Results 101 to 110 of about 21,262 (243)

Melatonin and the Dental Pulp: A Scoping Review

International Endodontic Journal, EarlyView.
ABSTRACT Background In general medicine, melatonin is known to enhance wound healing and promote stem cell differentiation. Its potential relevance in endodontics, however, remains underexplored. Objectives This scoping review aimed to systematically assess the available evidence on the effects of melatonin (a) on dental pulp tissue and (b) on human ...
Jasmin Schäfer, Konrad Kleszczynski, Edgar Schäfer   +2 more
wiley   +1 more source

A role for the histone deacetylase HDAC4 in the life-cycle of HIV-1-based vectors

Virology Journal, 2010
HIV-1 integration is mediated by the HIV-1 integrase protein, which joins 3'-ends of viral DNA to host cell DNA. To complete the integration process, HIV-1 DNA has to be joined to host cell DNA also at the 5'-ends. This process is called post-integration
Kao Gary D, Yeung Jennifer, Smith Johanna A, Daniel René   +3 more
doaj   +1 more source

Knockdown of circ_0003928 ameliorates high glucose-induced dysfunction of human tubular epithelial cells through the miR-506-3p/HDAC4 pathway in diabetic nephropathy

European Journal of Medical Research, 2022
Background Previous data have indicated the importance of circular RNA (circRNA) in the pathogenesis of diabetic nephropathy (DN). The study is designed to investigate the effects of circ_0003928 on oxidative stress and apoptosis of high glucose (HG ...
Qiong Liu, Yuanyuan Cui, Nana Ding, Chang-Lin Zhou   +3 more
semanticscholar   +1 more source

Characteristics of Intronic and Intergenic Human miRNAs and Features of their Interaction with mRNA [PDF]

, 2011
International audienceRegulatory relationships of 686 intronic miRNA and 784 intergenic miRNAs with mRNAs of 51 intronic miRNA coding genes were established.
Atambayeva, Shara, Berillo, Olga, Issabekova, Assel, Ivashchenko, Anatoliy,, Khailenko, Vladimir, Regnier, Mireille   +5 more
core   +2 more sources

The Dual Immunoregulatory Role of CREB3L1 Underlying Latent and Severe Tuberculosis Clinical Manifestation

Immunology, EarlyView.
RNA‐seq of lungs and livers from Mycobacterium tuberculosis‐infected mice with distinct disease outcomes revealed organ‐specific responses driven by differences in immune activity and bacterial burden. Meta‐analysis identified orthologous genes shared with human latent TB and mouse liver, with Creb3l1, Myo7b, Cyyr1 and Cbs differentially expressed and ...
Felipe T. Lima, Ricardo C. Castro, Francisco R. Javier, Caroline Fontanari, Valdes R. Bollela, Rogerio S. Rosada, Célio L. Silva, Lúcia H. Faccioli, Luiz G. Gardinassi, Fabiani G. Frantz   +9 more
wiley   +1 more source

Histone deacetylase 4 protects from denervation and skeletal muscle atrophy in a murine model of amyotrophic lateral sclerosisResearch in context

EBioMedicine, 2019
Background: Histone deacetylase 4 (HDAC4) has been proposed as a target for Amyotrophic Lateral Sclerosis (ALS) because it mediates nerve-skeletal muscle interaction and since its expression in skeletal muscle correlates with the severity of the disease.
Eva Pigna, Elena Simonazzi, Krizia Sanna, Krzysztof Marian Bernadzki, Tomek Proszynski, Constantin Heil, Daniela Palacios, Sergio Adamo, Viviana Moresi   +8 more
doaj   +1 more source

SP1 Promotes HDAC4 Expression and Inhibits HMGB1 Expression to Reduce Intestinal Barrier Dysfunction, Oxidative Stress, and Inflammatory Response after Sepsis

Journal of Innate Immunity, 2022
As a serious and elusive syndrome caused by infection, sepsis causes a high rate of mortality around the world. Our investigation aims at exploring the role and possible mechanism of specificity protein-1 (SP1) in the development of sepsis. A mouse model
Zhen Liu, Xi Wang, Chenxiao Li, Xue-Yan Liu, Xiao Guo, Yang Li, Youpeng Chen, H. Ye, Huai-Sheng Chen   +8 more
semanticscholar   +1 more source

The role of histone deacetylase 4 (HDAC4) in acquired cisplatin-resistant ovarian cancer

, 2011
Resistance to platinum is a major problem in the treatment of ovarian cancer. Molecular profiling of isogenic ovarian cancer cell line pairs derived from tumour cells pre- and post- clinical resistance, identified that histone deacetylase 4 (HDAC4) is
Alfraidi, Albanderi Mohammed, Alfraidi, Albanderi Mohammed   +1 more
core   +1 more source

The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass [PDF]

, 2013
Although the canonical transforming growth factor β signaling pathway represses skeletal muscle growth and promotes muscle wasting, a role in muscle for the parallel bone morphogenetic protein (BMP) signaling pathway has not been defined. We report,
Amthor, Amthor, Ball, Bayat, Bianca C. Bernardo, Bodine, Bogdanovich, Bradley J. Turner, Catherine E. Winbanks, Chung, Claudia Beyer, Clever, Cohen, Craig A. Harrison, Donaldson, Dworkin, Dworkin, Fischle, Gregorevic, Grönroos, Gurney, Hayashi, Heitman, Holley, Hongwei Qian, Ibebunjo, Imamura, Ishida, Julie R. McMullen, Justin L. Chen, Kalista, Kambadur, Katagiri, Kevin I. Watt, Langenfeld, Lars Larsson, Latres, Lee, Lee, Lee, Massagué, Mathews, McCabe, McPherron, Moresi, Musarò, Nakao, Nickel, Ochala, Paul Gregorevic, Pescatori, Potthoff, Pourquié, Rachel E. Thomson, Rafael, Rebbapragada, Rommel, Ruschke, Sako, Sandri, Sartori, Sartori, Sean L. McGee, Shioi, Stitt, Suryawan, Tang, Timothy Connor, Townsend, Trendelenburg, Winbanks, Winbanks, Yamamoto, Yingying Liu, Zhou, Zimmerman   +75 more
core   +2 more sources

A Multifunctional β‐Defensin‐3 Mimetic Peptide Modulates Host–Biofilm Interactions and Reduces Bone Loss in Periodontitis

Journal of Periodontal Research, EarlyView.
BDMP, a peptide that can penetrate cells and tissues, offering antimicrobial and anti‐inflammatory effects, has been identified as a potential new therapy for periodontitis. ABSTRACT Aim This study evaluated the potential of a beta‐defensin‐3 mimetic peptide (BDMP), a synthetic cell‐penetrating peptide with antimicrobial and immunomodulatory properties,
Beom Soo Jo, Dong Woo Lee, Ji‐Young Lee, Sanghui Seok, Yu‐Bin Kim, Jue‐Yeon Lee, Shin‐Young Park, Young Dan Cho, Yang Jo Seol, Yoon Shin Park, Shahram Ghanaati, Homayoun H. Zadeh, Chong Pyung Chung, Yoon Jeong Park   +13 more
wiley   +1 more source