Results 11 to 20 of about 6,248 (265)

Transcription factor Sp1 transcriptionally enhances GSDME expression for pyroptosis

Cell Death and Disease
Gasdermin-E (GSDME), the executioner of pyroptosis when cleaved by caspase 3, plays a crucial role in tumor defense and the response to chemotherapy drugs in cells.
Jiasong Pan, Yuanyuan Li, Wenqing Gao, Qizhou Jiang, Lu Geng, Jin Ding, Suhua Li, Jixi Li   +7 more
doaj   +4 more sources

GSDME-N-induced mitochondrial neurotoxicity in early neurodegeneration was suppressed by nicotine via enhancing autophagic flux [PDF]

Journal of Translational Medicine
Background Neurodegeneration is a chronic, progressive process initiated by early neurite retraction, a pathological hallmark preceding neuronal death in neurodegenerative disorders such as Parkinson’s disease (PD).
Junjun Zhao, Saitao Qiu, Angyang Guo, Haixia Huang, Wei Wang, Jianliang Zhang   +5 more
doaj   +3 more sources

Lenvatinib promotes hepatocellular carcinoma pyroptosis by regulating GSDME palmitoylation

Cancer Biology & Therapy
Lenvatinib, as a multi-kinase inhibitor, has been approved as a first-line drug for patients with advanced hepatocellular carcinoma (HCC). Gasdermin E (GSDME)-mediated pyroptosis, a form of programmed cell death, can be induced by chemotherapy drugs or ...
Yuan Yuan, Mu-Ru Wang, Yang Ding, Ya Lin, Ting-Ting Xu, Xing-Xing He, Pei-Yuan Li   +6 more
doaj   +3 more sources

GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis

Blood Science, 2021
. GSDME contains a pore-forming domain at its N-terminal region to execute pyroptosis. Our previous study has reported that forced expression of Gsdme impairs the reconstitution capacity of hematopoietic stem cells (HSCs).
Xiuxiu Yang, Tingting Cong, Hanqing He, Jianwei Wang   +3 more
doaj   +5 more sources

Epithelial-Mesenchymal Transition Induces GSDME Transcriptional Activation for Inflammatory Pyroptosis [PDF]

Frontiers in Cell and Developmental Biology, 2021
GSDME is a newly recognized executor of cellular pyroptosis, and has been recently implicated in tumor growth and immunity. However, knowledge about the molecular regulators underlying GSDME abundance remains limited.
Chenqiang Jia, Chenqiang Jia, Zhuqing Zhang, Zhuqing Zhang, Jun Tang, Mei-Chun Cai, Jingyu Zang, Kaixuan Shi, Yunheng Sun, Jie Wu, Hailei Shi, Weiping Shi, Pengfei Ma, Xiaojing Zhao, Zhuang Yu, Yujie Fu, Guanglei Zhuang, Guanglei Zhuang   +17 more
doaj   +3 more sources

Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis

Acta Pharmaceutica Sinica B, 2020
Pyroptosis is a form of programmed cell death, and recently described as a new molecular mechanism of chemotherapy drugs in the treatment of tumors. Miltirone, a derivative of phenanthrene-quinone isolated from the root of Salvia miltiorrhiza Bunge, has been shown to possess anti-cancer activities.
Jun Chen
exaly   +5 more sources

Docetaxel induced activation of GSDME pathway and pyroptosis enhance immune lethality in prostate cancer cells. [PDF]

J Exp Clin Cancer Res
Immunotherapy has emerged as a promising approach in prostate cancer treatment, albeit with less efficacy compared to lung and esophageal cancers. Recent studies have explored the combination of chemotherapy, specifically docetaxel, with immunotherapy to
Liu R, Zhang L, Xie G, Li X, Liu Y, Li N, Raveendran A, Feng Y, Lu F, Deng X, Li J, Yang J, Huang Z, Jia Z.   +13 more
europepmc   +3 more sources

GSDME-dependent pyroptosis signaling pathway in diabetic nephropathy

Cell Death Discovery, 2023
Diabetic nephropathy (DN) is one of the serious chronic microvascular complications of diabetes, and leads to the increased morbidity and mortality in diabetic patients.
Shengyu Li, Lifeng Feng, Guangru Li, Ruiqing Liu, Changzhen Ma, Lin Wang, Aijiao Gao, Chang Liu, Yujie Cui, Zecheng Jiang, Yuhang Xie, Qiang Wu, Xia Wang, Liang Yang, Zhi Qi, Yanna Shen   +15 more
doaj   +3 more sources

P06.02.B GSDME-MEDIATED PYROPTOSIS IN GLIOBLASTOMA [PDF]

Neuro-Oncology, 2023
Abstract BACKGROUND Immunotherapeutic strategies have largely failed for glioblastoma , the most frequent primary brain tumor. Beyond apoptosis and autophagy, little is known about cell death mechanisms in glioblastoma, despite their potential impact on the immune microenvironment.
Ege Solel, Egil Brudvik, Sahida Afroz, Ruhul Choudhury, Rolf Bjerkvig, Md. Jakir Hossain, Hrvoje Miletić   +6 more
openalex   +2 more sources

OTUD4-mediated GSDME deubiquitination enhances radiosensitivity in nasopharyngeal carcinoma by inducing pyroptosis

Journal of Experimental & Clinical Cancer Research, 2022
Background Radioresistance is the primary cause of nasopharyngeal carcinoma (NPC) treatment failure. Previous studies have focused on the deficits in cellular apoptosis as a mechanism for radioresistance; however, additional potential death modes ...
Muping Di, Jingjing Miao, Qiuzhong Pan, Zonglong Wu, Boyu Chen, Muru Wang, Jingjing Zhao, Huageng Huang, Jiewen Bai, Qijing Wang, Yan Tang, Yongqiang Li, Jia He, Tong Xiang, Desheng Weng, Lin Wang, Jianchuan Xia, Chong Zhao   +17 more
doaj   +3 more sources