Results 1 to 10 of about 94,825 (337)

Cytotoxic granzyme C–expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity

Science Immunology, 2022
Innate lymphocytes are integral components of the cellular immune system that can coordinate host defense against a multitude of challenges and trigger immunopathology when dysregulated.
Briana Nixon, Chun Chou, Chirag Krishna
exaly   +2 more sources

In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET

ACS Central Science, 2021
The biology of human granzymes remains enigmatic in part due to our inability to probe their functions outside of in vitro assays or animal models with divergent granzyme species.
Ning Zhao, Conner Bardine, Yung-Hua Wang
exaly   +2 more sources

Interaction Networks Converging on Immunosuppressive Roles of Granzyme B: Special Niches Within the Tumor Microenvironment

Frontiers in Immunology, 2021
Granzyme B is a renowned effector molecule primarily utilized by CTLs and NK cells against ill-defined and/or transformed cells during immunosurveillance.
Weinan Wang, Rui Zou, Ye Qiu, Jishuang Liu, Yu Xin, Tianzhu He, Tianzhu He, Zhidong Qiu   +7 more
doaj   +2 more sources

Changes in Cell-Mediated Immunity (IFN-γ and Granzyme B) Following Influenza Vaccination

Viruses, 2021
Interferon gamma (IFN-γ) is considered a key moderator of cell-mediated immunity. However, little is known about its association with granzyme B, which plays an important role in the effector function of cytotoxic T lymphocytes (CTLs).
Naruhito Otani, Kazuhiko Nakajima, Kaori Ishikawa, Kaoru Ichiki, Takashi Ueda, Yoshio Takesue, Takuma Yamamoto, Susumu Tanimura, Masayuki Shima, Toshiomi Okuno   +9 more
doaj   +2 more sources

Modulation of Inflammation by Extracellular Granzyme A

Frontiers in Immunology, 2020
Granzyme A (GrA) has long been recognized as one of the key players in the induction of cell death of neoplastic, foreign or infected cells after granule delivery by cytotoxic cells.
Niels Bovenschen
exaly   +2 more sources

Granzyme B Attenuates Bacterial Virulence by Targeting Secreted Factors

iScience, 2020
Summary: Pathogenic bacteria secrete virulence factors that interact with the human host to establish infections. The human immune system evolved multiple mechanisms to fight bacterial invaders, including immune proteases that were demonstrated to ...
Diego López León, Patricia Matthey, Isabelle Fellay, Marianne Blanchard, Denis Martinvalet, Pierre-Yves Mantel, Luis Filgueira, Michael Walch   +7 more
doaj   +2 more sources

RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation.

PLoS Pathogens, 2017
Chikungunya virus (CHIKV) is an arthritogenic alphavirus causing epidemics of acute and chronic arthritic disease. Herein we describe a comprehensive RNA-Seq analysis of feet and lymph nodes at peak viraemia (day 2 post infection), acute arthritis (day 7)
Jane A C Wilson, Natalie A Prow, Wayne A Schroder, Jonathan J Ellis, Helen E Cumming, Linden J Gearing, Yee Suan Poo, Adam Taylor, Paul J Hertzog, Francesca Di Giallonardo, Linda Hueston, Roger Le Grand, Bing Tang, Thuy T Le, Joy Gardner, Suresh Mahalingam, Pierre Roques, Phillip I Bird, Andreas Suhrbier   +18 more
doaj   +2 more sources

Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1β

Journal of Neuroinflammation, 2017
Background The cause of neurodegeneration in progressive forms of multiple sclerosis is unknown. We investigated the impact of specific neuroinflammatory markers on human neurons to identify potential therapeutic targets for neuroprotection against ...
Paul R. Lee, Tory P. Johnson, Sharmilee Gnanapavan, Gavin Giovannoni, Tongguang Wang, Joseph P. Steiner, Marie Medynets, Mark J. Vaal, Valerie Gartner, Avindra Nath   +9 more
doaj   +2 more sources

Role of Serine Proteases at the Tumor-Stroma Interface

Frontiers in Immunology, 2022
During tumor development, invasion and metastasis, the intimate interaction between tumor and stroma shapes the tumor microenvironment and dictates the fate of tumor cells.
Ravichandra Tagirasa, Euna Yoo
doaj   +1 more source

ALFA-PRF: a novel approach to detect murine perforin release from CTLs into the immune synapse

Frontiers in Immunology, 2022
When killing through the granule exocytosis pathway, cytotoxic lymphocytes release key effector molecules into the immune synapse, perforin and granzymes, to initiate target cell killing.
Jesse A. Rudd-Schmidt, Romain F. Laine, Romain F. Laine, Romain F. Laine, Tahereh Noori, Tahereh Noori, Amelia J. Brennan, Ilia Voskoboinik, Ilia Voskoboinik   +8 more
doaj   +1 more source