Results 61 to 70 of about 6,248 (265)
Induction of pyroptotic cell death as a potential tool for cancer treatment [PDF]
, 2022 Cancer is a complex pathological disease and the existing strategies for introducing chemotherapeutic agents have restricted potential due to a lack of cancer cell targeting specificity, cytotoxicity, bioavailability, and induction of multi-drug ...
Cordeiro de Lima, Vladmir Claudio +5 more
core +1 more source
Frontiers in Pharmacology, 2022 Gasdermin E (GSDME) is one of the executors of pyroptosis, a type of programmed lytic cell death, which can be triggered by caspase-3 activation upon stimulation.
Ying Xia +12 more
doaj +1 more source
Pyroptotic and Necroptotic Cell Death in the Tumor Microenvironment and Their Potential to Stimulate Anti-Tumor Immune Responses [PDF]
, 2023 Cancer remains the second most common cause of death worldwide affecting around 10 million patients every year. Among the therapeutic options, chemotherapeutic drugs are widely used but often associated with side effects.
Adriouch, Sahil +4 more
core +1 more source
Gasdermin D-deficient mice are hypersensitive to acute kidney injury [PDF]
, 2022 Signaling pathways of regulated necrosis, such as necroptosis and ferroptosis, contribute to acute kidney injury (AKI), but the role of pyroptosis is unclear. Pyroptosis is mediated by the pore-forming protein gasdermin D (GSDMD).
Anders, Hans-Joachim +17 more
core +1 more source
The new world of RNA diagnostics and therapeutics [PDF]
, 2023 The 5th Workshop IRE on Translational Oncology was held in Rome (Italy) on 27–28 March at the IRCCS Regina Elena National Cancer Institute. This meeting entitled “The New World of RNA diagnostics and therapeutics” highlightes the significant progress in ...
Alina Catalina Palcau +18 more
core +4 more sources
Acta Pharmaceutica Sinica B, 2023 It is discovered that activated caspase-3 tends to induce apoptosis in gasdermin E (GSDME)-deficient cells, but pyroptosis in GSDME-sufficient cells. The high GSDME expression and apoptosis resistance of pancreatic ductal adenocarcinoma (PDAC) cells shed
Yang Liu +7 more
doaj +1 more source
Fracture healing is delayed in the absence of gasdermin-interleukin-1 signaling [PDF]
, 2022 Amino-terminal fragments from proteolytically cleaved gasdermins (GSDMs) form plasma membrane pores that enable the secretion of interleukin-1β (IL-1β) and IL-18.
Abu-Amer, Yousef +12 more
core +2 more sources
Activation of GSDME by Lithospermum erythrorhizon drives pyroptotic cell death
Journal of Traditional Chinese Medical Sciences, 2023 Objective: To reveal GSDME-executed pyroptosis in cancer cells induced by the Chinese traditional herbal medicine plant Lithospermum erythrorhizon (L. erythrorhizon, Zi Cao) and to investigate the potential mechanism. Methods: L. erythrorhizon was extracted by ultrasonication in 95% ethanol, and determined using high-performance liquid chromatography ...
Sanjiao Wang +7 more
openaire +2 more sources
Fosinopril mediates antitumor efficacy by inducing GSDME-dependent pyroptosis in NSCLC. [PDF]
Cell Death DiscovRepurposing existing drugs offers a promising approach to cancer therapy. Fosinopril, an angiotensin converting enzyme inhibitor (ACEI) approved for hypertension, has demonstrated antitumor effects in hepatocellular carcinoma.
Gao Y +10 more
europepmc +2 more sources
NLRP3 Selectively Drives IL-1β Secretion by Pseudomonas aeruginosa Infected Neutrophils and Regulates Corneal Disease Severity [PDF]
, 2023 Macrophages infected with Gram-negative bacteria expressing Type III secretion system (T3SS) activate the NLRC4 inflammasome, resulting in Gasdermin D (GSDMD)-dependent, but GSDME independent IL-1β secretion and pyroptosis.
Abbondante, Serena +10 more
core +1 more source