Functional Redundancy of Cyclase-Associated Proteins CAP1 and CAP2 in Differentiating Neurons
Cells, 2021 Cyclase-associated proteins (CAPs) are evolutionary-conserved actin-binding proteins with crucial functions in regulating actin dynamics, the spatiotemporally controlled assembly and disassembly of actin filaments (F-actin).
Felix Schneider +3 more
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Frontiers in Neuroscience, 2017 The role of mitochondria within injured neurons is an area of active interest since these organelles are vital for the production of cellular energy in the form of ATP.
Wendy M. Knowlton +6 more
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Participation of L-Lactate and Its Receptor HCAR1/GPR81 in Neurovisual Development
Cells, 2021 During the development of the retina and the nervous system, high levels of energy are required by the axons of retinal ganglion cells (RGCs) to grow towards their brain targets.
Samuel Laroche +5 more
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eLife, 2018 A presynaptic adhesion G-protein-coupled receptor, latrophilin-1, and a postsynaptic transmembrane protein, Lasso/teneurin-2, are implicated in trans-synaptic interaction that contributes to synapse formation. Surprisingly, during neuronal development, a
Nickolai V Vysokov +10 more
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Neuronal deletion of GSK3beta increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2 [PDF]
, 2014 BACKGROUND: In the adult central nervous system, axonal regeneration is abortive. Regulators of microtubule dynamics have emerged as attractive targets to promote axonal growth following injury as microtubule organization is pivotal for growth cone ...
Liz, Márcia A. +12 more
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An Integrated Cytoskeletal Model of Neurite Outgrowth
Frontiers in Cellular Neuroscience, 2018 Neurite outgrowth underlies the wiring of the nervous system during development and regeneration. Despite a significant body of research, the underlying cytoskeletal mechanics of growth and guidance are not fully understood, and the relative ...
Kyle E. Miller +4 more
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Cue-Polarized Transport of β-actin mRNA Depends on 3′UTR and Microtubules in Live Growth Cones
Frontiers in Cellular Neuroscience, 2018 Guidance cues trigger fast responses in axonal growth cones such as directional turning and collapse that require local protein synthesis. An attractive cue-gradient, such as Netrin-1, triggers de novo synthesis of β-actin localized to the near-side ...
Kin-Mei Leung +5 more
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High level sill and dyke intrusions initiated from rapidly buried mafic lava flows in scoria cones of Tongoa, Vanuatu (New Hebrides), South Pacific [PDF]
, 2006 Scoria cones are generally considered to grow rapidly in days to weeks or months. During their growth lava flows may be fed onto the cone surface from lava-lake breaches, or form by coalescence of spatter; such flows are preserved interbedded with scoria
Nemeth, Karoly, White, James D. L.
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The Role of Apoptotic Signaling in Axon Guidance
Journal of Developmental Biology, 2018 Navigating growth cones are exposed to multiple signals simultaneously and have to integrate competing cues into a coherent navigational response. Integration of guidance cues is traditionally thought to occur at the level of cytoskeletal dynamics ...
Riley Kellermeyer +3 more
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To Stick or Not to Stick: The Multiple Roles of Cell Adhesion Molecules in Neural Circuit Assembly
Frontiers in Neuroscience, 2022 Precise wiring of neural circuits is essential for brain connectivity and function. During development, axons respond to diverse cues present in the extracellular matrix or at the surface of other cells to navigate to specific targets, where they ...
Trevor Moreland, Fabienne E. Poulain
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