Results 11 to 20 of about 96,183 (307)
Functional Redundancy of Cyclase-Associated Proteins CAP1 and CAP2 in Differentiating Neurons
Cells, 2021 Cyclase-associated proteins (CAPs) are evolutionary-conserved actin-binding proteins with crucial functions in regulating actin dynamics, the spatiotemporally controlled assembly and disassembly of actin filaments (F-actin).
Felix Schneider +3 more
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Coactosin Promotes F-Actin Protrusion in Growth Cones Under Cofilin-Related Signaling Pathway
Frontiers in Cell and Developmental Biology, 2021 During brain development, axon outgrowth and its subsequent pathfinding are reliant on a highly motile growth cone located at the tip of the axon. Actin polymerization that is regulated by actin-depolymerizing factors homology (ADF-H) domain-containing ...
Xubin Hou +5 more
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eLife, 2018 A presynaptic adhesion G-protein-coupled receptor, latrophilin-1, and a postsynaptic transmembrane protein, Lasso/teneurin-2, are implicated in trans-synaptic interaction that contributes to synapse formation. Surprisingly, during neuronal development, a
Nickolai V Vysokov +10 more
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An Integrated Cytoskeletal Model of Neurite Outgrowth
Frontiers in Cellular Neuroscience, 2018 Neurite outgrowth underlies the wiring of the nervous system during development and regeneration. Despite a significant body of research, the underlying cytoskeletal mechanics of growth and guidance are not fully understood, and the relative ...
Kyle E. Miller +4 more
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Participation of L-Lactate and Its Receptor HCAR1/GPR81 in Neurovisual Development
Cells, 2021 During the development of the retina and the nervous system, high levels of energy are required by the axons of retinal ganglion cells (RGCs) to grow towards their brain targets.
Samuel Laroche +5 more
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Frontiers in Neuroscience, 2017 The role of mitochondria within injured neurons is an area of active interest since these organelles are vital for the production of cellular energy in the form of ATP.
Wendy M. Knowlton +6 more
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Transcriptional Control of Axon Guidance at Midline Structures
Frontiers in Cell and Developmental Biology, 2022 The development of the nervous system is a time-ordered and multi-stepped process that includes neurogenesis and neuronal specification, axonal navigation, and circuits assembly.
Eloísa Herrera, Augusto Escalante
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Robo2 acts in trans to inhibit Slit-Robo1 repulsion in pre-crossing commissural axons
eLife, 2015 During nervous system development, commissural axons cross the midline despite the presence of repellant ligands. In Drosophila, commissural axons avoid premature responsiveness to the midline repellant Slit by expressing the endosomal sorting receptor ...
Timothy A Evans +3 more
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Growth Cones: Structural, Molecular and Functional Relevance to Neuronal Migration, Regeneration and Reproductive Function [PDF]
Journal of Medical AcademicsThe specialized cells of the human brain form a complex network responsible for neural processing and transmission via various electrochemical signaling pathways.
Mona Sharma, Anmol Garg, Tanya Gupta
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Cue-Polarized Transport of β-actin mRNA Depends on 3′UTR and Microtubules in Live Growth Cones
Frontiers in Cellular Neuroscience, 2018 Guidance cues trigger fast responses in axonal growth cones such as directional turning and collapse that require local protein synthesis. An attractive cue-gradient, such as Netrin-1, triggers de novo synthesis of β-actin localized to the near-side ...
Kin-Mei Leung +5 more
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