Epstein–Barr Virus Silences GSDME and Pyroptosis in Gastric Cancer [PDF]
MicroorganismsEpstein–Barr virus (EBV)-associated gastric carcinoma (EBVaGC) represents a distinct molecular subtype characterized by extensive DNA methylation and altered cell death signaling. This study investigated the regulation and function of gasdermin E (GSDME),
Min-Hyeok Lee +4 more
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GSDME deficiency leads to the aggravation of UVB-induced skin inflammation through enhancing recruitment and activation of neutrophils [PDF]
Cell Death and Disease, 2022 Gasdermin E (GSDME)-mediated pyroptosis is induced in keratinocytes of UVB-challenged skin. The role of GSDME in UVB-caused skin damage remains unknown. To explore the role of GSDME in UVB-induced skin inflammation.
Yujie Chen +10 more
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Renal tubular GSDME protects cisplatin nephrotoxicity by impeding OGT-STAT3-S100A7A axis in male mice [PDF]
Nature CommunicationsGasdermin E (GSDME) is known as a key executive protein of pro-inflammatory pyroptosis. However, the function diversity of GSDME needs further investigation. Here, we show that GSDME expression is downregulated in kidney tissues after cisplatin treatment
Qingzhou Chen +13 more
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Targeting 7KCh-Induced Cell Death Response Mediated by p38, P2X7 and GSDME in Retinal Pigment Epithelium Cells with Sterculic Acid [PDF]
, 2023 Age-related macular degeneration (AMD) is the main cause of blindness in developed countries. AMD is characterized by the formation of drusen, which are lipidic deposits, between retinal pigment epithelium (RPE) and the choroid. One of the main molecules
Ana Pariente +6 more
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Compound loss of GSDMD and GSDME function is necessary to achieve maximal therapeutic effect in colitis [PDF]
Journal of Translational Autoimmunity, 2022 Gasdermin D (GSDMD) and gasdermin E (GSDME) perpetuate inflammation by mediating the release of cytokines such as interleukin-1β (IL-1β) and IL-18. However, not only are the actions of GSDMD in colitis still controversial, but its interplay with GSDME in
Jianqiu Xiao +4 more
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Comprehensive analysis, diagnosis, prognosis, and cordycepin (CD) regulations for GSDME expressions in pan-cancers [PDF]
Cancer Cell InternationalThe Gasdermin E gene (GSDME) plays roles in deafness and cancers. However, the roles and mechanisms in cancers are complex, and the same gene exhibits different mechanisms and actions in different types of cancers.
Jiewen Fu +5 more
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GSDME in cardiovascular diseases: research system and contemporary progress [PDF]
Frontiers in ImmunologyDespite considerable advancements in treatment technologies in recent years, cardiovascular diseases still pose a significant threat to human health.
Zhenzhen Yang +14 more
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GSDME-dependent pyroptosis drives abdominal aortic aneurysm via promoting vascular senescence [PDF]
Nature CommunicationsSenescence contributes to the pathology of abdominal aortic aneurysm (AAA); however, the regulation of senescence in AAA remains unclear. Here, we sought to determine the role of gasdermin-E (GSDME)-dependent non-canonical pyroptosis in AAA.
Si-Jia Sun +14 more
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Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity
Cell Death and Disease, 2021 Chemotherapy drug-induced nephrotoxicity limits clinical applications for treating cancers. Pyroptosis, a newly discovered programmed cell death, was recently reported to be associated with kidney diseases.
Chunhua Weng, Hong Jiang, Jianghua Chen
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Nuclear gasdermin E drives endothelin-1-induced metastatic progression independently of the pyroptosis [PDF]
Cell Death and DiseaseElucidation of the molecular mechanism underlying metastatic dissemination in patients with high-grade serous ovarian carcinoma (HG-SOC) has the potential to affect patient outcome.
Celia Roman +6 more
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