Results 1 to 10 of about 5,253 (50)

Copper-dependent autophagic degradation of GPX4 drives ferroptosis

Autophagy, 2023
Ferroptosis is a type of iron-dependent regulated cell death characterized by unrestricted lipid peroxidation and membrane damage. Although GPX4 (glutathione peroxidase 4) plays a master role in blocking ferroptosis by eliminating phospholipid ...
Qian Xue, Ding Yan, Xi Chen, Xiaofen Li, Rui Kang, D. Klionsky, G. Kroemer, Xin Chen, D. Tang, Jinbao Liu   +9 more
semanticscholar   +1 more source

GPX4 in cell death, autophagy, and disease

Autophagy, 2023
Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX (phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use of glutathione as a reducing agent in scavenging lipid peroxidation products.
Yangchun Xie, Rui Kang, D. Klionsky, D. Tang   +3 more
semanticscholar   +1 more source

The CoQ oxidoreductase FSP1 acts in parallel to GPX4 to inhibit ferroptosis

Nature, 2019
Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation of lipids1,2. The glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid hydroperoxides into non-
K. Bersuker, Joseph M. Hendricks, Zhipeng Li, Leslie Magtanong, Breanna Ford, P. Tang, Melissa A. Roberts, Bingqi Tong, T. Maimone, R. Zoncu, M. Bassik, Daniel K. Nomura, S. Dixon, James A. Olzmann   +13 more
semanticscholar   +1 more source

Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer

Cell Death and Differentiation, 2022
The development of chemotherapy resistance is the most vital obstacle to clinical efficacy in gastric cancer (GC). The dysregulation of the Wnt/beta-catenin signaling pathway is critically associated with GC development and chemotherapy resistance ...
Yue Wang, Lixin Zheng, Wenjing Shang, Zongchen Yang, Tongyu Li, Fen Liu, Weimin Shao, Lin Lv, Li Chai, L. Qu, Qing Xu, J. Du, Xiuming Liang, Jiping Zeng, J. Jia   +14 more
semanticscholar   +1 more source

Polydopamine Nanoparticles Targeting Ferroptosis Mitigate Intervertebral Disc Degeneration Via Reactive Oxygen Species Depletion, Iron Ions Chelation, and GPX4 Ubiquitination Suppression

Advancement of science, 2023
Intervertebral disc degeneration (IVDD)‐induced lower back pain (LBP) is a common problem worldwide. The underlying mechanism is partially accredited to ferroptosis, based on sequencing analyses of IVDD patients from the gene expression omnibus (GEO ...
Xiao Yang, Yan Chen, Jiadong Guo, Jiaxin Li, Pu Zhang, H. Yang, KE Rong, Tangjun Zhou, Jingke Fu, Jie‐Zu Zhao   +9 more
semanticscholar   +1 more source

Mitophagy alleviates cisplatin-induced renal tubular epithelial cell ferroptosis through ROS/HO-1/GPX4 axis

International Journal on Biological Sciences, 2023
Cisplatin is widely recommended in combination for the treatment of tumors, thus inevitably increasing the incidence of cisplatin-induced acute kidney injury.
Q. Lin, Shu Li, Haijiao Jin, Hong Cai, Xuying Zhu, Yuanting Yang, Jingkui Wu, Chao-jun Qi, Xinghua Shao, Jialin Li, Kaiqi Zhang, Wenyan Zhou, Min-fang Zhang, Jiayi Cheng, L. Gu, S. Mou, Z. Ni   +16 more
semanticscholar   +1 more source

Fatostatin induces ferroptosis through inhibition of the AKT/mTORC1/GPX4 signaling pathway in glioblastoma

Cell Death and Disease, 2023
Glioblastoma multiforme (GBM) is the most common and fatal primary malignant central nervous system tumor in adults. Although there are multiple treatments, the median survival of GBM patients is unsatisfactory, which has prompted us to continuously ...
Jiayang Cai, Zhang Ye, Yuanyuan Hu, Liguo Ye, Lun Gao, Yixuan Wang, Qian Sun, Shi’ao Tong, Shenqi Zhang, Liquan Wu, Ji’an Yang, Qianxue Chen   +11 more
semanticscholar   +1 more source

Timosaponin AIII promotes non-small-cell lung cancer ferroptosis through targeting and facilitating HSP90 mediated GPX4 ubiquitination and degradation

International Journal on Biological Sciences, 2023
Timosaponin AIII (Tim-AIII), a steroid saponin, exhibits strong anticancer activity in a variety of cancers, especially breast cancer and liver cancer. However, the underlying mechanism of the effects of Tim-AIII-mediated anti-lung cancer effects remain ...
Cong Zhou, Ting Yu, Rui Zhu, Junjie Lu, Xiaohu Ouyang, Zili Zhang, Qianyun Chen, Junyi Li, J. Cui, Feng Jiang, K. Jin, Alexey Sarapultsev, Fangfei Li, Ge Zhang, Shanshan Luo, Desheng Hu   +15 more
semanticscholar   +1 more source

System Xc −/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy

Frontiers in Pharmacology, 2022
The activation of ferroptosis is a new effective way to treat drug-resistant solid tumors. Ferroptosis is an iron-mediated form of cell death caused by the accumulation of lipid peroxides.
Feng-Jiao Li, Hui-Zhi Long, Zi-Wei Zhou, Hong-Yu Luo, Shuoxi Xu, Lichen Gao   +5 more
semanticscholar   +1 more source

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

Nature Communications, 2021
Glutathione peroxidase 4 (GPX4) utilizes glutathione (GSH) to detoxify lipid peroxidation and plays an essential role in inhibiting ferroptosis. As a selenoprotein, GPX4 protein synthesis is highly inefficient and energetically costly.
Yilei Zhang, Robert V. Swanda, Litong Nie, Xiaoguang Liu, Chao Wang, Hyemin Lee, Guang Lei, Chao Mao, Pranavi Koppula, Weijie Cheng, Jie Zhang, Zhenna Xiao, Zhuang Li, B. Fang, Junjie Chen, Shu-Bing Qian, B. Gan   +16 more
semanticscholar   +1 more source