Results 171 to 180 of about 91,097 (243)

Single‐Nucleus Transcriptomics Uncovers Xaf1‐Driven PANoptosis as a Therapeutic Target in Aminoglycoside‐Induced Hearing Loss

Cell Proliferation, Volume 59, Issue 1, January 2026.
Neomycin induces increased expression of Xaf1 in cochlear HCs, triggering PANoptosis, which encompasses pyroptosis, apoptosis and necroptosis (left). Targeted Xaf1 knockdown in HCs through gene therapy can significantly inhibit the occurrence of PANoptosis in HCs (right).
Xinlin Wang, Hairong Xiao, Jiheng Wu, Yanqin Lin, Yiheng Ao, Zixuan Ye, Xin Tan, Fanliang Kong, Xin Chen, Renjie Chai, Shasha Zhang   +10 more
wiley   +1 more source

Study Models for Non-Syndromic Hearing Loss. [PDF]

Cells
Hoyau V, Leclère JC, Moisan S.
europepmc   +1 more source

Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms

Cell Proliferation, Volume 59, Issue 1, January 2026.
Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng, Zuping Wu, Mengjie Wu, Liang Xie, Qianming Chen   +4 more
wiley   +1 more source

Dicer Deletion in the Ear Can Cut Most Neurons and Their Innervation of Hair Cells to Project to the Ear and the Brainstem. [PDF]

Int J Mol Sci
Yamoah EN, Pavlinkova G, Lee JH, Kersigo J, Pierce ML, Fritzsch B.   +5 more
europepmc   +1 more source

The Sensory Ecology of Tsetse Flies: Neuroscience Perspectives on a Disease Vector

European Journal of Neuroscience, Volume 63, Issue 2, January 2026.
Tsetse flies (Glossina sp.) are important disease vectors that feed on vertebrate blood. Host‐seeking depends on a combination of sensory systems, from long‐range senses like olfaction and vision, to shorter‐range senses such as audition, mechanosensation, thermosensation and taste.
Andrea Adden, Lucia L. Prieto‐Godino
wiley   +1 more source

A sound vision: MYO7A gene therapy reaches the inner ear. [PDF]

J Physiol
Taiber S, Avraham KB.
europepmc   +1 more source

Developing Concepts for Neuroscience: A Philosophical Toolkit

European Journal of Neuroscience, Volume 63, Issue 2, January 2026.
Whether and how concepts should be developed depends on the phenomena that neuroscientists aim to describe, classify, and explain. These epistemic goals shape when introducing novel terms like “default mode network,” refining existing terms such as “hierarchy,” and retiring or replacing outdated ones such as “cortical columns” succeeds or fails to ...
Philipp Haueis, Daniel S. Margulies
wiley   +1 more source

Bioactive hydrogels for the reconstruction of sensorineural hearing loss. [PDF]

Bioact Mater
Pang X, Zhang X, Xu D, Bu C, Qiu Y, Feng P, Zhang B, Cheng H, Zhu Q, Tian L, Hu Y, Chai R.   +11 more
europepmc   +1 more source

Supporting Cell Division Is Not Required for Regeneration of Auditory Hair Cells After Ototoxic Injury In Vitro

Journal of the Association for Research in Otolaryngology, 2010
Jialin Shang, Jon Cafaro, Rachel Nehmer, J. Stone   +3 more
semanticscholar   +1 more source

Oxidative Stress—Related Serum Extracellular Vesicle miRNAs Indicate Symptom Severity and Cognitive Decline in Parkinson's Disease

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Oxidative stress and mitochondrial dysfunction are core mechanisms to dopaminergic neuronal death in Parkinson's disease (PD) and are regulated by microRNAs such as miR‐24‐3p, miR‐103a‐3p, miR‐320a‐3p, miR‐494‐3p, miR‐126‐5p, and miR‐543. Their expression was analyzed in serum extracellular vesicles of 93 PD patients by RT‐qPCR, as well as correlations
Violeta Belickienė, Aistė Pranckevičienė, Andrius Radžiūnas, Andrėja Strigauskaitė, Ovidijus Laucius, Paulina Vaitkienė   +5 more
wiley   +1 more source