Results 101 to 110 of about 15,901 (303)

A targeted antiferromagnetic nanoprobe for ultra‐sensitive magnetic resonance imaging detection of sub‐millimeter esophageal tumors

BMEMat, EarlyView.
We developed a cyclo‐RGD peptide‐conjugated antiferromagnetic nanoparticle (RANP) as a targeted T1 contrast agent. Under 9 T MRI conditions, RANP exhibited an r1 value of 1.88 mM−1 s−1 and a low r2/r1 ratio of 1.84, enabling the detection of esophageal tumors as small as 0.8 mm in vivo. Abstract Early, non‐invasive detection of esophageal cancer at sub‐
Wenkui Mo, Zeyu Liang, Bo Zhang, Lin Xiao, Xun Liu, Zhigao Yi, Shangzhi Xie, Qiyue Wang, Liang Shi, Taobo Luo, Feng Li, Leilei Wu, Yuanzhe Piao, Fangyuan Li, Jian Zeng, Daishun Ling   +15 more
wiley   +1 more source

Triggering and Preventing Cyclization of o-Amino-Guanidinobenzenes to 2-Amino-Benzimidazoles. [PDF]

Chemistry
o‐Amino‐guanidinobenzenes are generally prone to cyclization to 2‐amino‐benzimidazoles. In this work, strategies to prevent such cyclizations are developed, allowing to use these compounds as ligands in coordination chemistry and for the design of novel (unsymmetrical) redox‐active ligands.
Henel CLM, Michel E, Zeitler D, Hübner O, Kaifer E, Himmel HJ.   +5 more
europepmc   +2 more sources

Asymmetric Total Synthesis of (+)‐Merobatzelladine B [PDF]

, 2012
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91220/1/ange_201201001_sm_miscellaneous_information.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/91220/2/4204_ftp ...
Arnold, Aron, Berlinck, Berlinck, Berlinck, Bertrand, Bertrand, Bewley, Butters, Cohen, Davis, Davis, Evans, Fritz, Fritz, Ishiwata, Leathen, Murphy, Nakhla, Nakhla, Neukom, Neukom, Overman, Patil, Schultz, Snider, Snider, Takishima, Takishima, Tang, Wolfe   +30 more
core   +1 more source

Easier, Safer, and Greener: Unlocking the Power of Solid Reagents in Organic Reactions by Mechanochemistry

ChemistryEurope, EarlyView.
This review highlights the powerful synergy between mechanochemistry and solid reagents to replace hazardous substances traditionally used in organic synthesis. Such an approach offers a safer and more sustainable pathway for conducting organic reactions, with potential benefits in both reactivity and selectivity. The use of solid bases, acids, and gas
Adrien Gallego, Nicolas Pétry, Julien Pinaud, Olivia Giani, Frédéric Lamaty   +4 more
wiley   +1 more source

Structure‐Activity Relationship of Hetarylpropylguanidines Aiming at the Development of Selective Histamine Receptor Ligands†

ChemistryOpen, 2019
New classes of alkylated hetarylpropylguanidines with different functionality and variation in spacer length were synthesized to determine their behavior at the four histamine receptor (H1R, H2R, H3R, H4R) subtypes.
Dr. Steffen Pockes, Dr. David Wifling, Prof. Dr. Armin Buschauer, Prof. Dr. Sigurd Elz   +3 more
doaj   +1 more source

Alkaline earth complexes of a sterically demanding guanidinate ligand [PDF]

, 2015
The synthesis of the guanidine MesN{C(NCy2)}N(H)Mes (LH; Mes = 2,4,6-Me3C6H2, Cy = cyclohexyl), and its use as a proligand for the synthesis of alkaline earth metal complexes are reported.
Blake, Alexander J., Kays, Deborah L., Lewis, William, Moxey, Graeme J.   +3 more
core   +1 more source

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source

Ptilomycalin A, crambescidin 800 and related new highly cytotoxic guanidine alkaloids from the starfishes Fromia monilis and Celerina heffernani [PDF]

, 1995
Two novel pentacyclic guanidine alkaloids, celeromycalin 3 and fromiamycalin 4, have been isolated from the New Caledonian starfishes Celerina heffernani and Fromia monilis, respectively.
Carré, Jean-Baptiste, De Marino, S., Debitus, Cécile, Iorizzi, M., Lucarain, L., Minale, L., Palagiano, E., Provost, J., Riccio, R., Zollo, F.   +9 more
core   +1 more source

Uncovering the role of genetic polymorphisms in cervical insufficiency

International Journal of Gynecology &Obstetrics, EarlyView.
Pathways and genes implicated in CI pathogenesis. Abstract Cervical insufficiency (CI) is characterized by spontaneous dilation of the cervix in the absence of painful uterine contractions in the mid‐trimester, leading to premature delivery. It is responsible for up to 20% of second trimester pregnancy losses, mostly <24 weeks.
Kallirhoe Kalinderi, Michail Kalinderis, Maria Chatzidimitriou, Liana Fidani   +3 more
wiley   +1 more source

Integrative Genomics Reveals Causal Pleiotropy and Therapeutic Opportunities at the Interface of Acute Pancreatitis and Infection

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Understanding the genetic links between acute pancreatitis (AP) and its infectious comorbidities is crucial for prognosis and therapy, yet remains underexplored. Methods We conducted a comprehensive post‐GWAS analysis using large‐scale summary statistics for AP and 16 infectious diseases. To pinpoint pleiotropic genes, we integrated
Bo Zou, Hao Jiang, Jingsheng Ruan, Daifeng Yang, Xing Chen, Shanshan Cai, Xinglin Yi   +6 more
wiley   +1 more source