Results 91 to 100 of about 5,630,806 (253)

"Studies on the cardiomyocytic potential of dermal stem cells” [PDF]

, 2008
In Europe, diseases of the heart and circulatory system are the main cause of death; 48% of all deaths are from coronary heart disease, accounting for over 4.30 million deaths each year (European cardiovascular disease statistics 2008). Identifying stem
Cormack, Suzanne Marie
core  

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Stem cell decisions:A twist of fate or a niche market? [PDF]

, 2014
Establishing and maintaining cell fate in the right place at the right time is a key requirement for normal tissue maintenance. Stem cells are at the core of this process.
Näthke, Inke, Nathke, Inke; id_orcid, Januschke, Jens, Januschke, Jens; id_orcid   +3 more
core   +1 more source

Mechanotransductive Differentiation of Hair Follicle Stem Cells Derived from Aged Eyelid Skin into Corneal Endothelial-Like Cells

, 2022
Corneal endothelial insufficiency is one of the leading causes of blindness. The main contemporary treatment for corneal blindness is endothelial keratoplasty, which, however, is unsatisfactory as a medical therapy due to the lack of donor corneas and ...
Olszewski, Christian, Maassen, Jessika, Guenther, Rebecca, Gutermuth, Angela, Skazik-Voogt, Claudia   +4 more
core   +1 more source

Optimized micro‐sized cell sphere‐matrix niche co‐aggregates promote efficient oral and craniomaxillofacial bone regeneration

BMEMat, EarlyView.
The construct of cell‐niche co‐aggregates (GelMA‐SHED sphere‐DDMPs) promotes cranial and periodontal bone regeneration and ensures angiogenic‐osteogenic coupling by downregulating miR‐34c‐5p to enhance the expression of NOTCH1 and its intracellular domain (NICD).
Xiao‐Hui Zhang, Shi‐Han Mu, Yi‐Han Xiao, Lu‐Fan Yang, Peng‐Fei Wang, Teng‐Fei Hu, Jun‐Xi He, Jiong‐Zhen Piao, Sha Zhang, Jin‐Yu Liu, Yi‐De He, Ying‐Ying Wu, Si‐Qi Ying, Xin‐Yue Cai, Chen‐Han Li, Zi‐Qi Zhang, Xiao Lei, Ji Chen, Jian‐Fei Liang, Yan Jin, Bing‐Dong Sui, Chao Ma, Chen‐Xi Zheng, Fang Jin   +23 more
wiley   +1 more source

BMP Signaling and Its pSMAD1/5 Target Genes Differentially Regulate Hair Follicle Stem Cell Lineages [PDF]

, 2014
SummaryHair follicle stem cells (HFSCs) and their transit amplifying cell (TAC) progeny sense BMPs at defined stages of the hair cycle to control their proliferation and differentiation. Here, we exploit the distinct spatial and temporal localizations of
Genander, Maria, Cook, Peter J., Genander, M,, Mertz, Aaron F., Mertz, AF, Sandberg, R,, Cook, PJ, Keyes, BE, Keyes, Brice E., Ramsköld, Daniel, Sandberg, Rickard, Fuchs, Elaine, Ramskold, D, Fuchs, E   +13 more
core   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Stem cell-based approaches for alopecia: A narrative review of current and emerging treatment strategies

Cell Transplantation
The natural cycle of hair growth and shedding is continuous. However, an abnormal rate of hair regrowth can signal alopecia, a condition characterized by excessive hair loss and thinning.
Pitsunan Paphawannasri, Tulyapruek Tawonsawatruk, Jitrada Phetfong, Aungkura Supokawej   +3 more
doaj   +1 more source

Neurotrophic Effects of Silibinin on Differentiation of Hair Follicle Stem Cells to Neurons [PDF]

Neurotrophic Effects of Silibinin on Differentiation of Hair Follicle Stem Cells to NeuronsAbstract Background and Objectives: Hair Follicle Bulge region due to its availability and abundance is one of the areas which is easily accessible to Multi-potent
آسالگو, سارا, کردستانی شرق, بهاره, نوبخت, ملیحه, رهبر روشندل, ناهید, نجف زاده, نوروز, موسوی زاده, کاظم   +5 more
core  

Lgr5 marks cycling, yet long-lived, hair follicle stem cells.

, 2008
In mouse hair follicles, a group of quiescent cells in the bulge is believed to have stem cell activity. Lgr5, a marker of intestinal stem cells, is expressed in actively cycling cells in the bulge and secondary germ of telogen hair follicles and in the ...
Clevers, H., Kasper, M., van Es, J.H., Snippert, H.J.G., Jaks, V., Toftgard, R., Barker, N.   +6 more
core   +1 more source