Results 31 to 40 of about 122,731 (252)

Pejvakin-mediated pexophagy protects auditory hair cells against noise-induced damage

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Noise-induced hearing loss is a highly prevalent form of sensorineural hearing impairment affecting individuals of all ages. Noise exposure triggers a rapid increase in reactive oxygen species (ROS) levels, causing oxidative damage to ...
Jean Defourny, Alain Aghaie, Isabelle Perfettini, P. Avan, S. Delmaghani, C. Petit   +5 more
semanticscholar   +1 more source

Role of somatostatin receptor-2 in gentamicin-induced auditory hair cell loss in the Mammalian inner ear. [PDF]

PLoS ONE, 2014
Hair cells and spiral ganglion neurons of the mammalian auditory system do not regenerate, and their loss leads to irreversible hearing loss. Aminoglycosides induce auditory hair cell death in vitro, and evidence suggests that phosphatidylinositol-3 ...
Yves Brand, Vesna Radojevic, Michael Sung, Eric Wei, Cristian Setz, Andrea Glutz, Katharina Leitmeyer, Daniel Bodmer   +7 more
doaj   +1 more source

CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells

Nature Communications, 2017
Inner ear hair cells detect sound through deflection of stereocilia, the microvilli-like projections that are arranged in rows of graded heights. Calcium and integrin-binding protein 2 is essential for hearing and localizes to stereocilia, but its exact ...
A. Giese, Yiquan Tang, G. P. Sinha, M. Bowl, Adam C Goldring, A. Parker, Mary J. Freeman, Steve D. M. Brown, S. Riazuddin, R. Fettiplace, W. Schafer, G. Frolenkov, Zubair M. Ahmed   +12 more
semanticscholar   +1 more source

Autophagy protects auditory hair cells against neomycin-induced damage

Autophagy, 2017
Aminoglycosides are toxic to sensory hair cells (HCs). Macroautophagy/autophagy is an essential and highly conserved self-digestion pathway that plays important roles in the maintenance of cellular function and viability under stress.
Zuhong He, Lingna Guo, Y. Shu, Qiaojun Fang, Han Zhou, Yongze Liu, Dingding Liu, Ling Lu, Xiaoli Zhang, Xiaoqiong Ding, Dong Liu, Mingliang Tang, Weijia Kong, S. Sha, Huawei Li, Xia Gao, R. Chai   +16 more
semanticscholar   +1 more source

Resolution of subcomponents of synaptic release from post-synaptic currents in rat hair-cell/auditory-nerve fiber synapses.

Journal of Neurophysiology, 2021
The synapse between inner hair cells and auditory nerve fiber dendrites shows large excitatory postsynaptic currents (EPSCs), which are either monophasic or multiphasic.
E. Young, Jingjing Sherry Wu (武靜靜), Mamiko Niwa, E. Glowatzki   +3 more
semanticscholar   +1 more source

Active hair bundle movements in auditory hair cells [PDF]

The Journal of Physiology, 2006
The frequency selectivity of mammalian hearing depends on not only the passive mechanics of the basilar membrane but also an active amplification of the mechanical stimulus by the cochlear hair cells. The common view is that amplification stems from the somatic motility of the outer hair cells (OHCs), changes in their length impelled by voltage ...
openaire   +2 more sources

Restoration of auditory evoked responses by human ES-cell-derived otic progenitors [PDF]

, 2012
Deafness is a condition with a high prevalence worldwide, produced primarily by the loss of the sensory hair cells and their associated spiral ganglion neurons (SGNs). Of all the forms of deafness, auditory neuropathy is of particular concern.
Abbas, L., Andrews, P.W., Chen, W., Eshtan, S.J., Johnson, S.L., Jongkamonwiwat, N., Kuhn, S., Marcotti, W., Milo, M., Moore, H.D., Rivolta, M.N., Thurlow, J.K.   +11 more
core   +1 more source

Localization of TMC1 and LHFPL5 in auditory hair cells in neonatal and adult mice

The FASEB Journal, 2019
The channel that governs mechanotransduction (MT) by hair cells in the inner ear has been investigated intensively for 4 decades, but its precise molecular composition remains enigmatic. Transmembrane channel‐like protein 1 (TMC1) was recently identified
Xiaofen Li, Xiaojie Yu, Xibing Chen, Zhengzhao Liu, Guangqin Wang, Chao Li, E. Wong, M. Sham, Jie Tang, Jufang He, Wei Xiong, Zhiyong Liu, Pingbo Huang   +12 more
semanticscholar   +1 more source

Retardation of cochlear maturation and impaired hair cell function caused by deletion of all known thyroid hormone receptors [PDF]

, 2001
The deafness caused by early onset hypothyroidism indicates that thyroid hormone is essential for the development of hearing. We investigated the underlying roles of the TRa1 and TRß thyroid hormone receptors in the auditory system using receptor ...
Forrest, Douglas, Goodyear, Richard, Kelley, Matthew W, Lisoukov, Igor, Ng, Lily, Oliver, Dominik, Richardson, Guy, Rüsch, Alfons, Vennström, Björn   +8 more
core   +1 more source

Mechanotransduction current is essential for stability of the transducing stereocilia in mammalian auditory hair cells

eLife, 2017
Mechanotransducer channels at the tips of sensory stereocilia of inner ear hair cells are gated by the tension of 'tip links' interconnecting stereocilia. To ensure maximal sensitivity, tip links are tensioned at rest, resulting in a continuous influx of
A. C. Vélez-Ortega, Mary J. Freeman, Artur A. Indzhykulian, J. Grossheim, G. Frolenkov   +4 more
semanticscholar   +1 more source