Results 11 to 20 of about 14,513 (135)

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis. [PDF]

Adv Sci (Weinh)
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Fries F, Herrmann J, Dal Molin M, Wormser Y, Risch T, Gao Y, Prosser G, Gubellini F, Mechaly A, Wallach JB, Castro A, Banerjee A, Rasheed S, Horn A, Müsken M, Kurz M, Sonnenkalb L, Dreyer V, Niemann S, Andres S, Schnappinger D, Kazmaier U, Reiling N, Müller R, Rybniker J, Petrella S.   +25 more
europepmc   +2 more sources

Combating Campylobacter Resistance in Moroccan Poultry Using Essential Oil-Ciprofloxacin Combination. [PDF]

Vet Med Sci
With an estimated prevalence of 15.52% in Moroccan poultry, Campylobacter species pose a significant food safety concern. We investigated whether essential oils (EOs) could restore the efficacy of ciprofloxacin against multidrug‐resistant (MDR) strains.
Soubai Z, Ziyate N, Rais R, Elhrech H, Aguerd O, Bouyahya A, Benali T, Akhazzane M, Mahir H, Fellahi S, Al Abdulmonem W, Houssni IE, Attarassi B, Auajjar N.   +13 more
europepmc   +2 more sources

Metagenomic Characterisation of Antibiotic Resistance in Anaerobic Digesters and Their Implications for Environmental Health. [PDF]

Environ Microbiol Rep
Anaerobic digester metagenomes revealed diverse resistance‐associated annotations and antibiotic target loci, highlighting their potential role in environmental AMR surveillance. The findings emphasise the need for cautious interpretation of resistome profiles and further host‐resolved analyses to determine the mobility and clinical relevance of ...
Olasupo OA, Olaniyan OP, Akinde SB, Adesoye AA, Ajadi FA, Obire O, Oladipo EK, Sule WF, Oyinloye OE, Salami AA, Fajoyegbe ES, Ajani AJ, Ojo O.   +12 more
europepmc   +2 more sources

Molecular Characterization of Fluoroquinolone-Resistant Bartonella bacilliformis

Pathogens, 2021
The presence of amino acid changes in GyrA, GyrB, ParC, ParE, and in a proposed chromosomal chloramphenicol acetyl transferase (CAT), as well as mutations at 23S rRNA, were established by PCR and sequencing in 38 B.
Giovanna Mendoza-Mujica, Diana Flores-León, Joaquim Ruiz   +2 more
doaj   +1 more source

Molecular basis of ciprofloxacin (fluoroquinolone)-resistant in clinical isolates of Escherichia coli

Zanco Journal of Pure and Applied Sciences, 2020
It has recently been shown that antibiotic resistance is considered as one of the extremely imperative worrisome in medicine, with tremendously resistant pathogens of numerous species of bacteria demonstrating difficult to treat.
Ahmed Mohammed Tofiq
doaj   +1 more source

Deciphering intra-species bacterial diversity of meat and seafood spoilage microbiota using gyrB amplicon sequencing: A comparative analysis with 16S rDNA V3-V4 amplicon sequencing. [PDF]

PLoS ONE, 2018
Meat and seafood spoilage ecosystems harbor extensive bacterial genomic diversity that is mainly found within a small number of species but within a large number of strains with different spoilage metabolic potential.
Simon Poirier, Olivier Rué, Raphaëlle Peguilhan, Gwendoline Coeuret, Monique Zagorec, Marie-Christine Champomier-Vergès, Valentin Loux, Stéphane Chaillou   +7 more
doaj   +1 more source

First report of Pseudomonas marginalis causing tuber soft rot of potato in Iran [PDF]

Journal of Plant Protection Research
In 2016, potato tuber soft rot symptoms were observed in major potato production fields in Jiroft county (southern Kerman province, Iran). Bacteria, which appeared as white to creamy colonies, were isolated from diseased tissues and shown to be ...
Simin Ghasemi, Pejman Khodaygan, Srđan G Aćimović, Esmaeil Basavand   +3 more
doaj   +1 more source

Discovery of N-quinazolinone-4-hydroxy-2-quinolone-3-carboxamides as DNA gyrase B-targeted antibacterial agents

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Emerging drug resistance is generating an urgent need for novel and effective antibiotics. A promising target that has not yet been addressed by approved antibiotics is the bacterial DNA gyrase subunit B (GyrB), and GyrB inhibitors could be effective ...
Wenjie Xue, Yaling Wang, Xu Lian, Xueyao Li, Jing Pang, Johannes Kirchmair, Kebin Wu, Zunsheng Han, Xuefu You, Hongmin Zhang, Jie Xia, Song Wu   +11 more
doaj   +1 more source

Acinetobacter Strain KUO11TH, a Unique Organism Related to Acinetobacter pittii and Isolated from the Skin Mucus of Healthy Bighead Catfish and Its Efficacy Against Several Fish Pathogens

Microorganisms, 2019
The bacterial strain KU011TH was isolated from the skin mucus of healthy bighead catfish. The strain is a Gram-negative coccobacillus that is nonmotile, aerobic, catalase positive, oxidase negative, and nonhemolytic. Sequence analyses of the housekeeping
Anurak Bunnoy, Uthairat Na-Nakorn, Pattanapon Kayansamruaj, Prapansak Srisapoome   +3 more
doaj   +1 more source

In Silico Screening of DNA Gyrase B Potent Flavonoids for the Treatment of Clostridium difficile Infection from PhytoHub Database [PDF]

Brazilian Archives of Biology and Technology, 2021
Clostridium difficile infection (CDI) is the most common hospital acquired diarrheal disease with its increasing incidence and mortality rate globally.
Kanika Verma, Panupong Mahalapbutr, Utid Suriya, Tuanjai Somboon, Thitinan Aiebchun, Liyi Shi, Phornphimon Maitarad, Thanyada Rungrotmongkol   +7 more
doaj   +1 more source