Results 61 to 70 of about 24,574 (211)

Effects of a Mutation in the gyrA Gene on the Virulence of Uropathogenic Escherichia coli [PDF]

Antimicrobial Agents and Chemotherapy, 2015
ABSTRACT Fluoroquinolones are among the drugs most extensively used for the treatment of bacterial infections in human and veterinary medicine. Resistance to quinolones can be chromosome or plasmid mediated. The chromosomal mechanism of resistance is associated with mutations in the DNA gyrase- and topoisomerase IV-encoding genes
Sánchez Céspedes, Javier, Sáez-López, Emma, Frimodt-Mφller, N., Soto González, Sara M., Vila Estapé, Jordi   +4 more
openaire   +3 more sources

Co-Incidence of Type II Topoisomerase Mutations and Efflux Expression in High Fluoroquinolone Resistant Enterococcus faecalis Isolated from Urinary Tract Infections

Infection and Drug Resistance, 2020
Sarvenaz Esfahani, Roya Ahmadrajabi, Hamidreza Mollaei, Fereshteh Saffari Department of Microbiology and Virology, School of Medicine, Kerman University of Medical Sciences, Kerman, IranCorrespondence: Fereshteh Saffari Email fsafari@kmu.ac ...
Esfahani S, Ahmadrajabi R, Mollaei H, Saffari F   +3 more
doaj  

Manure Composting as a Strategy to Mitigate Antibiotic Resistance Dissemination in Agricultural Systems

Land Degradation &Development, EarlyView.
ABSTRACT Livestock manure is a valuable agricultural resource but may introduce antibiotic residues and antibiotic resistance genes (ARGs) into the environment. This review critically evaluates the fate of antibiotics and ARGs during manure composting and identifies the principal factors controlling their attenuation.
Magdalena Urbaniak
wiley   +1 more source

Competitions experiments and gyrA mutations

, 2016
In this file, you can find: tab 1) legend for tables, tab 2) raw data of fluorescence from competition experiments and estimations of selection coefficients, tab 3) mutations detected in the gyrA gene associated with each mutant, tab 4) raw data for ...
Lenormand, Thomas, Thomas Lenormand (58424), Harmand, Noémie, Roula Jabbour-Zahab (181492), Romain Gallet (846744), Martin, Guillaume, Gallet, Romain, Noémie Harmand (3332349), Guillaume Martin (428418), Jabbour-Zahab, Roula   +9 more
core   +1 more source

Supercoil Levels in E. coli and Salmonella Chromosomes Are Regulated by the C-Terminal 35–38 Amino Acids of GyrA

Microorganisms, 2019
Prokaryotes have an essential gene—gyrase—that catalyzes negative supercoiling of plasmid and chromosomal DNA. Negative supercoils influence DNA replication, transcription, homologous recombination, site-specific recombination, genetic ...
Nikolay S. Rovinskiy, Andrews A. Agbleke, Olga N. Chesnokova, N. Patrick Higgins   +3 more
doaj   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Investigating the Roles of the C-Terminal Domain of Plasmodium falciparum GyrA

PLOS ONE, 2015
Malaria remains as one of the most deadly diseases in developing countries. The Plasmodium causative agents of human malaria such as Plasmodium falciparum possess an organelle, the apicoplast, which is the result of secondary endosymbiosis and retains its own circular DNA. A type II topoisomerase, DNA gyrase, is present in the apicoplast.
Nagano, Soshichiro, Seki, Eiko, Lin, Ting-Yu, Shirouzu, Mikako, Yokoyama, Shigeyuki, Heddle, Jonathan   +5 more
openaire   +5 more sources

Phenotypic Florfenicol Resistance in floR‐Harbouring Flavobacterium psychrophilum Isolates (CC‐ST90): A Case Study From Danish Freshwater Rainbow Trout Aquaculture

Journal of Fish Diseases, EarlyView.
ABSTRACT Monitoring antimicrobial resistance (AMR) in fish pathogens is essential for supporting sustainable aquaculture. In this study, susceptibility testing and genome sequencing were used to characterize the AMR profile of seven Flavobacterium psychrophilum originating from Danish rainbow trout farms (2019–2022).
Valentina L. Donati, Lone Madsen
wiley   +1 more source

The Role of DNA Gyrase (gyrA) in Ciprofloxacin-Resistant Locally Isolates Pseudomonas aeruginosa in Al-Khadhmiya Teaching Hospital Baghdad, Iraq

, 2019
Ciprofloxacin comprise a medically effective and generally utilized class of broad-spectrum antibiotics; as a result of the intensive use of this type of therapy, bacteria have become resistant, lead to minimize the usage of such bactericides in field of
Montaha A. Al-Safar, Jabbar S. Hassan, Thanaa Rasheed Abdul Rhman   +2 more
core   +1 more source

Prevalence of the gyrA T86I mutation.

, 2020
Prevalence of the gyrA T86I mutation.
Carmen Martinez-Rodriguez (8379126), Christina Bronowski (485242), Jane Pulman (3582440), Sam Haldenby (251500), Frederick J. Bolton (8379138), Nicola J. Williams (6904322), Roy Chaudhuri (480357), Sarah J. O’Brien (8379141), Neil Hall (12782), Tom J. Humphrey (4633897), Craig Winstanley (75404), Ken Forbes (3247587), Christiane Hertz-Fowler (243178), Ian N. Winstanley (8379132), Charlotte Nelson (370643), John Kenny (411162), Norval J. Strachan (8379129), Caroline E. Corless (8379135)   +17 more
core   +1 more source