Results 31 to 40 of about 53,617 (156)

Aminoglycoside-induced hair cell death of inner ear organs causes functional deficits in adult zebrafish (Danio rerio). [PDF]

PLoS ONE, 2013
Aminoglycoside antibiotics, like gentamicin, kill inner ear sensory hair cells in a variety of species including chickens, mice, and humans. The zebrafish (Danio rerio) has been used to study hair cell cytotoxicity in the lateral line organs of larval ...
Phillip M Uribe, Huifang Sun, Kevin Wang, James D Asuncion, Qi Wang, Chien-Wei Chen, Peter S Steyger, Michael E Smith, Jonathan I Matsui   +8 more
doaj   +1 more source

Regeneration of the auditory nerve - a cell transplantation study [PDF]

, 2011
Since in mammals, the hair cells or the spiral ganglion neurons (SGNs) in the inner ear do not regenerate, damage to these cells is an irreversible process.
Palmgren, Björn
core   +1 more source

Deletion of the Notch ligand Jagged1 during cochlear maturation leads to inner hair cell defects and hearing loss

Cell Death and Disease, 2022
The mammalian cochlea is an exceptionally well-organized epithelium composed of hair cells, supporting cells, and innervating neurons. Loss or defects in any of these cell types, particularly the specialized sensory hair cells, leads to deafness.
Felicia A. Gilels, Jun Wang, Anwen Bullen, Patricia M. White, Amy E. Kiernan   +4 more
doaj   +1 more source

Regeneration in the Auditory Organ in Cuban and African Dwarf Crocodiles (Crocodylus rhombifer and Osteolaemus tetraspis) Can We Learn From the Crocodile How to Restore Our Hearing?

Frontiers in Cell and Developmental Biology, 2022
Background: In several non-mammalian species, auditory receptors undergo cell renewal after damage. This has raised hope of finding new options to treat human sensorineural deafness.
Hao Li, Karin Staxäng, Monika Hodik, Karl-Gunnar Melkersson, Mathias Rask-Andersen, Helge Rask-Andersen   +5 more
doaj   +1 more source

Enlargement of ribbons in zebrafish hair cells increases calcium currents, but disrupts afferent spontaneous activity and timing of stimulus onset. [PDF]

, 2017
In sensory hair cells of auditory and vestibular organs, the ribbon synapse is required for the precise encoding of a wide range of complex stimuli. Hair cells have a unique presynaptic structure-the synaptic ribbon-that organizes both synaptic vesicles ...
Beirl, A., He, X.J., Kindt, K.S., Marcotti, W., Nicolson, T., Olt, J., Petralia, R.S., Schreck, M., Sheets, L., Trapani, J.G., Wang, Y-X., Zhang, Q.   +11 more
core   +1 more source

Static length changes of cochlear outer hair cells can tune low-frequency hearing.

PLoS Computational Biology, 2018
The cochlea not only transduces sound-induced vibration into neural spikes, it also amplifies weak sound to boost its detection. Actuators of this active process are sensory outer hair cells in the organ of Corti, whereas the inner hair cells transduce ...
Nikola Ciganović, Rebecca L Warren, Batu Keçeli, Stefan Jacob, Anders Fridberger, Tobias Reichenbach   +5 more
doaj   +1 more source

Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells. [PDF]

PLoS ONE, 2014
To determine whether activated Notch can promote a supporting cell fate during sensory cell differentiation in the inner ear.An activated form of the Notch1 receptor (NICD) was expressed in early differentiating hair cells using a Gfi1-Cre mouse allele ...
Grace Savoy-Burke, Felicia A Gilels, Wei Pan, Diana Pratt, Jianwen Que, Lin Gan, Patricia M White, Amy E Kiernan   +7 more
doaj   +1 more source

Inner-ear abnormalities and their functional consequences in Belgian Waterslager canaries (Serinus canarius) [PDF]

, 1994
Recent reports of elevated auditory thresholds in canaries of the Belgian Waterslager strain have shown that this strain has an inherited auditory deficit in which absolute auditory thresholds at high frequencies (i.e. above 2.0 kHz) are as much as 40 dB
Brown, Cleveland, Corwin, Cotanche, Cotanche, Cotanche, Cousillas, Dooling, Dooling, Fischer, Geoffrey A. Manley, Girod, Girod, Gleich, Gleich, Gleich, Gleich, Gleich, Gummer, Guttinger, Hashino, Hashino, Köppl, Manley, Manley, Manley, Marler, Nottebohm, Okanoya, Okanoya, Okanoya, Okanoya, Okanoya, Otto Gleich, Patuzzi, Pickles, Robert J. Dooling, Saunders, Steel, Steel, Stresemann, Tilney, Waser   +42 more
core   +1 more source

Hair cell regeneration, reinnervation, and restoration of hearing thresholds in the avian hearing organ

Cell Reports
Summary: Hearing starts, at the cellular level, with mechanoelectrical transduction by sensory hair cells. Sound information is then transmitted via afferent synaptic connections with auditory neurons.
Mitsuo P. Sato, Nesrine Benkafadar, Stefan Heller   +2 more
doaj   +1 more source

C1ql1 is expressed in adult outer hair cells of the cochlea in a tonotopic gradient.

PLoS ONE, 2021
Hearing depends on the transduction of sounds into neural signals by the inner hair cells of the cochlea. Cochleae also have outer hair cells with unique electromotile properties that increase auditory sensitivity, but they are particularly susceptible ...
Joyshree Biswas, Robert S Pijewski, Rohit Makol, Tania G Miramontes, Brianna L Thompson, Lyndsay C Kresic, Alice L Burghard, Douglas L Oliver, David C Martinelli   +8 more
doaj   +1 more source