Temporal Dynamics of Serum Perforin and Granzyme during the Acute Phase of SARS-CoV-2 Infection
Vaccines, 2023 Background: As many SARS-CoV-2 infections are asymptomatic, it could be useful to be able to determine how much time has passed since infection. We explored the changes in the temporal levels of T cell-related proteins (including perforin and granzymes ...
MD Tazikur Rahman +5 more
doaj +1 more source
Intracellular and Extracellular Roles of Granzyme K
Frontiers in Immunology, 2021 Granzymes are a family of serine proteases stored in granules inside cytotoxic cells of the immune system. Granzyme K (GrK) has been only limitedly characterized and knowledge on its molecular functions is emerging.
Annemieke C. Bouwman +4 more
semanticscholar +1 more source
Production and characterization of monoclonal antibodies raised against recombinant human granzymes A and B and showing cross reactions with the natural proteins [PDF]
, 1993 The human serine proteases granzymes A and B are expressed in cytotoplasmic granules of activated cytotoxic T lymphocytes and natural killer cells. Recombinant granzyme A and granzyme B proteins were produced in bacteria, purified and then used to raise ...
Borst, Jannie +9 more
core +10 more sources
In vivo bioluminescence imaging of granzyme B activity in tumor response to cancer immunotherapy.
Cell Chemical Biology, 2022 Cancer immunotherapy has revolutionized the treatment of cancer, but only a small subset of patients benefits from this new treatment regime. Imaging tools are useful for early detection of tumor response to immunotherapy and probing the dynamic and ...
Min Chen +10 more
semanticscholar +1 more source
Endometrial Cancer Suppresses CD8+ T Cell-Mediated Cytotoxicity in Postmenopausal Women
Frontiers in Immunology, 2021 Endometrial cancer is the most common gynecological cancer. To investigate how it suppresses host immune function, we isolated CD8+ T cells from endometrial endometroid carcinomas and adjacent non-cancerous endometrium and determined if the tumor ...
Mickey V. Patel +5 more
doaj +1 more source
Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling
Nature Communications, 2020 Acute myocardial infarction is a common condition responsible for heart failure and sudden death. Here, we show that following acute myocardial infarction in mice, CD8+ T lymphocytes are recruited and activated in the ischemic heart tissue and release ...
Icía Santos-Zas +30 more
semanticscholar +1 more source
Acta Veterinaria, 2023 Some cats live at home with their owners while others live unattended on the streets or in shelters. One might expect that the owned cats would be better prepared for diseases with vaccinations, and good care and feeding conditions whereas the stray cats
Temizkan Mehmet Cevat +4 more
doaj +1 more source
bioRxiv, 2021 Excessive shedding of enterocytes into the intestinal lumen is observed in inflammatory bowel disease and is correlated with disease relapse. However, the mechanisms underlying this phenomenon remain unclear.
Madeleine D. Hu +10 more
semanticscholar +1 more source
Perforinopathy: a spectrum of human immune disease caused by defective perforin delivery or function
Frontiers in Immunology, 2013 Congenital perforin deficiency is considered a rare cause of human immunopathology and immune dysregulation, and classically presents as a fatal illness early in infancy.
Joseph A. Trapani, Ilia eVoskoboinik
doaj +1 more source
Widespread and dynamic expression of granzyme C by skin-resident antiviral T cells
Frontiers in Immunology, 2023 After recognition of cognate antigen (Ag), effector CD8+ T cells secrete serine proteases called granzymes in conjunction with perforin, allowing granzymes to enter and kill target cells.
Ramon A. Lujan +6 more
doaj +1 more source