Results 31 to 40 of about 753 (151)

Coordination of oxysterol binding protein 1 and VAP-A/B modulates the generation of cholesterol and viral inclusion bodies to promote grass carp reovirus replication [PDF]

Frontiers in Immunology
Similar to other RNA viruses, grass carp reovirus, the causative agent of the hemorrhagic disease, replicates in cytoplasmic viral inclusion bodies (VIBs), orchestrated by host proteins and lipids.
Jia Qi Li, Jia Qi Li, Jie Zhang, Jie Zhang, Yang Chen, Yang Chen, Tao Le, Ming Xian Chang, Ming Xian Chang   +8 more
doaj   +2 more sources

Comparative Transcriptomics Analysis Reveals Unique Immune Response to Grass Carp Reovirus Infection in Barbel Chub (Squaliobarbus curriculus) [PDF]

Biology
Grass carp (Ctenopharyngodon idella) and barbel chub (Squaliobarbus curriculus)—both Leuciscinae subfamily species—demonstrate differences in grass carp reovirus (GCRV) infection resistance.
Yuhong Huang, Xiaodong Wang, Zhao Lv, Xudong Hu, Baohong Xu, Hong Yang, Tiaoyi Xiao, Qiaolin Liu   +7 more
doaj   +2 more sources

Fish TOLLIP manipulates ATG5 for autophagic degradation of STING to attenuate antiviral interferon responses. [PDF]

PLoS Pathogens
While robust interferon (IFN) responses in fish are critical for viral clearance, dysregulated signalling can trigger detrimental hyperinflammation, necessitating precise immunoregulatory mechanisms. This study identified Toll-interacting protein (TOLLIP)
Meng-Ze Tian, Yang-Yang Wang, Bao-Jie Cui, Xiao Xu, Chu-Jing Zhou, Can Zhang, Zhuo-Cong Li, Meng-Qian Hong, Na Xu, Dan-Dan Chen, Long-Feng Lu, Shun Li   +11 more
doaj   +2 more sources

Bid-deficient fish delay grass carp reovirus (GCRV) replication and attenuate GCRV-triggered apoptosis. [PDF]

Oncotarget, 2017
Bid, BH3-interacting domain death agonist, is a pro-apoptotic BH3-only member of Bcl-2 family, playing an important role in apoptosis. In the study, Bid genes from grass carp (Ctenopharyngodon idellus) and rare minnow (Gobiocypris rarus), named CiBid and GrBid, were cloned and analyzed.
He L, Wang H, Luo L, Li Y, Huang R, Liao L, Zhu Z, Wang Y.   +7 more
europepmc   +3 more sources

Germination-Arrest Bacillus subtilis Spores as An Oral Delivery Vehicle of Grass Carp Reovirus (GCRV) Vp7 Antigen Augment Protective Immunity in Grass Carp (Ctenopharyngodon idella). [PDF]

Genes (Basel), 2020
Oral vaccination is a practical method for the active immunization of farmed fish in the matter of animal welfare and handling costs. However, it always shows insufficient protective immunity, mainly due to antigen degradation in the gastrointestinal tract (GIT).
Sun R, Zhang M, Chen H, Wei Y, Ning D.
europepmc   +4 more sources

First Investigation of Grass Carp Reovirus (GCRV) Infection in Amphioxus: Insights into Pathological Effects, Transmission, and Transcriptomic Responses. [PDF]

Viruses
Amphioxus belongs to the subphylum Cephalochordata and occupies a transitional position in evolution between invertebrates and vertebrates. Due to the lack of viruses suitable for immunostimulation in amphioxus, this study for the first time explored the pathogenicity and waterborne transmission of Grass Carp Reovirus (GCRV), a double-stranded RNA ...
Lin J, Yang M, Yang H, Ji G, Liu Z.
europepmc   +4 more sources

Inducible Nitric Oxide Synthase (iNOS) Mediates Vascular Endothelial Cell Apoptosis in Grass Carp Reovirus (GCRV)-Induced Hemorrhage. [PDF]

Int J Mol Sci, 2019
Hemorrhage is one of the most obvious pathological phenomena in grass carp reovirus (GCRV) infection. The etiology of GCRV-induced hemorrhage is unclear. We found inducible nitric oxide synthase (iNOS) may relate to viral hemorrhage according to the previous studies, which is expressed at high levels after GCRV infection and is related to apoptosis. In
Liang B, Su J.
europepmc   +4 more sources

The VP2 protein of grass carp reovirus (GCRV) expressed in a baculovirus exhibits RNA polymerase activity. [PDF]

Virol Sin, 2014
The double-shelled grass carp reovirus (GCRV) is capable of endogenous RNA transcription and processing. Genome sequence analysis has revealed that the protein VP2, encoded by gene segment 2 (S2), is the putative RNA-dependent RNA polymerase (RdRp). In previous work, we have ex-pressed the functional region of VP2 that is associated with RNA polymerase
Yan L, Liu H, Li X, Fang Q.
europepmc   +4 more sources

Characterization of grass carp FosB, Fosl2, JunD transcription factors in response to GCRV infection

Aquaculture and Fisheries, 2022
Activating protein-1 (AP-1) composed of Jun and Fos family proteins, which are frequently activated by pathogens to induce cellular inflammation and immune responses. In this study, by using RNA sequencing (RNA-seq) technology, we found that FosB, Fosl2,
Fei Yu, Wanjuan Li, Longlong Wang, Shunzheng Que, Liqun Lu   +4 more
doaj   +1 more source

Grass Carp Reovirus Induces Formation of Lipid Droplets as Sites for Its Replication and Assembly

mBio, 2022
Grass carp is an important commercial fish in China that is plagued by various diseases, especially the hemorrhagic disease induced by grass carp reovirus (GCRV).
Libo He, Qian Wang, Xinyu Liang, Hanyue Wang, Pengfei Chu, Cheng Yang, Yongming Li, Lanjie Liao, Zuoyan Zhu, Yaping Wang   +9 more
doaj   +1 more source