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Growth cone motility

Current Opinion in Neurobiology, 1991
The exact nature of growth cone motility is far from understood but progress has been made in several areas. It now appears that growth cones pull and not push; we will review the biophysical basis of growth cone movement. Current ideas on the regulation of growth cone motility and the relationship between motility and axon pathfinding are also ...
S R, Heidemann, R E, Buxbaum
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Growth cone chemotaxis

Trends in Neurosciences, 2008
Wiring up the nervous system depends on the precise guidance of axonal growth cones to their targets. A key mechanism underlying this guidance is chemotaxis, whereby growth cones detect and follow molecular gradients. Although recent work has uncovered many of the molecules involved in this process, the mechanisms underlying chemotactic axon guidance ...
Mortimer, Duncan   +4 more
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Growth cone motility

Current Biology, 1992
Neurons obtain their stereotyped morphologies and connections as a result of growth cone migration. In the past year, studies on growth cone migration and pathfinding have helped to define certain properties of cytoskeletal filaments and cell membranes that may be important in growth cone function.
C, Cypher, P C, Letourneau
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Nerve growth cone motility

Current Opinion in Cell Biology, 1990
Although many issues remain unresolved, the past year has witnessed a number of advances in our understanding of the inter-relationships between extracellular influences, cell phenotype, growth associated proteins, second messengers, and cytoskeletal components in the control of neurite outgrowth and growth cone behavior.
K, Lankford, C, Cypher, P, Letourneau
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Looking into growth cones

Trends in Neurosciences, 1989
The growth cone is a crucial structure in effecting neurite elongation and guiding the neurite onto correct pathways by responding to environmental cues. Recently developed techniques in light and electron microscopy have greatly improved our understanding of the dynamic organization of membrane and cytoskeleton within the growth cone.
D J, Goldberg, D W, Burmeister
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Growth Cone Collapse Assay

2013
Growth cone collapse is an easy and efficient test for detecting and characterizing axon guidance activities secreted or expressed by cells. It can also be used to dissect signaling pathways by axon growth inhibitors and to isolate therapeutic compounds that promote axon regeneration.
Xin, Yue   +2 more
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Growth Cone Motility and Guidance

Annual Review of Cell Biology, 1988
CONTENTS INTRODUCTION 43 SHAPE AND MOVEMENT: What are Growth Cones Really Like? 44 ULTRASTRUCTURE: Evidence of Membrane Recycling .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ... . . . . . . . . . . . 46 COMPOSITION: Do Growth Cone Specific Molecules Exist? ... . . . . . . . .... 47 PHYSIOLOGY: Ionic Signals That Stop a
D, Bray, P J, Hollenbeck
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Growth Cone Collapse Assay

2014
The growth cone collapse assay has proved invaluable in detecting and purifying axonal repellents. Glycoproteins/proteins present in detergent extracts of biological tissues are incorporated into liposomes, added to growth cones in culture and changes in morphology are then assessed.
Geoffrey M W, Cook   +2 more
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Regulation of growth cone motility

Cell Motility, 1991
Nerve growth cones are the motile tips of elongating axons and dendrites. The migration and behavior of growth cones are responsible for axonal pathfinding to synaptic targets, and for the branching patterns of dendritic trees. Growth cones are studied at all levels of organization, molecular, cellular, and within intact embryos. Preparations of growth
P C, Letourneau, C, Cypher
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Driving the Growth Cone

Science, 1998
Growth cones are the specialized tips of neuronal axons that make their way through the nervous system in search of a correct target. In his Perspective, Caroni outlines the signaling mechanisms that help steer the growth cone as it moves, and discusses a report by Song et al .
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