Results 71 to 80 of about 21,262 (243)

HDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers

Genome Biology, 2021
Cellular senescence is a permanent state of replicative arrest defined by a specific pattern of gene expression. The epigenome in senescent cells is sculptured in order to sustain the new transcriptional requirements, particularly at enhancers and super ...
Eros Di Giorgio, Harikrishnareddy Paluvai, Emiliano Dalla, Liliana Ranzino, A. Renzini, V. Moresi, Martina Minisini, Raffaella Picco, C. Brancolini   +8 more
semanticscholar   +1 more source

MicroRNA Profiling and Bioinformatics Target Analysis in Dorsal Hippocampus of Chronically Stressed Rats: Relevance to Depression Pathophysiology [PDF]

, 2018
Indexación: Scopus.1Laboratory of Neuroplasticity and Neurogenetics, Faculty of Chemical and Pharmaceutical Sciences, Department of Biochemistry and Molecular Biology, Universidad de Chile, Santiago, Chile, 2National Institute of Environmental Health ...
Aguayo, F.I., Aliaga, E., Cidlowski, J.A., García-Pérez, M.A., García-Rojo, G., Gutiérrez, R.A., Moyano, T.C., Muñoz-Llanos, M., Pacheco, A., Rojas, P.S., Tejos-Bravo, M., Vidal, E.A., Xu, X.   +12 more
core   +1 more source

Role of a novel circRNA-CGNL1 in regulating pancreatic cancer progression via NUDT4–HDAC4–RUNX2–GAMT-mediated apoptosis

Molecular Cancer
Pancreatic cancer (PC) is an extremely malignant tumor with low survival rate. Effective biomarkers and therapeutic targets for PC are lacking. The roles of circular RNAs (circRNAs) in cancers have been explored in various studies, however more work is ...
Hao Yuan, Chuang Chen, Haonan Li, Gexi Qu, Luyao Chen, Yaxing Liu, Yufeng Zhang, Qiang Zhao, C. Lian, Aifang Ji, Xuedong Hou, Xinjian Liu, K. Jiang, Yi Zhu, Yuan He   +14 more
semanticscholar   +1 more source

Leucine Supplementation Improves Diastolic Function in HFpEF by HDAC4 Inhibition

Cells, 2023
Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome associated with a high morbidity and mortality rate. Leucine supplementation has been demonstrated to attenuate cardiac dysfunction in animal models of cachexia and heart ...
P. Alves, Antje Schauer, A. Augstein, Anita Männel, P. Barthel, Dirk Joachim, Janet Friedrich, Maria-Elisa Prieto, A. Moriscot, Axel Linke, V. Adams   +10 more
semanticscholar   +1 more source

The possible prognostic role of histone deacetylase and transforming growth factor β/Smad signaling in high grade gliomas treated by radio-chemotherapy: a preliminary immunohistochemical study [PDF]

, 2017
Glioblastoma (GBM) is the most common and aggressive tumor of the central nervous system. Unfortunately, patients affected by this disease have a very poor prognosis, due to high level of invasiveness and resistance to standard therapies.
Cicchinelli, Sara, Di Cesare, Ernesto, Festuccia, Claudio, Gaudio, Eugenio, Gravina, Giovanni L., Marampon, Francesco, Pompili, Simona, Sferra, Roberta, Ventura, Luca, Vetuschi, Antonella   +9 more
core   +2 more sources

Neuronal activity‐dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5 [PDF]

Journal of Neurochemistry, 2003
AbstractThe class II histone deacetylases, HDAC4 and HDAC5, directly bind to and repress myogenic transcription factors of the myocyte enhancer factor‐2 (MEF‐2) family thereby inhibiting skeletal myogenesis. During muscle differentiation, repression of gene transcription by MEF‐2/HDAC complexes is relieved due to calcium/calmodulin‐dependent (CaM ...
Chawla, Sangeeta, Vanhoutte, Peter, Arnold, Fiona, Huang, Christopher L.-H., Bading, Hilmar   +4 more
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

HDAC4 influences the DNA damage response and counteracts senescence by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and homology-directed repair

Nucleic Acids Research
Access to DNA is the first level of control in regulating gene transcription, a control that is also critical for maintaining DNA integrity. Cellular senescence is characterized by profound transcriptional rearrangements and accumulation of DNA lesions ...
Eros Di Giorgio, Emiliano Dalla, Vanessa Tolotto, Francesca D'Este, Harikrishnareddy Paluvai, Liliana Ranzino, Claudio Brancolini   +6 more
semanticscholar   +1 more source

Mesenchymal Stem Cell–Originated Exosomal Circular RNA circFBXW7 Attenuates Cell Proliferation, Migration and Inflammation of Fibroblast-Like Synoviocytes by Targeting miR-216a-3p/HDAC4 in Rheumatoid Arthritis

Journal of Inflammation Research, 2021
Background Rheumatoid arthritis (RA) is a chronic autoimmune disease of articular joint damage and elevated synovial hyperplasia. Abnormal proliferation, invasion inflammatory response of rheumatoid fibroblast-like synoviocytes (RA-FLS) play a critical ...
Li Chang, L. Kan
semanticscholar   +1 more source

Investigating the role of histone deacetylase HDAC4 in long-term memory formation : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Genetics at Massey University, Manawatu, New Zealand [PDF]

, 2016
Listed in 2017 Dean's List of Exceptional ThesesEpigenetic mechanisms are emerging as master regulators of cognitive abilities such as learning and memory.
Schwartz, Silvia
core