Results 1 to 10 of about 32,655 (289)
Methylation reader MBD2-mediated GPX4 transcriptional repression drives ovarian granulosa cell ferroptosis in PCOS [PDF]
Redox BiologyArrested follicular development and anovulation are hallmarks of polycystic ovary syndrome (PCOS), in which granulosa cell (GC) ferroptosis is emerging as a potential contributor. However, its precise role and regulation remain largely unknown.
Zhengquan Zhu +11 more
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The mechanism of irisin via Nrf2/GPX4 signaling pathway in alleviating lipopolysaccha-ride-induced acute lung injury in rats [PDF]
Yixue xinzhi zazhi, 2023 Objective To study the role of Nrf2/GPX4 signaling pathway in irisin alleviating lipopoly-saccharide (LPS)-induced acute lung injury in rats.Method Seventy-two healthy male SD rats were ran-domly divided into control group (C group), acute lung injury ...
Jing LUO +4 more
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Effects of nano-selenium and sodium selenite on SelP, GPx4 and SelW genes expression in testes of broiler breeder roosters [PDF]
Bulgarian Journal of Veterinary Medicine, 2020 Fertility is the main element affecting hatchability as an important indicator in breeder flocks’ per-formance. Roosters’ aging reduces their fertility.
H. Jafarzadeh +4 more
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Wedelolactone attenuates cerebral ischemia-reperfusion injury by blocking GPX4-mediated ferroptosis [PDF]
Journal of Men's Health, 2023 Cerebral ischemia is currently the third leading cause of death worldwide. Among its complications, cerebral ischemia-reperfusion (I/R) is considered the most inevitable problem.
Huyin Yang, Dai Liu, Yanping Wang
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European Journal of Histochemistry, 2022 Cellular senescence and ferroptosis are the two main, fine-tuned processes in tissue damage restraint; however, they can be overactivated in pathologies such as nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH), becoming ...
Antonella Vetuschi +6 more
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Animal Cells and Systems, 2021 Selenium (Se) is a vital element of life, which has an important impact on the growth, development, production performance and stress-tolerance of animals. However, it is not entirely clear that how exactly Se works during these processes.
Lu Liu +4 more
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Gut Microbes, 2021 Ferroptosis, a new type of cell death has been found to aggravate intestinal ischemia/reperfusion (I/R) injury. However, little is known about the changes of gut microbiota and metabolites in intestinal I/R and the role of gut microbiota metabolites on ...
Fan Deng +10 more
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GPX4 in cell death, autophagy, and disease
Autophagy, 2023 Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX (phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use of glutathione as a reducing agent in scavenging lipid peroxidation products. There are three GPX4 isoforms: cytosolic (cGPX4), mitochondrial (mGPX4), and nuclear (nGPX4), with distinct ...
Yangchun Xie +3 more
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A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis
Molecular & Cellular Oncology, 2021 Ferroptosis is a cell death mechanism triggered by lipid peroxidation. Our recent study linked cyst(e)ine availability with glutathione peroxidase 4 (GPX4) protein synthesis and ferroptosis mitigation via a Rag-mechanistic target of rapamycin complex 1 ...
Yuelong Yan, Guang Lei, Boyi Gan
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Hypermethylation of the Nrf2 Promoter Induces Ferroptosis by Inhibiting the Nrf2-GPX4 Axis in COPD
International Journal of COPD, 2021 Zixiao Zhang,1,* Congli Fu,1,2,* Jiaxin Liu,1 Xiaoyan Sai,1 Chu Qin,1 Tingting Di,1 Yue Yang,1 Yan Wu,1 Tao Bian1 1Department of Respiratory Medicine, Wuxi People’s Hospital Affiliated to Nanjing, Medical University, Wuxi, Jiangsu, 214023, People’
Zhang Z +8 more
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