Results 91 to 100 of about 21,262 (243)

Structural insights into the HDAC4–MEF2A–DNA complex and its implication in long-range transcriptional regulation

Nucleic Acids Research
Class IIa Histone deacetylases (HDACs), including HDAC4, 5, 7 and 9, play key roles in multiple important developmental and differentiation processes.
S. Dai, Liang Guo, Raja Dey, M. Guo, Xiangqian Zhang, D. Bates, Justin Cayford, Longying Jiang, Hudie Wei, Zhuchu Chen, Ye Zhang, Lin Chen, Yongheng Chen   +12 more
semanticscholar   +1 more source

circ-LRP6 contributes to osteosarcoma progression by regulating the miR-141-3p/HDAC4/HMGB1 axis

International Journal of Oncology, 2022
Circular RNA-lipoprotein receptor 6 (circ-LRP6) serves a role in promoting the tumorigenesis of retinoblastoma, esophageal squamous cell cancer and oral squamous cell carcinoma; however, whether circ-LRP6 demonstrates the same effect in osteosarcoma (OS)
Yali Yu, Guixiang Dong, Zijun Li, Yan Zheng, Zhisong Shi, Guanghui Wang   +5 more
semanticscholar   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

HDAC4 Regulates Neuronal Survival in Normal and Diseased Retinas [PDF]

Science, 2009
Histone deacetylase 4 (HDAC4) shuttles between the nucleus and cytoplasm and serves as a nuclear co-repressor that regulates bone and muscle development. We report that HDAC4 regulates the survival of retinal neurons in the mouse in normal and pathological conditions.
Bo, Chen, Constance L, Cepko
openaire   +2 more sources

CircAKT3 alleviates postoperative cognitive dysfunction by stabilizing the feedback cycle of miR-106a-5p/HDAC4/MEF2C axis in hippocampi of aged mice

Cellular and Molecular Life Sciences
Circular RNAs (circRNAs) have garnered significant attention in the field of neurodegenerative diseases including Alzheimer’s diseases due to their covalently closed loop structure.
Xuan Wang, Xiaole Tang, Pengfei Zhu, Dongyu Hua, Zheng Xie, Mingke Guo, Mengxin Que, Jing Yan, Xing Li, Q. Xia, Xiaoxiao Luo, Jiangjiang Bi, Yilin Zhao, Zhiqiang Zhou, Shiyong Li, Ailin Luo   +15 more
semanticscholar   +1 more source

Transcriptomic and Epigenetic Regulation of Disuse Atrophy and the Return to Activity in Skeletal Muscle [PDF]

, 2017
Physical inactivity and disuse are major contributors to age-related muscle loss. Denervation of skeletal muscle has been previously used as a model with which to investigate muscle atrophy following disuse. Although gene regulatory networks that control
Acharyya S., Adam P. Sharples, Alex Gutteridge, Andrew G. Fisher, Barrès R., Batt J., Beker F., Bodine S. C., Bodine S. C., Bogdanovi´c O., Bonaldo P., Buffelli M., Claire Stewart, Cohen S., Cohen T. J., Colquhoun D., Davis P., De Boer M. D., Deitrick J. E., DupontSalter A.C., Eddins M. J., Ehrlich K.C., Ferrando A. A., Giangregorio L., Gibson J. N., Giniatullin R., Goldberg A. L., Hasselgren P. O., Ibebunjo C., Ibebunjo C., Irizarry R. A., Irizarry R. A., Jacobsen S. C., Jaenisch R., Janssen I., Jarvis J. C., Jarvis J. C., Jonathan C. Jarvis, Judy M. Coulson, Kalyani R.R., Le Grand F., LeBlanc A.D., Lecker S. H., Llano‐Diez M., Macpherson P. C. D., Magnusson C., Michel R. N., Moresi V., Nikawa T., Reik W., Robert A. Seaborne, Sandri M., Schmittgen T. D., Sharples A. P., Sharples A. P., Strassburg S., Tan B. H., Tang H., Tang H., Tang W. W., Thomas M. Hughes, Trasler J., Yu X. M.   +62 more
core   +3 more sources

Selective targeting of cortactin tandem repeat acetylation by human lysine deacetylases

The FEBS Journal, EarlyView.
Cortactin function is regulated by acetylation at several lysine residues within its tandem repeat region. Using genetic code expansion to generate cortactin variants containing precisely defined acetylation marks, we show that HDAC6 is the primary enzyme removing these modifications, with SIRT1 and SIRT2 also acting at selected sites but with lower ...
Jan Komarek, Miroslava Vosahlikova, Zsofia Kutil, Zora Novakova, Julia Kudlacova, Ruzena Tuckova, Marat Meleshin, Barbora Havlinova, Pavlina Jaklova, Jana Ptackova, Cordelia Schiene‐Fischer, Mike Schutkowski, Cyril Barinka   +12 more
wiley   +1 more source

Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4 [PDF]

Proceedings of the National Academy of Sciences, 2012
Stress induces long-lasting changes in neuronal gene expression and cholinergic neurotransmission, but the underlying mechanism(s) are incompletely understood. Here, we report that chromatin structure and histone modifications are causally involved in this transcriptional memory. Specifically, the AChE gene encoding the acetylcholine-hydrolyzing enzyme
Badi Sri, Sailaja, Dorit, Cohen-Carmon, Gabriel, Zimmerman, Hermona, Soreq, Eran, Meshorer   +4 more
openaire   +2 more sources

Hdac4 Modulates Bone Biology Via Regulation Of Mineralization And Ferroptosis

International Dental Journal
Aim or purpose: To investigate the role of HDAC4 in bone homeostasis and regeneration, focusing on its epigenetic regulation of mesenchymal stem cells (MSCs) mineralization and osteoblasts ferroptosis.
Xiaofeng Wang, Xudong Wang, Shuai Wang
doaj   +1 more source

SMRT-mediated co-shuttling enables export of class IIa HDACs independent of their CaM kinase phosphorylation sites [PDF]

, 2012
The Class IIa histone deacetylases (HDAC)4 and HDAC5 play a role in neuronal survival and behavioral adaptation in the CNS. Phosphorylation at 2/3 N-terminal sites promote their nuclear export.
Chawla, Sangeeta, Hardingham, Giles E, Skehel, Paul, Soriano, Francesc X   +3 more
core   +2 more sources