Results 11 to 20 of about 6,416,183 (264)

Coupled local translation and degradation regulate growth cone collapse

Nature Communications, 2015
Local translation mediates axonal responses to Semaphorin3A (Sema3A) and other guidance cues. However, only a subset of the axonal proteome is locally synthesized, whereas most proteins are trafficked from the soma.
Alessia Deglincerti, Yaobin Liu, D. Çolak, U. Hengst, Guoqiang Xu, S. Jaffrey   +5 more
semanticscholar   +1 more source

The dynamics of growth cone morphology

BMC Biology, 2015
Normal brain function depends on the development of appropriate patterns of neural connections. A critical role in guiding axons to their targets during neural development is played by neuronal growth cones.
G. Goodhill, R. Faville, Daniel J. Sutherland, Brendan A. Bicknell, A. W. Thompson, Z. Pujic, Biao Sun, Elizabeth M. Kita, Ethan K. Scott   +8 more
semanticscholar   +1 more source

Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2

BMC Biology, 2014
BackgroundIn the adult central nervous system, axonal regeneration is abortive. Regulators of microtubule dynamics have emerged as attractive targets to promote axonal growth following injury as microtubule organization is pivotal for growth cone ...
M. Liz, F. Mar, T. Santos, Helena I Pimentel, Ana M Marques, Marlene Morgado, Sílvia Vieira, V. Sousa, Hayley Pemble, T. Wittmann, C. Sutherland, J. Woodgett, M. Sousa   +12 more
semanticscholar   +1 more source

The UNC-6/Netrin receptors UNC-40/DCC and UNC-5 inhibit growth cone filopodial protrusion via UNC-73/Trio, Rac-like GTPases and UNC-33/CRMP

Development, 2014
UNC-6/Netrin is a conserved axon guidance cue that can mediate both attraction and repulsion. We previously discovered that attractive UNC-40/DCC receptor signaling stimulates growth cone filopodial protrusion and that repulsive UNC-40–UNC-5 heterodimers
Adam D Norris, Lakshmi Sundararajan, D. E. Morgan, Z. Roberts, E. Lundquist   +4 more
semanticscholar   +1 more source

Collapsin Response Mediator Protein 4 Regulates Growth Cone Dynamics through the Actin and Microtubule Cytoskeleton*

Journal of Biological Chemistry, 2014
Background: Intricate regulation of the growth cone cytoskeleton controls growth cone dynamics. Results: Loss of CRMP4 disrupts growth cone cytoskeletal dynamics, growth cone expansion, and axon growth.
M. Khazaei, Marie-Pier Girouard, R. Alchini, Stephan Ong Tone, Tadayuki Shimada, S. Bechstedt, M. Cowan, D. Guillet, P. Wiseman, G. Brouhard, J. Cloutier, A. Fournier   +11 more
semanticscholar   +1 more source

The Role of Arp2/3 in Growth Cone Actin Dynamics and Guidance Is Substrate Dependent

Journal of Neuroscience, 2014
During development extrinsic guidance cues modulate the peripheral actin network in growth cones to direct axons to their targets. We wanted to understand the role of the actin nucleator Arp2/3 in growth cone actin dynamics and guidance.
José E San Miguel-Ruiz, Paul C. Letourneau   +1 more
semanticscholar   +1 more source

Val66Met Polymorphism of BDNF Alters Prodomain Structure to Induce Neuronal Growth Cone Retraction

Nature Communications, 2013
A common single-nucleotide polymorphism (SNP) in the human brain-derived neurotrophic factor (BDNF) gene results in a Val66Met substitution in the BDNF prodomain region.
A. Anastasía, Katrin Deinhardt, M. Chao, N. Will, Krithi Irmady, F. Lee, B. Hempstead, C. Bracken   +7 more
semanticscholar   +1 more source

Antagonistic Functions of Dishevelleds Regulate Frizzled3 Endocytosis via Filopodia Tips in Wnt-Mediated Growth Cone Guidance

Journal of Neuroscience, 2013
How growth cones detect small concentration differences of guidance cues for correct steering remains a long-standing puzzle. Commissural axons engage planar cell polarity (PCP) signaling components to turn anteriorly in a Wnt gradient after midline ...
Keisuke Onishi, B. Shafer, C. Lo, F. Tissir, A. Goffinet, Y. Zou   +5 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Down Syndrome Cell Adhesion Molecule (DSCAM) Associates with Uncoordinated-5C (UNC5C) in Netrin-1-mediated Growth Cone Collapse*

Journal of Biological Chemistry, 2012
Background: Coordination of the signaling cascades downstream of netrin receptors is essential in axon guidance. Results: DSCAM collaborates with UNC5C to mediate netrin-1-induced axon growth cone collapse through the assembly of a signaling complex ...
Anish A. Purohit, Weiquan Li, C. Qu, T. Dwyer, Q. Shao, K. Guan, Guofa Liu   +6 more
semanticscholar   +1 more source