Contribution of ferroptosis and GPX4’s dual functions to osteoarthritis progression [PDF]
EBioMedicine, 2022 Summary: Background: Osteoarthritis (OA) is the most common joint disease and is the leading cause of chronic disability among older people. Chondrocyte death and extracellular matrix (ECM) degradation was involved in OA pathogenesis. Ferroptosis was an
Yu Miao +8 more
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Se improves GPX4 expression and SOD activity to alleviate heat-stress-induced ferroptosis-like death in goat mammary epithelial cells [PDF]
Animal Cells and Systems, 2021 Selenium (Se) is a vital element of life, which has an important impact on the growth, development, production performance and stress-tolerance of animals. However, it is not entirely clear that how exactly Se works during these processes.
Lu Liu +4 more
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Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. [PDF]
, 2017 Acquired drug resistance prevents cancer therapies from achieving stable and complete responses. Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer 'persister' cells.
Berens, Michael E +11 more
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Role of GPX4-Mediated Ferroptosis in the Sensitivity of Triple Negative Breast Cancer Cells to Gefitinib [PDF]
Frontiers in Oncology, 2020 Gefitinib resistance in triple negative breast cancer (TNBC) is a growing important concern. Glutathione peroxidase 4 (GPX4) is a main regulator of ferroptosis, which is pivotal for TNBC cell growth. We investigated GPX4-mediated ferroptosis in gefitinib
Xiang Song +3 more
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Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy [PDF]
Molecular Metabolism, 2015 Objective: Lipid peroxides and their reactive aldehyde derivatives (LPPs) have been linked to obesity-related pathologies, but whether they have a causal role has remained unclear.
Lalage A. Katunga +11 more
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HDAC3 aberration-incurred GPX4 suppression drives renal ferroptosis and AKI-CKD progression
Redox Biology, 2023 Acute kidney injury (AKI) progression to chronic kidney disease (CKD) represents a unique renal disease setting characterized by early renal cellular injury and regulated cell death, and later renal fibrosis, of which the critical role and nature of ...
Lijun Zhang +10 more
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The mechanism of irisin via Nrf2/GPX4 signaling pathway in alleviating lipopolysaccha-ride-induced acute lung injury in rats [PDF]
Yixue xinzhi zazhi, 2023 Objective To study the role of Nrf2/GPX4 signaling pathway in irisin alleviating lipopoly-saccharide (LPS)-induced acute lung injury in rats.Method Seventy-two healthy male SD rats were ran-domly divided into control group (C group), acute lung injury ...
Jing LUO +4 more
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Effects of nano-selenium and sodium selenite on SelP, GPx4 and SelW genes expression in testes of broiler breeder roosters [PDF]
Bulgarian Journal of Veterinary Medicine, 2020 Fertility is the main element affecting hatchability as an important indicator in breeder flocks’ per-formance. Roosters’ aging reduces their fertility.
H. Jafarzadeh +4 more
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European Journal of Histochemistry, 2022 Cellular senescence and ferroptosis are the two main, fine-tuned processes in tissue damage restraint; however, they can be overactivated in pathologies such as nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH), becoming ...
Antonella Vetuschi +6 more
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Wedelolactone attenuates cerebral ischemia-reperfusion injury by blocking GPX4-mediated ferroptosis [PDF]
Journal of Men's Health, 2023 Cerebral ischemia is currently the third leading cause of death worldwide. Among its complications, cerebral ischemia-reperfusion (I/R) is considered the most inevitable problem.
Huyin Yang, Dai Liu, Yanping Wang
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