Results 11 to 20 of about 5,144 (202)

GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis

Blood Science, 2021
. GSDME contains a pore-forming domain at its N-terminal region to execute pyroptosis. Our previous study has reported that forced expression of Gsdme impairs the reconstitution capacity of hematopoietic stem cells (HSCs).
Xiuxiu Yang, Tingting Cong, Hanqing He, Jianwei Wang   +3 more
doaj   +5 more sources

GSDME-dependent pyroptosis signaling pathway in diabetic nephropathy

Cell Death Discovery, 2023
Diabetic nephropathy (DN) is one of the serious chronic microvascular complications of diabetes, and leads to the increased morbidity and mortality in diabetic patients.
Shengyu Li, Lifeng Feng, Guangru Li, Ruiqing Liu, Changzhen Ma, Lin Wang, Aijiao Gao, Chang Liu, Yujie Cui, Zecheng Jiang, Yuhang Xie, Qiang Wu, Xia Wang, Liang Yang, Zhi Qi, Yanna Shen   +15 more
doaj   +3 more sources

Transcription factor Sp1 transcriptionally enhances GSDME expression for pyroptosis

Cell Death and Disease
Gasdermin-E (GSDME), the executioner of pyroptosis when cleaved by caspase 3, plays a crucial role in tumor defense and the response to chemotherapy drugs in cells.
Jiasong Pan, Yuanyuan Li, Wenqing Gao, Qizhou Jiang, Lu Geng, Jin Ding, Suhua Li, Jixi Li   +7 more
doaj   +3 more sources

OTUD4-mediated GSDME deubiquitination enhances radiosensitivity in nasopharyngeal carcinoma by inducing pyroptosis

Journal of Experimental & Clinical Cancer Research, 2022
Background Radioresistance is the primary cause of nasopharyngeal carcinoma (NPC) treatment failure. Previous studies have focused on the deficits in cellular apoptosis as a mechanism for radioresistance; however, additional potential death modes ...
Muping Di, Jingjing Miao, Qiuzhong Pan, Zonglong Wu, Boyu Chen, Muru Wang, Jingjing Zhao, Huageng Huang, Jiewen Bai, Qijing Wang, Yan Tang, Yongqiang Li, Jia He, Tong Xiang, Desheng Weng, Lin Wang, Jianchuan Xia, Chong Zhao   +17 more
doaj   +3 more sources

Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity [PDF]

Cell Death and Disease, 2021
Chemotherapy drug-induced nephrotoxicity limits clinical applications for treating cancers. Pyroptosis, a newly discovered programmed cell death, was recently reported to be associated with kidney diseases.
Xiujin Shen, Haibing Wang, Chunhua Weng, Hong Jiang, Jianghua Chen   +4 more
doaj   +3 more sources

Lenvatinib promotes hepatocellular carcinoma pyroptosis by regulating GSDME palmitoylation

Cancer Biology & Therapy
Lenvatinib, as a multi-kinase inhibitor, has been approved as a first-line drug for patients with advanced hepatocellular carcinoma (HCC). Gasdermin E (GSDME)-mediated pyroptosis, a form of programmed cell death, can be induced by chemotherapy drugs or ...
Yuan Yuan, Mu-Ru Wang, Yang Ding, Ya Lin, Ting-Ting Xu, Xing-Xing He, Pei-Yuan Li   +6 more
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Antileukemic effect of venetoclax and hypomethylating agents via caspase-3/GSDME-mediated pyroptosis

Journal of Translational Medicine, 2023
Background The identifying of B-cell lymphoma 2 (Bcl-2) as a therapeutic target has led to a paradigm shift in acute myeloid leukemia (AML) treatment. Pyroptosis is a novel antitumor therapeutic mechanism due to its cytotoxic and immunogenic effects. The
Fanghua Ye, Wen Zhang, Chenying Fan, Jiajia Dong, Min Peng, Wenjun Deng, Hui Zhang, Liangchun Yang   +7 more
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GSDME-N-induced mitochondrial neurotoxicity in early neurodegeneration was suppressed by nicotine via enhancing autophagic flux [PDF]

Journal of Translational Medicine
Background Neurodegeneration is a chronic, progressive process initiated by early neurite retraction, a pathological hallmark preceding neuronal death in neurodegenerative disorders such as Parkinson’s disease (PD).
Junjun Zhao, Saitao Qiu, Angyang Guo, Haixia Huang, Wei Wang, Jianliang Zhang   +5 more
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Cholestane-3β,5α,6β-triol induces cancer cell death by activating GSDME-mediated pyroptosis [PDF]

Frontiers in Pharmacology
BackgroundTrihydroxysterols and their analogues accumulate in several pathologies, including neurodegenerative diseases, cancers, and atherosclerosis.
Jiaxi Chen, Yuan He, Min Zhao, Zihan Liu, Zixin Su, Chuanzhou Li, Chuanzhou Li, Chen Yang, Chen Yang, Jieping Zhang, Shuichun Mao, Hua Han, Zhenyu Cai, Wen Zhang, Wen Zhang   +14 more
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Mini-Review: GSDME-Mediated Pyroptosis in Diabetic Nephropathy [PDF]

Frontiers in Pharmacology, 2021
Pyroptosis is a recently identified type of lytic programmed cell death, in which pores form in the plasma membrane, and cells swell, rupture, and then release their contents, including inflammatory cytokines. Molecular studies indicated that pyroptosis may occur via a gasdermin D (GSDMD) and caspase-1 (Casp1) -dependent classical pathway, a GSDMD and ...
Wen Li, Jing Sun, Xiaoxi Zhou, Yue Lu, Wenpeng Cui, Lining Miao   +5 more
openaire   +3 more sources