Results 1 to 10 of about 40,571 (376)

Pharmacological activation of GPX4 ameliorates doxorubicin-induced cardiomyopathy

Redox Biology
Due to the cardiotoxicity of doxorubicin (DOX), its clinical application is limited. Lipid peroxidation caused by excessive ferrous iron is believed to be a key molecular mechanism of DOX-induced cardiomyopathy (DIC). Dexrazoxane (DXZ), an iron chelator, is the only drug approved by the FDA for reducing DIC, but it has many side effects and cannot be ...
Chuying Huang, Yishan Guo, Tuo Li, Guogen Sun, Jinru Yang, Yuqi Wang, Ying Xiang, Li Wang, Min Jin, Jiao Li, Yong Zhou, Bing Han, Rui Huang, Jiao Qiu, Yong Hui Tan, Jiaxing Hu, Yumiao Wei, Bo Wu, Yong Mao, Lingshan Lei, Xiusheng Song, Shuijie Li, Yongsheng Wang, Tao Zhang   +23 more
semanticscholar   +5 more sources

GPX4 in cell death, autophagy, and disease

Autophagy, 2023
Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX (phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use of glutathione as a reducing agent in scavenging lipid peroxidation products.
Yangchun Xie, Rui Kang, D. Klionsky, D. Tang   +3 more
semanticscholar   +3 more sources

Regulation of Ferroptotic Cancer Cell Death by GPX4 [PDF]

Cell, 2014
Ferroptosis is a form of nonapoptotic cell death for which key regulators remain unknown. We sought a common mediator for the lethality of 12 ferroptosis-inducing small molecules. We used targeted metabolomic profiling to discover that depletion of glutathione causes inactivation of glutathione peroxidases (GPXs) in response to one class of compounds ...
W. Yang, Rohitha Sriramaratnam, Matthew E. Welsch, K. Shimada, R. Skouta, V. Viswanathan, J. Cheah, P. Clemons, Alykhan F. Shamji, C. Clish, L. Brown, A. Girotti, V. Cornish, S. Schreiber, B. Stockwell   +14 more
semanticscholar   +3 more sources

Copper-dependent autophagic degradation of GPX4 drives ferroptosis

Autophagy, 2023
Ferroptosis is a type of iron-dependent regulated cell death characterized by unrestricted lipid peroxidation and membrane damage. Although GPX4 (glutathione peroxidase 4) plays a master role in blocking ferroptosis by eliminating phospholipid ...
Qian Xue, Ding Yan, Xi Chen, Xiaofen Li, Rui Kang, D. Klionsky, G. Kroemer, Xin Chen, D. Tang, Jinbao Liu   +9 more
semanticscholar   +3 more sources

GPX4, ferroptosis, and diseases.

Biomedicine & Pharmacotherapy
GPX4 (Glutathione peroxidase 4) serves as a crucial intracellular regulatory factor, participating in various physiological processes and playing a significant role in maintaining the redox homeostasis within the body. Ferroptosis, a form of iron-dependent non-apoptotic cell death, has gained considerable attention in recent years due to its ...
Wangzheqi Zhang, Yang Liu, Yan Liao, Chenglong Zhu, Zui Zou   +4 more
semanticscholar   +3 more sources

Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis

Nature Communications
S-palmitoylation is a reversible and widespread post-translational modification, but its role in the regulation of ferroptosis has been poorly understood. Here, we elucidate that GPX4, an essential regulator of ferroptosis, is reversibly palmitoylated on
Bin Huang, Hui Wang, Shuo Liu, Meng Hao, Dan Luo, Yi Zhou, Ying Huang, Yong Nian, Lei Zhang, Bo Chu, Chengqian Yin   +10 more
semanticscholar   +4 more sources

TFEB promotes Ginkgetin-induced ferroptosis via TRIM25 mediated GPX4 lysosomal degradation in EGFR wide-type lung adenocarcinoma

Theranostics
Rationale: TFEB activation is associated with prolonged survival in LUAD patients, suggesting potential benefits of TFEB agonists in LUAD treatment. In this study, we identify ginkgetin (GK), derived from Ginkgo folium, as a natural TFEB agonist, which ...
Haojie Wang, Linyinxue Dong, Lili Ding, Xudong Miao, Yuwen Zhang, Liping Zhao, Lihua Yu, Zhen-Rong Guan, Yaping Jiang, Xiaoqi Tang, Ya-Xin Yan, Jian-Shu Lou   +11 more
openalex   +2 more sources

Traditional Chinese Formula Xiaoyaosan Alleviates Depressive-Like Behavior in CUMS Mice by Regulating PEBP1-GPX4-Mediated Ferroptosis in the Hippocampus

Neuropsychiatric Disease and Treatment, 2021
Haiyan Jiao,1 Hongjun Yang,1 Zhiyi Yan,1 Jianbei Chen,1 Mengbai Xu,1 Youming Jiang,1 Yueyun Liu,1 Zhe Xue,1 Qingyu Ma,2 Xiaojuan Li,2 Jiaxu Chen1,2 1School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, People ...
Jiao H, Yang H, Yan Z, Chen J, Xu M, Jiang Y, Liu Y, Xue Z, Ma Q, Li X, Chen J   +10 more
doaj   +3 more sources

GPX4 overexpression does not alter atherosclerotic plaque development in ApoE knock-out mice [PDF]

Vascular Biology
Ferroptosis is a type of regulated necrosis that is associated with iron-dependent accumulation of lipid hydroperoxides. Given that iron deposition and lipid peroxidation initiate ferroptosis in atherosclerosis and contribute to further plaque ...
Isabelle Coornaert, Annelies Breynaert, Nina Hermans, Guido R Y De Meyer, Wim Martinet   +4 more
doaj   +2 more sources

GPX4-AUTAC induces ferroptosis in breast cancer by promoting the selective autophagic degradation of GPX4 mediated by TRAF6-p62

Cell Death & Differentiation
Emerging evidence indicates that activation of ferroptosis by inhibition of glutathione peroxidase 4 (GPX4) may be exploited as a therapeutic strategy to suppress tumor growth and progression. However, application of GPX4 inhibitors in cancer treatment is hampered by their poor selectivity, which results in unfavorable toxicity.
Rong Gong, Xiaoya Wan, Shi-long Jiang, Yidi Guan, Yizhi Li, Ting Jiang, Zonglin Chen, Changxin Zhong, Linhao He, Zhongyuan Xiang, Junya Yang, Biao Xu, Jinming Yang, Yan Cheng   +13 more
semanticscholar   +4 more sources