Results 21 to 30 of about 933 (174)

First Investigation of Grass Carp Reovirus (GCRV) Infection in Amphioxus: Insights into Pathological Effects, Transmission, and Transcriptomic Responses. [PDF]

Viruses
Amphioxus belongs to the subphylum Cephalochordata and occupies a transitional position in evolution between invertebrates and vertebrates. Due to the lack of viruses suitable for immunostimulation in amphioxus, this study for the first time explored the pathogenicity and waterborne transmission of Grass Carp Reovirus (GCRV), a double-stranded RNA ...
Lin J, Yang M, Yang H, Ji G, Liu Z.
europepmc   +4 more sources

Inducible Nitric Oxide Synthase (iNOS) Mediates Vascular Endothelial Cell Apoptosis in Grass Carp Reovirus (GCRV)-Induced Hemorrhage. [PDF]

Int J Mol Sci, 2019
Hemorrhage is one of the most obvious pathological phenomena in grass carp reovirus (GCRV) infection. The etiology of GCRV-induced hemorrhage is unclear. We found inducible nitric oxide synthase (iNOS) may relate to viral hemorrhage according to the previous studies, which is expressed at high levels after GCRV infection and is related to apoptosis. In
Liang B, Su J.
europepmc   +4 more sources

The VP2 protein of grass carp reovirus (GCRV) expressed in a baculovirus exhibits RNA polymerase activity. [PDF]

Virol Sin, 2014
The double-shelled grass carp reovirus (GCRV) is capable of endogenous RNA transcription and processing. Genome sequence analysis has revealed that the protein VP2, encoded by gene segment 2 (S2), is the putative RNA-dependent RNA polymerase (RdRp). In previous work, we have ex-pressed the functional region of VP2 that is associated with RNA polymerase
Yan L, Liu H, Li X, Fang Q.
europepmc   +4 more sources

Identification, Virulence, and Molecular Characterization of a Recombinant Isolate of Grass Carp Reovirus Genotype I

Viruses, 2021
The hemorrhagic disease of grass carp (HDGC) caused by grass carp reovirus (GCRV) still poses a great threat to the grass carp industry. Isolation and identification of the GCRV genotype I (GCRV-I) has been rarely reported in the past decade.
Weiwei Zeng, Sven M. Bergmannc, Hanxu Dong, Ying Yang, Minglin Wu, Hong Liu, Yanfeng Chen, Hua Li   +7 more
doaj   +1 more source

Cell surface heparan sulfate is an attachment receptor for grass carp reovirus. [PDF]

iScience
Summary: Grass carp reovirus (GCRV) causes hemorrhagic disease in grass carp, leading to significant economic losses in China’s aquaculture. However, the cellular receptors responsible for the initiation of GCRV infection remain unclear.
Wang Q, Wang H, Wang X, Yang C, Li Y, Liao L, Zhu Z, Wang Y, He L.   +8 more
europepmc   +2 more sources

Identification and characterization of a novel reovirus strain isolated fromgrass carp (Ctenopharyngodon idella). [PDF]

Virol J
Background Grass carp (Ctenopharyngodon idella) hemorrhagic disease (GCHD) is a devastating disease that leads to substantial economic losses in the freshwater aquaculture industry.
Kong W, Ding G, Zhang Q, Yuan X, Zhu Y, Ma L, Cai C, Shi Y, Zhang Q, Xu Z.   +9 more
europepmc   +2 more sources

Characterization of grass carp FosB, Fosl2, JunD transcription factors in response to GCRV infection

Aquaculture and Fisheries, 2022
Activating protein-1 (AP-1) composed of Jun and Fos family proteins, which are frequently activated by pathogens to induce cellular inflammation and immune responses. In this study, by using RNA sequencing (RNA-seq) technology, we found that FosB, Fosl2,
Fei Yu, Wanjuan Li, Longlong Wang, Shunzheng Que, Liqun Lu   +4 more
doaj   +1 more source

Self-assembled nanoparticle vaccine comprised of multiple epitopes provides robust protective immunity against reoviruses in fish model. [PDF]

Cell Commun Signal
Grass carp reovirus type II (GCRV-II) has inflicted substantial economic damage to aquaculture industry due to highly contagious. To combat epidemic GCRV-II, we rational designed and constructed a multi-epitope nanoparticle vaccine (Pep-Fn) that ...
Xu FF, Zhao Z, Deng ZY, Tang JL, Zhu B.
europepmc   +2 more sources

ATG5 negatively regulates grass carp reovirus-induced immune-inflammatory response by degrading RIG-I and MDA5. [PDF]

J Virol
Grass carp reovirus (GCRV) is the most virulent aquareovirus, inducing hemorrhagic disease that results in significant economic losses for the grass carp aquaculture industry in China.
Chu P, Wang Y, Shen J, Wang Y, Chang G, He L.   +5 more
europepmc   +2 more sources

Grass Carp Reovirus Induces Formation of Lipid Droplets as Sites for Its Replication and Assembly

mBio, 2022
Grass carp is an important commercial fish in China that is plagued by various diseases, especially the hemorrhagic disease induced by grass carp reovirus (GCRV).
Libo He, Qian Wang, Xinyu Liang, Hanyue Wang, Pengfei Chu, Cheng Yang, Yongming Li, Lanjie Liao, Zuoyan Zhu, Yaping Wang   +9 more
doaj   +1 more source