Results 241 to 250 of about 40,571 (376)

Inhibition of Mitochondrial Genome-Encoded Mitomir-3 Contributes to Zeb1 Mediated Gpx4 Downregulation and Pro-Ferroptotic Lipid Metabolism to Induce Ferroptosis in Breast Cancer Cells

Amoolya Kandettu, Joydeep Ghosal, Jesline Shaji Tharayil, Raviprasad Kuthethur, Sandeep Mallya, Rekha Koravadi Narasimhamurthy, Kamalesh Dattaram Mumbrekar, Yashwanth Subbannayya, Na An, Raghu Radhakrishnan, Shama Prasada Kabekkodu, Sanjiban Chakrabarty   +11 more
openalex   +1 more source

Peri‐implant hypoxia as a potential barrier against ferroptotic mechanisms during peri‐implant diseases: A cross‐sectional study

Journal of Periodontology, EarlyView.
Abstract Background Hypoxia modulates inflammation and oxidative stress through hypoxia‐inducible factor‐1α (HIF‐1α). Ferroptosis, an iron‐dependent cell death process, is regulated by glutathione peroxidase‐4 (GPX4) and involves lipid peroxidation markers like malondialdehyde (MDA).
Büşra Yılmaz, Ali Gürkan, Beral Afacan, Harika Atmaca, Timur Köse, Gülnur Emingil   +5 more
wiley   +1 more source

Electroacupuncture Pretreatment Ameliorates Perioperative Neurocognitive Disorder in Aged Mice by Inhibiting Ferroptosis Through the SIRT1/NRF2/GPX4 Pathway. [PDF]

J Cell Mol Med
Du Z, Zhang B, Chen T, Lei C, Tang L, Yang S, Wang C.   +6 more
europepmc   +1 more source

Kaempferitrin's Dual Assault: Inducing Apoptosis and Ferroptosis in Diffuse Large B‐Cell Lymphoma via NF‐κB Inactivation

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) is the most common non‐Hodgkin lymphoma and is an aggressive and highly heterogeneous tumor. Kaempferitrin (KPF) is a natural flavonoid glycoside that exerts a protective role in multiple human tumors. However, the impact of KPF on DLBCL remains unclear.
Han‐Shuo Zhang, Xiao‐Dan Zhou, Jin Chen, Ling Wang   +3 more
wiley   +1 more source

<p>Artemisiae Scopariae Herba (Yinchen) suppresses ferroptosis in mice with osteoporosis via the Nrf2/Slc7a11/Gpx4 pathway</p>. [PDF]

Mol Med Rep
Li P, Wan X, Li W, Cheng D, Yang Y, Wang Y, Zhu R, Chen Y, Liu H, Zhang Z.   +9 more
europepmc   +1 more source

Loss of NLN suppresses lung cancer progression by inducing ferroptosis through downregulating m6A methylation of GPX4

Lei Liu, Yinyun Ni, Ying Yang, Gan Zhang, Shengqiang Mao, Ningning Chao, Menglin Yao, Chengdi Wang, Li Zhang   +8 more
openalex   +1 more source

Hypoxia‐Induced Histone Lactylation Promotes Ferroptosis in Cardiomyocytes via the Wnt/β‐Catenin Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study investigated the effects of histone lactylation on ferroptosis in hypoxia‐induced cardiomyocytes. A hypoxia model was established in AC16 cells treated with 2‐Deoxy‐D‐glucose (2‐DG, a glucose analogue), ferrostatin‐1 (Fer‐1, a selective ferroptosis inhibitor), lactate (LA), sh‐β‐catenin (shRNA of β‐catenin), or SKL2001 (an agonist ...
Xin‐Hua Zhu, Jing‐Wen Hou, Zhong‐Ying Lv, Ming‐Hui Sun, Xiao‐Yang Zhang, Lei Zhang, Mei Wang   +6 more
wiley   +1 more source

Oxidative Stress and <i>SIRT1</i>-Nrf2 Anti-Ferroptotic Pathways in Granulosa Cells: A Molecular Key to Follicular Atresia and Ovarian Aging. [PDF]

Int J Mol Sci
Voros C, Chatzinikolaou F, Papadimas G, Polykalas S, Mavrogianni D, Koulakmanidis AM, Athanasiou D, Kanaka V, Bananis K, Athanasiou A, Athanasiou A, Papapanagiotou I, Tsimpoukelis C, Karpouzos A, Daskalaki MA, Kanakas N, Theodora M, Thomakos N, Antsaklis P, Loutradis D, Daskalakis G.   +20 more
europepmc   +1 more source

USP54 Promotes Ferroptosis in Non‐Small Cell Lung Cancer by Mediating FOXA2 Deubiquitination and Enhancing ACSL4 Transcription

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Non‐small cell lung cancer (NSCLC) is the most common type of lung cancer, with a 5‐year survival rate of less than 20% and a high risk of recurrence despite advances in treatment. This study aimed to identify new therapeutic targets to increase the effectiveness of NSCLC treatments.
Rui‐Shi Wei, Yong‐Ping Liu, Chun‐Dong Gu, Shi‐Lei Zhao, Li Feng, Jian‐Rong Yu   +5 more
wiley   +1 more source

Protective role of Zinc glycine in LPS-induced acute kidney injury in geese: Inhibition of oxidative stress and ferroptosis through Nrf2/GPX4 signaling. [PDF]

Poult Sci
Zulfiqar Z, Asif MA, Al-Mitib L, Mumtaz B, Zhaoyang L, Yu Rui Z, Zhu X, Wang Z, Sun H, Cui Y, Liu B, Shi Y.   +11 more
europepmc   +1 more source