Compound loss of GSDMD and GSDME function is necessary to achieve maximal therapeutic effect in colitis [PDF]
Journal of Translational Autoimmunity, 2022 Gasdermin D (GSDMD) and gasdermin E (GSDME) perpetuate inflammation by mediating the release of cytokines such as interleukin-1β (IL-1β) and IL-18. However, not only are the actions of GSDMD in colitis still controversial, but its interplay with GSDME in
Jianqiu Xiao +4 more
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ZNF460 Promotes GSDME-Driven Pyroptosis via PKM2 Transcriptional Activation in Aortic Dissection [PDF]
Reviews in Cardiovascular MedicineBackground: Aortic dissection (AD) is a cardiovascular emergency with high mortality; however, the underlying molecular pathophysiology of AD remains incompletely understood. Pyroptosis, a proinflammatory form of programmed cell death,
Quanlin Yang +8 more
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Frontiers in Cell and Developmental Biology, 2021 GSDME is a newly recognized executor of cellular pyroptosis, and has been recently implicated in tumor growth and immunity. However, knowledge about the molecular regulators underlying GSDME abundance remains limited.
Mei-Chun Cai, Zhuang Yu, Guanglei Zhuang
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Curcumin enhances GSDME-mediated pyroptosis to potentiate PD-1/PD-L1 immune checkpoint blockade in colorectal cancer [PDF]
Frontiers in PharmacologyColorectal cancer (CRC) patients with a microsatellite-stable (MSS) status exhibit poor responsiveness to PD-1/PD-L1 blockade. Pyroptosis induction may resensitize MSS tumors to PD-1/PD-L1 blockade; however, the expression of GSDME, a key executor of ...
Dongsheng Tan +6 more
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Frontiers in Pharmacology, 2022 Gasdermin E (GSDME) is one of the executors of pyroptosis, a type of programmed lytic cell death, which can be triggered by caspase-3 activation upon stimulation.
Da-Xiang Cui
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GSDME in cardiovascular diseases: research system and contemporary progress [PDF]
Frontiers in ImmunologyDespite considerable advancements in treatment technologies in recent years, cardiovascular diseases still pose a significant threat to human health.
Zhenzhen Yang +14 more
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GSDME-dependent pyroptosis drives abdominal aortic aneurysm via promoting vascular senescence [PDF]
Nature CommunicationsSenescence contributes to the pathology of abdominal aortic aneurysm (AAA); however, the regulation of senescence in AAA remains unclear. Here, we sought to determine the role of gasdermin-E (GSDME)-dependent non-canonical pyroptosis in AAA.
Si-Jia Sun +14 more
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Epstein–Barr Virus Silences GSDME and Pyroptosis in Gastric Cancer [PDF]
MicroorganismsEpstein–Barr virus (EBV)-associated gastric carcinoma (EBVaGC) represents a distinct molecular subtype characterized by extensive DNA methylation and altered cell death signaling. This study investigated the regulation and function of gasdermin E (GSDME),
Min-Hyeok Lee +4 more
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Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia [PDF]
Advanced ScienceEarly‐onset preeclampsia (EOPE) is associated with excessive apoptosis and inflammation, but the mechanistic link between these processes remains enigma.
Baoying Huang +15 more
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Nuclear gasdermin E drives endothelin-1-induced metastatic progression independently of the pyroptosis [PDF]
Cell Death and DiseaseElucidation of the molecular mechanism underlying metastatic dissemination in patients with high-grade serous ovarian carcinoma (HG-SOC) has the potential to affect patient outcome.
Celia Roman +6 more
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