Results 1 to 10 of about 24,574 (211)

Molecular Evolution of the Pseudomonas aeruginosa DNA Gyrase gyrA Gene

Microorganisms, 2022
DNA gyrase plays important roles in genome replication in various bacteria, including Pseudomonasaeruginosa. The gyrA gene encodes the gyrase subunit A protein (GyrA). Mutations in GyrA are associated with resistance to quinolone-based antibiotics.
Mitsuru Sada, Hirokazu Kimura, Norika Nagasawa, Mao Akagawa, Kaori Okayama, Tatsuya Shirai, Soyoka Sunagawa, Ryusuke Kimura, Takeshi Saraya, Haruyuki Ishii, Daisuke Kurai, Takeshi Tsugawa, Atsuyoshi Nishina, Haruyoshi Tomita, Mitsuaki Okodo, Shinichiro Hirai, Akihide Ryo, Taisei Ishioka, Koichi Murakami   +18 more
doaj   +4 more sources

Stepwise evolution and clonal enrichment of gepotidacin resistance in Neisseria gonorrhoeae [PDF]

Antimicrobial Agents and Chemotherapy
Although gepotidacin is a promising oral candidate for treating multidrug-resistant Neisseria gonorrhoeae, its resistance mechanisms and clinical implications remain poorly understood. In this study, we collected 989 clinical N. gonorrhoeae isolates from
Linxin Yao, Tingli Tian, Danyang Zou, Xinying Lu, Nanyan Jiang, Xin Feng, Tong Zheng, Zhuojun Tang, Yi Lin, Zhen Ning, Jianping Jiang, Meiping Ye, Pingyu Zhou   +12 more
doaj   +2 more sources

Computational Screening of Selected Phytochemicals Against Levofloxacin and Metronidazole-Resistant Indonesian H. pylori Strains [PDF]

Microorganisms
The incidence of levofloxacin and metronidazole resistance in H. pylori Indonesian strains is increasing. Conventional approaches to antibacterial discovery are often a protracted process.
Musa Ghufron, Sukardiman Sukardiman, Muhammad Miftahussurur   +2 more
doaj   +2 more sources

Survey of Oxolinic Acid-Resistant Erwinia amylovora in Korean Apple and Pear Orchards, and the Fitness Impact of Constructed Mutants [PDF]

The Plant Pathology Journal, 2022
Fire blight caused by Erwinia amylovora (Ea) is a devastating disease in apple and pear trees. Oxolinic acid (OA), a quinolone family antibiotic that inhibits DNA gyrase, has been employed to control fire blight in South Korea since 2015.
Hyeonheui Ham, Ga-Ram Oh, Dong Suk Park, Yong Hoon Lee   +3 more
doaj   +1 more source

Identification of two novel type II topoisomerase mutations in Enterococcus spp. isolated from a hospital in China [PDF]

Archives of Biological Sciences, 2021
Type II topoisomerases, including DNA gyrase (GyrA) and topoisomerase IV (ParC), contribute to fluoroquinolone resistance in Enterococcus spp. This study investigated the mutational status of the quinolone resistance-determining regions (QRDRs) of GyrA ...
Su Rina, Peng Yunzhi, Wang Zhanli, Yu Hui, Wu Qi   +4 more
doaj   +1 more source

Mutation of Gyra Gene Found In Mycobacterium Leprae From Leprosy Patient In West Papua and Papua, Indonesia

Indonesian Journal of Pharmacy, 2021
Cases of leprosy in Indonesia are still high, especially in the provinces of West Papua, North Maluku and Papua. Drug resistance surveillance and typing strains of Mycobacterium leprae are useful molecular tools for leprosy control especially in the ...
Yustinus Maladan, Hana Krismawati, Rosana Agus, Hotma M.L. Hutapea, Ratna Tanjung, Vatim Dwi Cahyani, Muhammad Fajri Rokhmad, Arli Aditya Parikesit   +7 more
doaj   +1 more source

Genetic polymorphism and phenotypic resistance of Mycobacterium tuberculosis to ofloxacin and moxifloxacin

Туберкулез и болезни лёгких, 2020
The objective: to study the phenotypic sensitivity of Mycobacterium tuberculosis (MTB) to fluoroquinolones, ofloxacin and moxifloxacin and correlate it with MTB genome mutations associated with resistance to fluoroquinolones to determine the possibility ...
D. V. Vаkhrushevа, T. V. Umpelevа, N. I. Eremeevа, L. S. Lаvrenchuk, S. Yu. Krаsnoborovа, А. E. Panova   +5 more
doaj   +1 more source

Ofloxacin resistance in Mycobacterium tuberculosis: An increasing concern

Indian Journal of Health Sciences and Biomedical Research KLEU, 2021
Multidrug resistance tuberculosis (MDR-TB) associated with the development of resistance to fluoroquinolones (FQs) especially ofloxacin is a matter of concern, as they had been earlier recommended drugs for usage in the MDR-TB treatment regimens, and ...
Ramesh S Kumar, K. R. Uma Devi, Azger Dusthackeer, Christy Rosaline Nirmal   +3 more
doaj   +1 more source

Molecular basis of ciprofloxacin (fluoroquinolone)-resistant in clinical isolates of Escherichia coli

Zanco Journal of Pure and Applied Sciences, 2020
It has recently been shown that antibiotic resistance is considered as one of the extremely imperative worrisome in medicine, with tremendously resistant pathogens of numerous species of bacteria demonstrating difficult to treat.
Ahmed Mohammed Tofiq
doaj   +1 more source

Molecular detection of fluoroquinolone-resistant Neisseria meningitidis by using mismatched PCR-restriction fragment length polymorphism technique

Frontiers in Cellular and Infection Microbiology, 2022
Ciprofloxacin (CIP) is a commonly used antibiotic for meningococcal chemoprophylaxis, and the mutations in the quinolone resistance-determining region of gyrA are associated with CIP-resistant Neisseria meningitidis. Here, we established a mismatched PCR-
Yusuke Ota, Reina Okada, Hideyuki Takahashi, Ryoichi Saito   +3 more
doaj   +1 more source