen‐Induced Arthritis

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
The IL‐6/STAT3 axis is crucial in rheumatoid arthritis (RA) via Th17 differentiation. The IL‐6/STAT3 signaling pathway is downregulated as a result of the inhibition of IL‐6 and IL‐6R binding by NHA and NAD. NHA and NAD decrease the Th17 differentiation, which lessens the severity of CIA.
Hyung Jin Lim, Seon Gyeong Bak, Jaehoon Bae, Nisansala Chandimali, Eun Jae Park, Seung Woong Lee, Mingyeong Kim, Sang‐Hoon Lee, Yeong‐Seon Won, Sun Hee Cheong, Seung‐Jae Lee   +10 more
wiley   +1 more source

Strategies for Monitoring Serum Protein Degradation With an Antibody Array‐Based Technology

Journal of Clinical Laboratory Analysis, Volume 40, Issue 5, March 2026.
This study analyzed the stability of 480 proteins in human serum samples collected from 10 healthy donors and incubated at room temperature for 0–48 h. Antibody array profiling revealed significant time‐dependent degradation of 201 proteins. Subsequent physicochemical and functional enrichment analyses demonstrated that the degraded proteins were ...
Yanlin Wang, Min Lang, Wei Huang, Siwei Zhu, Yingqing Mao, Shuhong Luo, Hua Dong, Ruo‐Pan Huang   +7 more
wiley   +1 more source

Ironing Out the Mechanism of gp130 Signaling

Pharmacological Reviews
gp130 functions as a shared signal-transducing subunit not only for interleukin (IL)-6 but also for eight other human cytokine receptor complexes. The IL-6 signaling pathway mediated through gp130 encompasses classical, trans, or cluster signaling, intricately regulated by a diverse array of modulators affecting IL-6, its receptor, and gp130. Currently,
Essam Eldin A. Osman, Nouri Neamati
openaire   +2 more sources

Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Cellular senescence shapes tumor progression through both antitumor and protumor mechanisms. Senescence triggered by telomere shortening restricts malignant transformation and limits tumor cell proliferation, while the senescence‐associated secretory phenotype (SASP) secretion enhances antitumor immunity by activating cytotoxic T cells.
Huajie Mao, Wanning Liu, Yuanyuan Su, Yuxuan Ma, Xiaodi Zhao, Yuanyuan Lu   +5 more
wiley   +1 more source

Navigating the cholesterol maze: Key insights on use of statins in neurodegenerative disorders

Neuroprotection, Volume 4, Issue 1, Page 30-47, March 2026.
The graphical abstract encapsulates the dual neuroprotective mechanisms of statins in neurodegenerative diseases, highlighting both cholesterol‐dependent and cholesterol‐independent pathways. By inhibiting 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase, statins reduce cholesterol synthesis, leading to altered lipid raft structures that ...
Jun Han Kuan, Roshan S. Raghavan, Dawn Li Wei Koh, Wing Yeng Tan, Igor Iezhitsa, Renu Agarwal   +5 more
wiley   +1 more source

Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity

Journal of Lipid Research, 2017
Autotaxin (ATX), which is highly expressed and secreted by adipocytes, functions as the key enzyme to generate lysophosphatidic acid (LPA) from lysophosphatidylcholine. Adipose tissue is the main source of circulating ATX that modulates plasma LPA levels.
Shuhong Sun, Ran Wang, Jianwen Song, Ming Guan, Na Li, Xiaotian Zhang, Zhenwen Zhao, Junjie Zhang   +7 more
doaj   +1 more source