Results 41 to 50 of about 21,262 (243)

The Effect of miR-140-5p with HDAC4 towards Growth and Differentiation Signaling of Chondrocytes in Thiram-Induced Tibial Dyschondroplasia

International Journal of Molecular Sciences, 2023
There is evidence to suggest that microRNA-140-5p (miR-140), which acts as a suppressor, is often elevated and has a role in various malignancies. Nevertheless, neither the function nor the mechanisms in chondrocytes linked with bone disorders, e.g ...
Wangyuan Yao, M. F. Kulyar, Yanmei Ding, Haitao Du, Jiajia Hong, Kyein San Loon, Shah Nawaz, Jiakui Li   +7 more
semanticscholar   +1 more source

Coordinated actions of microRNAs with other epigenetic factors regulate skeletal muscle development and adaptation [PDF]

, 2017
Epigenetics plays a pivotal role in regulating gene expression in development, in response to cellular stress or in disease states, in virtually all cell types.
Adamo, Sergio, Bianchi, Marzia, Moresi, Viviana, Renzini, Alessandra   +3 more
core   +1 more source

Estrogen-dependent dynamic profile of eNOS-DNA associations in prostate cancer [PDF]

, 2013
In previous work we have documented the nuclear translocation of endothelial NOS (eNOS) and its participation in combinatorial complexes with Estrogen Receptor Beta (ERβ) and Hypoxia Inducible Factors (HIFs) that determine localized chromatin remodeling ...
A Grasselli, A Re, A Watahiki, Agnese Re, Alessandro Guffanti, Alfredo Pontecorvi, Antonella Farsetti, Armando Felsani, Arturo Londono-Vallejo, Aurora Aiello, BD Gehm, C Liu, C Zang, Carlo Gaetano, Claudia Colussi, Costanza Emanueli, CS Ross-Innes, D Bonci, D Fukumura, D Lodygin, DM Huffman, E Schreiber, G Garcia-Cardena, I Mattagajasingh, J Lu, J Veldscholte, JA Baur, JS Carroll, JS Horoszewicz, KH Lim, KP Porkka, L Ying, L Zeng, LJ Zhu, Luis Jaime Castro-Vega, M Yamakuchi, M Yamakuchi, Maurizio C. Capogrossi, MC Haigis, MD Kornberg, MD Robinson, ME Ritchie, MS Zaman, MV Iorio, N Hah, N Nadiminty, NR Bertos, OM Grober, P Gandellini, P Giovannelli, Q Wu, RT Prehn, S Anders, S Baranwal, S Kyo, S Misiti, S Nanni, S Nanni, S Nanni, S Volinia, Silvia Bacchetti, Simona Nanni, T Liu, T Vanhaecke, Valentina Benvenuti, W Fischle, Y Zhang   +66 more
core   +5 more sources

HDAC4 Regulates the Proliferation, Differentiation and Apoptosis of Chicken Skeletal Muscle Satellite Cells

Animals, 2020
The development of skeletal muscle satellite cells (SMSCs) is a complex process that could be regulated by many genes. Previous studies have shown that Histone Deacetylase 4 (HDAC4) plays a critical role in cell proliferation, differentiation, and ...
Jing Zhao, Xiaoxu Shen, Xinao Cao, Haorong He, Shunshun Han, Yuqi Chen, Can Cui, Yuanhang Wei, Yan Wang, Diyan Li, Qing Zhu, Huadong Yin   +11 more
doaj   +1 more source

The histone deacetylase HDAC4 regulates long-term memory in Drosophila. [PDF]

PLoS ONE, 2013
A growing body of research indicates that pharmacological inhibition of histone deacetylases (HDACs) correlates with enhancement of long-term memory and current research is concentrated on determining the roles that individual HDACs play in cognitive ...
Helen L Fitzsimons, Silvia Schwartz, Fiona M Given, Maxwell J Scott   +3 more
doaj   +1 more source

N6-methyladenosine (m6A) methyltransferase METTL3 regulates sepsis-induced myocardial injury through IGF2BP1/HDAC4 dependent manner

Cell Death Discovery, 2022
Recent studies have identified that N6-methyladenosine (m6A) extensively participates in the myocardial injury pathophysiological process. However, the role of m6A on sepsis-induced myocardial injury is still unclear.
Hao Shen, Keliang Xie, Miaomiao Li, Qianyu Yang, Xiaoye Wang   +4 more
semanticscholar   +1 more source

Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy. [PDF]

, 2013
Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a central role in pathological cardiac hypertrophy, but the mechanisms by which it modulates gene activity in the nucleus to mediate hypertrophic signaling remain unclear. Here, we report that
An, Woojin, Awad, Salma, Bai, Yan, Bers, Donald, Kedes, Larry, Kunhi, Muhammad, Little, Gillian H, Poizat, Coralie   +7 more
core   +1 more source

HDAC4 promotes the growth and metastasis of gastric cancer via autophagic degradation of MEKK3

British Journal of Cancer, 2022
Histone deacetylases (HDACs) have been shown to be involved in tumorigenesis, but their precise role and molecular mechanisms in gastric cancer (GC) have not yet been fully elucidated. Bioinformatics screening analysis, qRT-PCR, and immunohistochemistry (
Weicheng Zang, Yilin Hu, Chengjia Qian, Ying Feng, Jia-Zhou Liu, Jun-ling Yang, Hua Huang, Yi-zhun Zhu, Wanjiang Xue   +8 more
semanticscholar   +1 more source

HIV Exploits Antiviral Host Innate GCN2-ATF4 Signaling for Establishing Viral Replication Early in Infection. [PDF]

, 2017
Antiviral innate host defenses against acute viral infections include suppression of host protein synthesis to restrict viral protein production.
Clarissa Santos Rocha, Erica A. Mendes, George R. Thompson, Guochun Jiang, Joseph K. Wong, Lauren A. Hirao, Ruth Ruprecht, Satya Dandekar, Vinayaka R. Prasad, Yuyang Tang   +9 more
core   +2 more sources

Hdac4 Regulates the Proliferation of Neural Crest-Derived Osteoblasts During Murine Craniofacial Development

Frontiers in Physiology, 2022
Craniofacial development involves the regulation of a compendium of transcription factors, signaling molecules, and epigenetic regulators. Histone deacetylases (HDACs) are involved in the regulation of cell proliferation, differentiation, and homeostasis
Nayoung Ha, Nayoung Ha, Jian Sun, Jian Sun, Qian Bian, Qian Bian, Dandan Wu, Dandan Wu, Xudong Wang, Xudong Wang   +9 more
doaj   +1 more source