Results 11 to 20 of about 372,166 (319)
Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration [PDF]
eLife, 2016 Mechanistic studies of axon growth during development are beneficial to the search for neuron-intrinsic regulators of axon regeneration. Here, we discovered that, in the developing neuron from rat, Akt signaling regulates axon growth and growth cone ...
Hyo Rim Ko +9 more
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Growth cone advance requires EB1 as revealed by genomic replacement with a light-sensitive variant [PDF]
eLife, 2023 A challenge in analyzing dynamic intracellular cell biological processes is the dearth of methodologies that are sufficiently fast and specific to perturb intracellular protein activities.
Alessandro Dema +4 more
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Glial Cell-Axonal Growth Cone Interactions in Neurodevelopment and Regeneration [PDF]
Frontiers in Neuroscience, 2020 The developing nervous system is a complex yet organized system of neurons, glial support cells, and extracellular matrix that arranges into an elegant, highly structured network.
Michael J. Rigby +8 more
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Neuronal Growth Cone Size-Dependent and -Independent Parameters of Microtubule Polymerization [PDF]
Frontiers in Cellular Neuroscience, 2018 Migration and pathfinding of neuronal growth cones during neurite extension is critically dependent on dynamic microtubules. In this study we sought to determine, which aspects of microtubule polymerization relate to growth cone morphology and migratory ...
Alexa Kiss +4 more
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Non-Muscle Myosin II in Axonal Cell Biology: From the Growth Cone to the Axon Initial Segment [PDF]
Cells, 2020 By binding to actin filaments, non-muscle myosin II (NMII) generates actomyosin networks that hold unique contractile properties. Their dynamic nature is essential for neuronal biology including the establishment of polarity, growth cone formation and ...
Ana Rita Costa, Monica M. Sousa
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Model for Coordination of Microtubule and Actin Dynamics in Growth Cone Turning [PDF]
Frontiers in Cellular Neuroscience, 2018 In the developing nervous system, axons are guided to their synaptic targets by motile structures at the axon tip called growth cones, which reorganize their cytoskeleton in order to steer in response to chemotactic cues. Growth cone motility is mediated
Erin M. Craig
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Regulation of growth cone motility [PDF]
Cell Motility, 1991 Nerve growth cones are the motile tips of elongating axons and dendrites. The migration and behavior of growth cones are responsible for axonal pathfinding to synaptic targets, and for the branching patterns of dendritic trees. Growth cones are studied at all levels of organization, molecular, cellular, and within intact embryos. Preparations of growth
Paul C. Letourneau, Christopher Cypher
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The dynamics of growth cone morphology [PDF]
BMC Biology, 2015 Normal brain function depends on the development of appropriate patterns of neural connections. A critical role in guiding axons to their targets during neural development is played by neuronal growth cones. These have a complex and rapidly changing morphology; however, a quantitative understanding of this morphology, its dynamics and how these are ...
Goodhill, Geoffrey J. +8 more
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Growth cone dynamics during the migration of an identified commissural growth cone [PDF]
The Journal of Neuroscience, 1993 We have used time-lapse video microscopy to study the behavior of a neuron, Q1, that pioneers the posterior commissure of the embryonic grasshopper. Our goal is to use time-lapse video as a tool to acquire a precise picture of normal development over time, and thereby identify stereotypic activities that might indicate important interactions necessary ...
Paul Z. Myers, Michael J. Bastiani
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Mechanisms of growth cone repulsion [PDF]
F1000 Biology Reports, 2010 Research conducted in the last century suggested that chemoattractants guide cells or their processes to appropriate locations during development. Today, we know that many of the molecules involved in cellular guidance can act as chemorepellents that prevent migration into inappropriate territories. Here, we review some of the early seminal experiments
Judith S. Eisen, Catherine E. Krull
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