Results 31 to 40 of about 5,144 (202)
Biomedicines, 2023 The initiation of atherosclerotic plaque is characterized by endothelial cell inflammation. In light of gasdermin E’s (GSDME) role in pyroptosis and inflammation, this study elucidates its function in atherosclerosis onset.
Shiyao Xie +7 more
doaj +1 more source
Viral sensing by epithelial cells involves PKR- and caspase-3-dependent generation of gasdermin E pores [PDF]
, 2023 Viral sensing in myeloid cells involves inflammasome activation leading to gasdermin pore formation, cytokine release, and cell death. However, less is known about viral sensing in barrier epithelial cells, which are critical to the innate immune ...
Baran, Marcin +4 more
core +2 more sources
Recombinant DnaK orally administered protects axenic European sea bass against vibriosis [PDF]
, 2020 Vibrio anguillarum causes high mortality in European sea bass (Dicentrarchus labrax) larviculture and is a hindering factor for successful sustainable aquaculture of this commercially valuable species.
Bajek, Aline +6 more
core +2 more sources
CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma [PDF]
, 2022 Therapy resistance, which leads to the development of loco-regional relapses and distant metastases after treatment, constitutes one of the major problems that head and neck squamous cell carcinoma (HNSCC) patients currently face. Thus, novel therapeutic
Alba-Castellón, Lorena +13 more
core +1 more source
The multifaceted roles of gasdermins in cancer biology and oncologic therapies [PDF]
, 2021 The involvement of the Gasdermin (GSDM) protein family in cancer and other pathologies is one of the hottest topics in biomedical research. There are six GSDMs in humans (GSDMA, B, C, D, GSDME/DFNA5 and PJVK/ DFNB59) and, except PJVK, they can trigger ...
Martinez-Val, Jeannette +4 more
core +1 more source
Gasdermin E: A Prospective Target for Therapy of Diseases
Frontiers in Pharmacology, 2022 Gasdermin E (GSDME) is a member of the gasdermin protein family, which mediates programmed cell death including apoptosis and pyroptosis. Recently, it was suggested that GSDME is activated by chemotherapeutic drugs to stimulate pyroptosis of cancer cells
Xiu-Xiu Liao +3 more
doaj +1 more source
The Antitriple Negative Breast cancer Efficacy of Spatholobus suberectus Dunn on ROS-Induced Noncanonical Inflammasome Pyroptotic Pathway [PDF]
, 2021 Breast cancer (BCa) is the leading cause of women’s death worldwide; among them, triple-negative breast cancer (TNBC) is one of the most troublesome subtypes with easy recurrence and great aggressive properties.
Chen, J +7 more
core +1 more source
Cell Death Discovery, 2022 An increase in apoptosis and/or defects in the clearance of apoptotic cells resulting in massive secondary necrosis have been recognized as the main causes of systemic lupus erythematosus (SLE).
Guihu Luo +13 more
doaj +1 more source
Cells, 2023 Psoriasis is a frequent and incurable skin disease whose pathogenesis is still not fully understood. It is characterized by immune disturbances leading to hyperproliferation and improper differentiation of keratinocytes.
Julia Nowowiejska +6 more
doaj +1 more source
Caspase-8 activation by cigarette smoke induces pro-inflammatory cell death of human macrophages exposed to lipopolysaccharide [PDF]
, 2023 Cigarette smoking impairs the lung innate immune response making smokers more susceptible to infections and severe symptoms. Dysregulation of cell death is emerging as a key player in chronic inflammatory conditions.
Amato S. +16 more
core +1 more source