Results 21 to 30 of about 270,384 (142)

Type II Grass Carp Reovirus Infects Leukocytes but Not Erythrocytes and Thrombocytes in Grass Carp (Ctenopharyngodon idella)

Viruses, 2021
Grass carp reovirus (GCRV) causes serious losses to the grass carp industry. At present, infectious tissues of GCRV have been studied, but target cells remain unclear. In this study, peripheral blood cells were isolated, cultured, and infected with GCRV.
Ling Yang, Jianguo Su
doaj   +2 more sources

Protective roles of grass carp Ctenopharyngodon idella Mx isoforms against grass carp reovirus.

PLoS ONE, 2012
BackgroundMyxovirus resistance (Mx) proteins are crucial effectors of the innate antiviral response against a wide range of viruses, mediated by the type I interferon (IFN-I) signaling pathway.
Limin Peng, Chunrong Yang, Jianguo Su, Jianguo Su   +3 more
doaj   +2 more sources

Grass carp catalase inhibits GCRV replication through ROS scavenging-mediated immune suppression and autophagy [PDF]

Virulence
Catalase (CAT) is a key antioxidant enzyme that eliminates reactive oxygen species (ROS), thereby protecting organisms from oxidative stress and maintaining cellular homeostasis.
Xuyang Wang, Xiaowen Zou, Linlin Liu, Xinyu Liang, Hanyue Wang, Cheng Yang, Yongming Li, Lanjie Liao, Zuoyan Zhu, Yaping Wang, Jingjing Zhao, Libo He   +11 more
doaj   +2 more sources

Grass carp reovirus activates fish Ppp1r3g to suppress innate immunity and exacerbate hemorrhage via the 14-3-3ζ/Itgb3 signaling axis. [PDF]

PLoS Pathogens
Protein phosphatase 1 regulatory subunit 3G (PPP1R3G) is one of the regulatory subunits of protein phosphatase 1 (PP1). Current research on PPP1R3G is primarily focused on glycogen synthesis and lipid metabolism.
Ruyi Wang, Man Zhou, Yuxuan Wang, Xudong Hu, Han Zhang, Hong Cao   +5 more
doaj   +2 more sources

Sialic acid serves as a functional receptor for grass carp reovirus. [PDF]

PLoS Pathogens
Grass carp reovirus (GCRV) causes hemorrhagic disease and substantial economic losses in the aquaculture of grass carp (Ctenopharyngodon idella), a commercially important fish species in China.
Qian Wang, Zichao Peng, Bin Gui, Yongming Li, Lanjie Liao, Zuoyan Zhu, Yaping Wang, Libo He   +7 more
doaj   +2 more sources

GCRV-II Triggers B and T Lymphocyte Apoptosis via Mitochondrial ROS Pathway [PDF]

Viruses
Grass carp reovirus (GCRV), particularly the highly prevalent genotype II (GCRV-II), is known to infect peripheral blood leukocytes (PBLs) of grass carp. However, it is unclear whether GCRV-II can induce apoptosis in bystander lymphocytes within infected
Jie Wang, Wen-Jing Dong, Chang-Song Wu, Tian-Tian Tian, Xu-Jie Zhang, Yong-An Zhang   +5 more
doaj   +2 more sources

Grass carp reovirus VP4 manipulates TOLLIP to degrade STING for inhibition of IFN production [PDF]

Journal of Virology
Although fish possess an effective interferon (IFN) system to defend against viral infection, grass carp reovirus (GCRV) still causes epidemic hemorrhagic disease and tremendous economic loss in grass carp.
Yang-Yang Wang, Xue-Li Wang, Zhuo-Cong Li, Can Zhang, Xiao Xu, Bao-Jie Cui, Meng-Ze Tian, Chu-Jing Zhou, Na Xu, Yue Wu, Xiao-Li Yang, Dan-Dan Chen, Long-Feng Lu, Shun Li   +13 more
doaj   +2 more sources

Coordination of oxysterol binding protein 1 and VAP-A/B modulates the generation of cholesterol and viral inclusion bodies to promote grass carp reovirus replication [PDF]

Frontiers in Immunology
Similar to other RNA viruses, grass carp reovirus, the causative agent of the hemorrhagic disease, replicates in cytoplasmic viral inclusion bodies (VIBs), orchestrated by host proteins and lipids.
Jia Qi Li, Jia Qi Li, Jie Zhang, Jie Zhang, Yang Chen, Yang Chen, Tao Le, Ming Xian Chang, Ming Xian Chang   +8 more
doaj   +2 more sources

Fish TOLLIP manipulates ATG5 for autophagic degradation of STING to attenuate antiviral interferon responses. [PDF]

PLoS Pathogens
While robust interferon (IFN) responses in fish are critical for viral clearance, dysregulated signalling can trigger detrimental hyperinflammation, necessitating precise immunoregulatory mechanisms. This study identified Toll-interacting protein (TOLLIP)
Meng-Ze Tian, Yang-Yang Wang, Bao-Jie Cui, Xiao Xu, Chu-Jing Zhou, Can Zhang, Zhuo-Cong Li, Meng-Qian Hong, Na Xu, Dan-Dan Chen, Long-Feng Lu, Shun Li   +11 more
doaj   +2 more sources

Grass Carp Reovirus (GCRV) Giving Its All to Suppress IFN Production by Countering MAVS Signaling Transduction. [PDF]

Front Immunol, 2020
Viruses typically target host RIG-I-like receptors (RLRs), a group of key factors involved in interferon (IFN) production, to enhance viral infection.
Lu LF, Li ZC, Zhang C, Zhou XY, Zhou Y, Jiang JY, Chen DD, Li S, Zhang YA.   +8 more
europepmc   +2 more sources