Results 31 to 40 of about 22,677 (167)
Frontiers in Ecology and Evolution, 2022 IntroductionThe inner ear hair cells of fishes can provide insight into the early evolution of vertebrate inner ear structure. Fishes represent some of the first vertebrates to evolve auditory capacity, and the same basic structure, the sensory hair cell,
Derek J. Sauer +2 more
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Aminoglycoside-induced hair cell death of inner ear organs causes functional deficits in adult zebrafish (Danio rerio). [PDF]
PLoS ONE, 2013 Aminoglycoside antibiotics, like gentamicin, kill inner ear sensory hair cells in a variety of species including chickens, mice, and humans. The zebrafish (Danio rerio) has been used to study hair cell cytotoxicity in the lateral line organs of larval ...
Phillip M Uribe +8 more
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The Small GTPase Rac1 Regulates Auditory Hair Cell Morphogenesis [PDF]
The Journal of Neuroscience, 2009 Morphogenesis of sensory hair cells, in particular their mechanotransduction organelle, the stereociliary bundle, requires highly organized remodeling of the actin cytoskeleton. The roles of Rho family small GTPases during this process remain unknown.
Cynthia M, Grimsley-Myers +3 more
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Cell Death and Disease, 2022 The mammalian cochlea is an exceptionally well-organized epithelium composed of hair cells, supporting cells, and innervating neurons. Loss or defects in any of these cell types, particularly the specialized sensory hair cells, leads to deafness.
Felicia A. Gilels +4 more
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Notch Signaling and the Emergence of Auditory Hair Cells [PDF]
Archives of Otolaryngology–Head & Neck Surgery, 2000 Recent insights into the mechanisms that determine a hair cell's fate have emerged from studies on invertebrate sensory organs and the avian inner ear. These mechanisms have important implications for our understanding of the possible therapeutic management of sensorineural deafness.
J, Weir, M N, Rivolta, M C, Holley
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Static length changes of cochlear outer hair cells can tune low-frequency hearing.
PLoS Computational Biology, 2018 The cochlea not only transduces sound-induced vibration into neural spikes, it also amplifies weak sound to boost its detection. Actuators of this active process are sensory outer hair cells in the organ of Corti, whereas the inner hair cells transduce ...
Nikola Ciganović +5 more
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Frontiers in Cell and Developmental Biology, 2022 Background: In several non-mammalian species, auditory receptors undergo cell renewal after damage. This has raised hope of finding new options to treat human sensorineural deafness.
Hao Li +5 more
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Cell ReportsSummary: Hearing starts, at the cellular level, with mechanoelectrical transduction by sensory hair cells. Sound information is then transmitted via afferent synaptic connections with auditory neurons.
Mitsuo P. Sato +2 more
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Cellular studies of auditory hair cell regeneration in birds [PDF]
Proceedings of the National Academy of Sciences, 2000 A decade ago it was discovered that mature birds are able to regenerate hair cells, the receptors for auditory perception. This surprising finding generated hope in the field of auditory neuroscience that new hair cells someday may be coaxed to form in another class of warm-blooded vertebrates, mammals.
J S, Stone, E W, Rubel
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Hair cell regeneration in the avian auditory epithelium
The International Journal of Developmental Biology, 2007 Regeneration of sensory hair cells in the mature avian inner ear was first described just over 20 years ago. Since then, it has been shown that many other non-mammalian species either continually produce new hair cells or regenerate them in response to trauma.
Jennifer S, Stone, Douglas A, Cotanche
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