Results 31 to 40 of about 6,248 (265)

The Role and Mechanism of GSDME-Dependent Pyroptosis in Cochlear Marginal Cells Injury by Cisplatin

Biomedicines
Background: Elucidating the mechanisms underlying cisplatin-induced ototoxicity is critical for the clinical management of hearing loss. While cisplatin is known to penetrate the inner ear via the blood-labyrinth barrier in the stria vascularis, its ...
Wenyang Lei, Wenting Yu, Ting Li, Wei Tang, Shimin Zong, Hongjun Xiao   +5 more
doaj   +2 more sources

GSDME unlocks astrocyte-driven neurotoxicity in Alzheimer’s Disease [PDF]

SUMMARY Astrocytic calcium dysregulation and reactivity precede Aβ deposition in amyloid-β deposition in Alzheimer’s disease (AD) but the neurotoxic mechanisms remain unclear. We show that GSDME acts as a switch, linking MAM-mediated calcium release to astrocyte-driven neurotoxicity.
Xueman Xie, Chenhui Ji, Jingmei Xu, Xiaoyang Lu, Ge Guo, Wenjing Liu, Xiaoming Wu, Yaozhen Chen, Yuanxing Zhang, Jintao Wang, Jianping Li, Xingbin Hu, Shouwen Chen, Gang Wang, Qin Liu   +14 more
openalex   +2 more sources

Pyroptosis in Peripheral Neuropathy: From Molecular Mechanisms to Therapeutic Targeting. [PDF]

CNS Neurosci Ther
Pyroptosis is a key inflammatory cell death pathway in peripheral neuropathy, with opposing roles: it perpetuates neuropathic pain but can be induced to kill neuroblastoma cells. This review consolidates mechanistic understanding and therapeutic strategies, arguing for a shift from disease‐centric to target‐centric treatment approaches to improve ...
Wei J, Liuyuan M, Ye Z, Wang X, Zhou X, Shan Y, He C, Zhu C, Zhou C, Bao J, Zhang Y, Chen G.   +11 more
europepmc   +2 more sources

Gasdermin-E Mediated Pyroptosis—A Novel Mechanism Regulating Migration, Invasion and Release of Inflammatory Cytokines in Rheumatoid Arthritis Fibroblast-like Synoviocytes

Frontiers in Cell and Developmental Biology, 2022
Synovium fibroblast-like synoviocytes (FLSs) are important participants in the pathogenesis of synovitis and joint destruction in rheumatoid arthritis (RA).
Tao Wu, Xue-Pei Zhang, Qian Zhang, Yao-Yao Zou, Jian-Da Ma, Le-Feng Chen, Yao-Wei Zou, Ji-Meng Xue, Ruo-Fan Ma, Zhong Chen, Lie Dai   +10 more
doaj   +1 more source

Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation

Cell Death and Disease, 2021
Pyroptosis, one kind of inflammatory regulated cell death, is involved in various inflammatory diseases, including acute kidney injury (AKI). Besides Gasdermin D (GSDMD), GSDME is a newly identified mediator of pyroptosis via the cleavage of caspase-3 ...
Weiwei Xia, Yuanyuan Li, Mengying Wu, Qianqian Jin, Qian Wang, Shuzhen Li, Songming Huang, Aihua Zhang, Yue Zhang, Zhanjun Jia   +9 more
doaj   +1 more source

Roll with the punches: Fibroblast growth factor 10 alleviates pyroptosis of alveolar epithelial cells in different immune niches. [PDF]

Clin Transl Med
Our study reveals a marked decrease of serum FGF10 levels in ARDS patients, correlating with P/F ratio, hospitalisation days and mortality rates. We clarify how FGF10 prevents AECs' pyroptosis triggered by different immune cell infiltrations in different ways.
Wei T, Chen X, Xu J, Mao W, Yang Z, Wang Y, Li Y, Jin W, Chen C, Zhang C, Song Y.   +10 more
europepmc   +2 more sources

BECN1 modulates hematopoietic stem cells by targeting Caspase-3-GSDME-mediated pyroptosis

Blood Science, 2020
Abstract Hematopoietic stem cells (HSCs) maintain the blood system throughout the lifespan. However, the molecular mechanism maintaining HSC character remains not fully understood. In this study, we observed that the targeted deletion of Becn1 disrupts the blood system and impairs the reconstitution capacity of HSCs ...
Xiuxiu Yang, Liang Ge, Jianwei Wang
openalex   +4 more sources

NET formation is a default epigenetic program controlled by PAD4 in apoptotic neutrophils. [PDF]

, 2023
Neutrophil extracellular traps (NETs) not only counteract bacterial and fungal pathogens but can also promote thrombosis, autoimmunity, and sterile inflammation. The presence of citrullinated histones, generated by the peptidylarginine deiminase 4 (PAD4),
Amatullah, Hajera, Askari, Kasra, Catz, Sergio, Chen, Alyce, Croker, Ben, Gerlic, Motti, Ghassemian, Majid, Greco, Kimberly, Griffis, Eric, Hoffman, Hal, Huang, Carolyn, Jeffrey, Kate, Kiosses, William, Lee, Jamie, Nowell, Cameron, Peng, Weiqi, Sadreyev, Ruslan, Salinger, Ari, Santini, Jennifer, Speir, Mary, Tan, ZheHao, Thompson, Paul, Weller, Edie, Wong, Lai, Wu, Gio, Zhu, Yanfang   +25 more
core   +1 more source

Gasdermin-E-mediated pyroptosis participates in the pathogenesis of Crohn’s disease by promoting intestinal inflammation

Cell Reports, 2021
Summary: Crohn’s disease (CD) is a kind of refractory intestinal inflammatory diseases. Pyroptosis was recently identified as a gasdermin-mediated proinflammatory cell death.
Gao Tan, Chongyang Huang, Jiaye Chen, Bingxia Chen, Fachao Zhi   +4 more
doaj   +1 more source

ER stress induces caspase-2-tBID-GSDME-dependent cell death in neurons lytically infected with herpes simplex virus type 2 [PDF]

, 2023
Neurotropic viruses, including herpes simplex virus (HSV) types 1 and 2, have the capacity to infect neurons and can cause severe diseases. This is associated with neuronal cell death, which may contribute to morbidity or even mortality if the infection ...
Bak, Rasmus O., Fruhwürth, Stefanie, Gao, Zongliang, Narita, Ryo, Paludan, Søren R., Rashidi, Ahmad S., Reinert, Line S., Ren, Fanghui, Thomsen, Martin K., Verjans, Georges M.G.M.   +9 more
core   +2 more sources