Results 41 to 50 of about 128,440 (289)

Application of Chondroitin Sulfate Derivatives for Understanding Axonal Guidance in the Nervous System during Development [PDF]

, 2013
Neuronal axons and their growth cones recognize molecular guidance cues within the local environment, forming axonal pathways to produce precise neuronal networks during nervous system development.
Ichijo Hiroyuki, Kimata Koji, Sugiura Nobuo   +2 more
core   +3 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

CNP-induced cGMP signaling reduces growth cone stiffness and Ca2+ levels in embryonic DRG neurons

Frontiers in Molecular Neuroscience
A cyclic guanosine monophosphate (cGMP) signaling pathway composed of the extracellular ligand C-type natriuretic peptide (CNP), the transmembrane natriuretic peptide receptor 2 (Npr2), and the cGMP-dependent protein kinase I (cGKI) regulates axon ...
Aylin Balmes, Hannes Schmidt, Stefanie Peters, Selin Kenet, Adelina Botezatu, Lai Wen, Alexandra Böttcher, Peter M. Benz, Peter M. Benz, Robert Feil, Tilman E. Schäffer   +10 more
doaj   +1 more source

High level sill and dyke intrusions initiated from rapidly buried mafic lava flows in scoria cones of Tongoa, Vanuatu (New Hebrides), South Pacific [PDF]

, 2006
Scoria cones are generally considered to grow rapidly in days to weeks or months. During their growth lava flows may be fed onto the cone surface from lava-lake breaches, or form by coalescence of spatter; such flows are preserved interbedded with scoria
Nemeth, Karoly, White, James D. L.
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Revisiting the Proliferated Seed Cones in Larix kaempferi Reveals a Growth Arrest Plasticity

Plant Direct
In angiosperms, such as Arabidopsis, silique removal can reverse developmental arrest and reactivate inflorescence meristems, illustrating that post‐fertilization growth cessation is a plastic process rather than terminal differentiation.
Zha‐Long Ye, Tang‐Quan Liao, Yue Wang, Sheng‐Ying Sun, Shu‐Nong Bai, Xiao‐Mei Sun, Wanfeng Li   +6 more
doaj   +1 more source

The formation of glacier dirt cones

Journal of Glaciology
Glacier dirt cones are meter-scale cones of ice covered with sediment and rock. The cones develop through a process known as differential melt, whereby ice underlying thick debris melts more slowly than bare ice.
Ryan M. Strickland, Matthew D. Covington
doaj   +1 more source

Receptor tyrosine phosphatases regulate axon guidance across the midline of the Drosophila embryo [PDF]

, 2000
Neural receptor-linked protein tyrosine phosphatases (RPTPs) are required for guidance of motoneuron and photoreceptor growth cones in Drosophila. These phosphatases have not been implicated in growth cone responses to specific guidance cues, however, so
Bahri, Sami, Chia, William, Schmid, Aloisia, Sun, Qi, Zinn, Kai   +4 more
core  

Frazzled promotes growth cone attachment at the source of a Netrin gradient in the Drosophila visual system. [PDF]

, 2016
Axon guidance is proposed to act through a combination of long- and short-range attractive and repulsive cues. The ligand-receptor pair, Netrin (Net) and Frazzled (Fra) (DCC, Deleted in Colorectal Cancer, in vertebrates), is recognized as the ...
Akin, Orkun, Zipursky, S Lawrence
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source