Results 11 to 20 of about 94,825 (337)

Granzyme [PDF]

Definitions, 2020
A. Gressner, O. Gressner
semanticscholar   +4 more sources

Immunotherapeutic targeting of membrane Hsp70-expressing tumors using recombinant human granzyme B [PDF]

, 2012
Background: We have previously reported that human recombinant granzyme B (grB) mediates apoptosis in membrane heat shock protein 70 (Hsp70)-positive tumor cells in a perforin-independent ...
AL Rerole, Alan G. Pockley, Andreas Kirschner, Axel Walch, Brigitte T. Doß, C Botzler, C Botzler, C Gross, D Kaiserman, D Schilling, DR Ciocca, E Schmitt, FC Kurschus, G MacDonald, G Multhoff, G Multhoff, Gabriele Multhoff, Gemma A. Foulds, H Dertinger, J Friedrich, J Friedrich, J Nylandsted, J Sun, J Thiery, JA Trapani, K Pfister, L Chavez-Galan, M Gehrmann, M Gehrmann, M Gehrmann, M Gehrmann, M Gehrmann, M Wang, Mathias Gehrmann, Michael Platten, MS Buzza, RZ Lin, S Balkow, S Mahrus, S Stangl, S Stangl, SP Cullen, Stefan Stangl, SW Krause, U Giesubel, V Milani, WA Boivin, Wolfgang Sievert, Y Liu, Y Liu, Z Xia   +50 more
core   +15 more sources

Editorial: Roles of granzymes in inflammation, aging, and autoimmunity [PDF]

Frontiers in Immunology
Fehim Esen, Christopher T. Turner
doaj   +2 more sources

Granzyme B in Autoimmune Skin Disease

Biomolecules, 2023
Autoimmune diseases often present with cutaneous symptoms that contribute to dysfunction, disfigurement, and in many cases, reduced quality-of-life. Unfortunately, treatment options for many autoimmune skin diseases are limited.
A. Gleave, D. Granville
semanticscholar   +1 more source

Granzyme A. [PDF]

Methods in Enzymology, 2020
M. Simon, M. Kramer
semanticscholar   +2 more sources

Extended cleavage specificities of human granzymes A and K, two closely related enzymes with conserved but still poorly defined functions in T and NK cell-mediated immunity

Frontiers in Immunology, 2023
Granzymes A and K are two highly homologous serine proteases expressed by mammalian cytotoxic T cells (CTL) and natural killer cells (NK). Granzyme A is the most abundant of the different granzymes (gzms) expressed by these two cell types.
Erdem Aybay, Jinhye Ryu, Zhirong Fu, Srinivas Akula, Srinivas Akula, Erika Mendez Enriquez, Jenny Hallgren, Sara Wernersson, Anna-Karin Olsson, Lars Hellman   +9 more
doaj   +1 more source

NF-κB c-Rel Is Dispensable for the Development but Is Required for the Cytotoxic Function of NK Cells

Frontiers in Immunology, 2021
Natural Killer (NK) cells are cytotoxic lymphocytes critical to the innate immune system. We found that germline deficiency of NF-κB c-Rel results in a marked decrease in cytotoxic function of NK cells, both in vitro and in vivo, with no significant ...
Yorleny Vicioso, Derek P. Wong, Nand K. Roy, Nayanika Das, Keman Zhang, Parameswaran Ramakrishnan, Parameswaran Ramakrishnan, Reshmi Parameswaran, Reshmi Parameswaran   +8 more
doaj   +1 more source

Granzyme B inhibition reduces disease severity in autoimmune blistering diseases

Nature Communications, 2021
Pemphigoid diseases refer to a group of severe autoimmune skin blistering diseases characterized by subepidermal blistering and loss of dermal-epidermal adhesion induced by autoantibody and immune cell infiltrate at the dermal-epidermal junction and ...
S. Hiroyasu, Matthew R. Zeglinski, Hongyan Zhao, M. Pawluk, Christopher T. Turner, A. Kasprick, C. Tateishi, W. Nishie, A. Burleigh, P. Lennox, N. Van Laeken, N. Carr, F. Petersen, R. Crawford, H. Shimizu, D. Tsuruta, R. Ludwig, D. Granville   +17 more
semanticscholar   +1 more source

The Expanding Arsenal of Cytotoxic T Cells

Frontiers in Immunology, 2022
Cytotoxic T cells (CTLs) are the main cellular mediators of the adaptive immune defenses against intracellular pathogens and malignant cells. Upon recognition of specific antigen on their cellular target, CTLs assemble an immunological synapse where they
Chiara Cassioli, Cosima T. Baldari
doaj   +1 more source

A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies

Nature Communications, 2022
Immunotherapy promotes the attack of cancer cells by the immune system; however, it is difficult to detect early responses before changes in tumor size occur.
Jamie I. Scott, Lorena Mendive-Tapia, Doireann Gordon, N. Barth, Emily J. Thompson, Zhiming Cheng, David Taggart, T. Kitamura, A. Bravo-Blas, Edward W. Roberts, Jordi Juárez-Jiménez, J. Michel, B. Piet, I. J. D. de Vries, M. Verdoes, John C. Dawson, N. Carragher, Richard O ’ Connor, A. Akram, M. Frame, A. Serrels, M. Vendrell   +21 more
semanticscholar   +1 more source