Results 241 to 250 of about 29,098 (325)

Ferroptosis is important for <i>Toxoplasma gondii</i> replication and virulence <i>in vitro</i> and <i>in vivo</i>. [PDF]

Virulence
Li LY, Zhou CX, Han B, Elsheikha HM, Qiu HJ, An XD, Zeng T, Liu DA, Yang Q, Zhu XQ, Zhou HY.   +10 more
europepmc   +1 more source

GATA1 Transcriptionally Upregulates LMCD1, Promoting Ferroptosis in Sepsis‐Associated Acute Kidney Injury Through the Hippo/YAP Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis‐associated acute kidney injury (SA‐AKI) is associated with morbidity and mortality. Ferroptosis is associated with the pathophysiology of SA‐AKI. Here, we investigated the role of LIM and cysteine‐rich domain 1 (LMCD1) in the regulation of ferroptosis during SA‐AKI progression.
You‐Qi Zhang, Wei‐Xia Peng, You‐Fu Li, Peng Lu, Hui Liu, Wen‐Guang Liu   +5 more
wiley   +1 more source

Combinational Analysis of Metabolomic and O-GlcNAcylation Omics Reveals the HBP Metabolic Regulation of Chemoresistance via GFPT1/NR3C1 O-GlcNAcylation/GPX4 Axis. [PDF]

Research (Wash D C)
Zhou X, Zhang C, Li L, Feng Z, Bai X, Mei Y, He W, Gou X, Li X.   +8 more
europepmc   +1 more source

Ferroptosis in Pneumoconiosis: From Molecular and Cellular Mechanisms to Therapeutic Strategies

Med Research, EarlyView.
Targeting lung various cells to alleviate pneumoconiosis by suppressing ferroptosis. AAV9‐HGF, adeno‐associated virus‐hepatocyte growth factor; DFP, deferiprone; DHQ, dihydroquercetin; Fer‐1, ferrostatin‐1; IL‐1β, interleukin‐1β; NMN, nicotinamide mononucleotide; sh‐SLC39A14, shRNA targeting solute carrier family 39 member 14; si‐OC‐STAMP, siRNA ...
Mengli Yan, Jing Zhang, Gaili Ji, Xiaobin Fang, Chunheng Mo   +4 more
wiley   +1 more source

Current Insights of the Potential Plant Bioactive Compounds on Modulating the mTOR Signaling Pathway in Regulating Oncological Disorders

Phytotherapy Research, EarlyView.
ABSTRACT Deregulation of the mechanistic target of the rapamycin (mTOR) pathway plays an important role in cancer genesis and progression, making it an attractive target for cancer treatment. Disrupting the mTOR pathway contributes to uncontrolled cell growth, increased proliferation, and enhanced cell survival, all of which are hallmarks of cancer ...
Sonali Khanal, Manjusha Pillai, Md. Shimul Bhuia, Muhammad Torequl Islam, Onkar Sharma, Rachna Verma, Eugenie Nepovimova, Kamil Kuca, Dinesh Kumar, Raihan Chowdhury   +9 more
wiley   +1 more source

KLF13 promotes ferroptosis and chemosensitivity in lung adenocarcinoma. [PDF]

BMC Biol
Shi H, Pan B, Wu G, Liang J, Bian Y, Shan G, Ren S, Bi G, Zhan C, Guo W.   +9 more
europepmc   +1 more source

Embelin Mitigates the Impact of Perinatal Inflammation on Neuron Development by Inhibiting 5‐Lipoxygenase‐Mediated Ferroptosis

Phytotherapy Research, EarlyView.
ABSTRACT Neuronal development in newborns is often constrained by perinatal inflammation, with limited research available on the pathogenesis and treatment strategies for this condition. This study aimed to investigate the neuroprotective effects of Embelin in mitigating perinatal inflammation‐induced neuronal development limitations by targeting 5 ...
Feng Zhang, Mengya Sun, Shiyi Ma, Junfang Sun, Yishi Li, Xianghong Li, Hong Jiang   +6 more
wiley   +1 more source

African swine fever virus A151R downregulates cGAS-STING-mediated IFN-β production by promoting lipid peroxidation through ferritinophagy-induced ferroptosis. [PDF]

Cell Mol Life Sci
Chen Y, Wang J, Zhou Y, Liu M, Li W, Deng Y, Yang Y, Fang C, Niu S, Dai J, Dai H.   +10 more
europepmc   +1 more source

Modulation of miRNAs by Phytochemicals in Cerebral Ischemia: A Systematic Review of In Vitro and In Vivo Studies

Phytotherapy Research, EarlyView.
Schematic representation of how phytochemicals modulate miRNA expression to confer neuroprotection in cerebral ischemia. ABSTRACT Phytochemicals gained substantial interest for their protective action in cerebral ischemia. Additionally, there is a growing body of evidence suggesting that miRs play a role in stroke therapy. However, no systematic review
Joanna Rzemieniec, Mirko Marino, Benedetta Mercuriali, Laura Castiglioni, Paolo Gelosa, Majeda Muluhie, Cristian Del Bo’, Patrizia Riso, Luigi Sironi   +8 more
wiley   +1 more source

FXR acts as a therapeutic target for ulcerative colitis via suppressing ferroptosis. [PDF]

Mol Med
Zhao C, Li X, Mu M, Quan L, Yuan H, Zheng J, Zhao W, Sun X, Yu J.   +8 more
europepmc   +1 more source